Alkyne-Val-Cit-PAB-PNP

Catalog No.: A43448
ADC Linker
Alkyne-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates stable attachment of cytotoxic agents to antibodies while enabling release in the target tissues or cells via specific enzymatic cleavage. Its properties make it suitable for research applications focused on enhancing the efficacy and selectivity of ADCs in cancer therapy and related studies.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAlkyne-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates stable attachment of cytotoxic agents to antibodies while enabling release in the target tissues or cells via specific enzymatic cleavage. Its properties make it suitable for research applications focused on enhancing the efficacy and selectivity of ADCs in cancer therapy and related studies.
Product Information
Catalog NumA43448
FormulaC31H38N6O9
Molecular Weight638.67
CAS Number2748039-77-0
SMILESO=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC#C)=O)=O)=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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