Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
TCO-PEG3-alcohol is a PEG-based linker specifically designed for PROTAC synthesis, functioning primarily through the inverse electron demand Diels-Alder (iEDDA) reaction. This compound features a TCO moiety that enables efficient coupling with tetrazine-conjugated molecules, facilitating the development of targeted protein degradation strategies. Its use in research applications enhances the exploration of protein function and regulation in various biological pathways. -
PROTAC Linkers
DBCO-PEG4-triethoxysilane is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. Its DBCO group facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. This compound is instrumental in the development of targeted protein degradation strategies, enhancing research in cancer therapy and other therapeutic areas. -
PROTAC Linker
TCO4-PEG3-Maleimide is a PROTAC linker designed for targeted protein degradation applications. It features TCO and Maleimide functional groups, enabling precise "click" reactions with tetrazine and thiol compounds, or "mercapto-acrylamide" reactions. This compound facilitates the development of innovative therapeutic modalities by promoting effective protein-interaction dynamics in chemical biology research. -
PROTAC Linker
Methylamino-PEG3-azide serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. In addition, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a valuable tool for chemical biology applications, particularly in targeted protein degradation studies. -
PROTAC Linkers
Methyltetrazine-amido-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases. Its application in PROTAC development enables enhanced therapeutic strategies in the field of targeted protein degradation for various diseases, including cancer. -
PROTAC Linkers
m-PEG4-NH-DBCO is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a dibenzocyclooctyne (DBCO) moiety, enabling effective strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its properties facilitate the development of targeted protein degradation strategies in chemical biology research, positioning m-PEG4-NH-DBCO as a valuable tool for advancing PROTAC technology. -
PROTAC Linker
Aldehyde-benzyl-PEG5-alkyne serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its use in click chemistry reactions, specifically undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. Its utility in synthesizing novel PROTACs makes it valuable for biochemical research applications focused on protein modulation and degradation pathways. -
PROTAC Linker
endo-BCN-PEG3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring a BCN group, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating the formation of complex bioconjugates. Its application in chemical biology makes it a valuable tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
endo-BCN-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique chemoselectivity enhances the development of targeted protein degradation applications in various biological research contexts. -
PROTAC Linkers
Methyltetrazine-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting targeted protein degradation. Its ability to enhance solubility and bioavailability makes it a valuable tool in chemical biology and drug discovery applications focused on protein modulation. -
PROTAC Linkers
APN-C3-PEG4-azide is a PEG-based PROTAC linker featuring an azide functional group, designed for the synthesis of PROTACs. It facilitates the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatile linker is essential for drug development studies involving targeted protein degradation and can enhance the efficiency of modular PROTAC assembly. -
PROTAC Linker
Lipoamido-PEG4-azide is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds, making it a versatile tool in chemical research for targeted protein degradation studies. -
PROTAC linker
Aminooxy-PEG1-azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds, enhancing its versatility in chemical biology applications. -
PROTAC linker
Aminooxy-PEG4-azide is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. With its azide functional group, it effectively participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as DBCO or BCN derivatives. This reagent is essential for enhancing the specificity and efficacy of targeted protein degradation approaches in chemical biology research. -
PROTAC Linker
Methyltetrazine-Sulfo-NHS ester sodium is a recognized PROTAC linker designed for the synthesis of degradation-targeting chimeras. This compound facilitates the conjugation of ligands to proteins of interest, enabling targeted protein degradation studies. Its application spans various areas of research, including drug development and molecular biology, where precise modulation of protein activity is required. -
PROTAC Linkers
Methyltetrazine-PEG8-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the formation of targeted protein degradation complexes by linking the E3 ligase to the protein of interest. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
DBCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for proteolysis-targeting chimeras (PROTACs). This compound effectively facilitates the development of PROTACs by allowing for the conjugation of ligands, enhancing target specificity and degradation efficiency. It is ideal for research applications focusing on targeted protein degradation and the modulation of protein levels in cellular assays. -
PROTAC Linkers
Azido-PEG7-azide is a PEG-based linker designed for the synthesis of PROTACs, functioning through click chemistry. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups. Its versatile reactivity makes it a valuable tool for researchers in chemical biology and drug development. -
PROTAC Linkers
DBCO-C-PEG1 is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent enables precise conjugation and enhances the development of targeted protein degradation studies, contributing to advancements in therapeutic applications and cellular biology research. -
PROTAC linker
NH-bis(C2-PEG1-azide) is a versatile PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for developing targeted protein degradation strategies and is widely applicable in chemical biology and drug discovery research. -
PROTAC Linker
Azido-PEG9-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-bearing compounds. This reagent is instrumental in the development of targeted protein degradation strategies, promoting innovative research in drug discovery and protein regulation. -
PROTAC Linkers
Benzyl-PEG7-azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. This compound plays a crucial role in drug discovery and development by enabling the selective degradation of target proteins. -
PROTAC Linkers
(R)-TCO-OH is a click chemistry reagent designed for use as a linker in PROTAC (proteolysis-targeting chimeras) synthesis. This compound features a trans-cyclooctene (TCO) moiety, which allows it to undergo an inverse electron-demand Diels-Alder (iEDDA) reaction with tetrazine-containing partners, facilitating selective protein degradation. Its application is critical in the development of targeted protein degradation strategies for various biological and therapeutic research areas. -
PROTAC Linker
Azide-PEG3-L-alanine-Fmoc is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its azide functionality. This compound is capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. Its unique properties make it a valuable tool for researchers working on targeted protein degradation and related applications in chemical biology. -
PROTAC Linker
Azido-PEG4-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily as a tool for targeted protein degradation. This compound features an azide group that facilitates click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it suitable for various bioconjugation applications in chemical biology and drug discovery research. -
PROTAC Linkers
TCO-PEG8-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). It facilitates the formation of bifunctional molecules by covalently linking target proteins to E3 ligases, enabling targeted protein degradation. This reagent is essential for researchers exploring innovative therapeutic strategies in cancer, neurodegenerative diseases, and other pathologies through targeted modulation of protein levels. -
PROTAC Linker
DBCO-C2-SulfoNHS ester serves as a key PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound incorporates a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing partners. It plays a crucial role in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Methyltetrazine-propylamine is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This linker features an alkyl chain structure, enhancing the stability and functionality of the resulting conjugates. It is ideal for researchers focusing on targeted protein degradation and the development of innovative therapeutic modalities for various diseases. -
PROTAC Linker
DBCO-NH-Boc is a PROTAC linker featuring a dibenzocyclooctyne (DBCO) moiety that enables efficient synthesis of PROTACs through click chemistry. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, providing a versatile approach for targeted protein degradation research. Its unique structure enhances connectivity and stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linkers
Trityl-PEG10-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Trityl-PEG10-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in PROTAC development. -
PROTAC Linker
Phthalamide-PEG3-azide is a PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Its utility in these chemical reactions makes it a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
AZD-CO-C2-Ph-amido-Ph-azide is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for facilitating targeted protein degradation and advancing research in therapeutic development. -
ADC/PROTAC Linker
Propargyl-PEG5-azide is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Propargyl-PEG5-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile and effective tool for chemical biologists developing targeted therapeutics. -
PROTAC Linker
BCN-PEG4-acid is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a bicyclononyne (BCN) moiety, this compound is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use facilitates the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of drug discovery research. -
PROTAC Linkers
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Its triethoxysilane group facilitates conjugation to various surfaces or substrates, enhancing the development of targeted protein degradation strategies. This compound serves as a crucial tool for researchers investigating targeted therapies and protein modulation. -
PROTAC Linkers
TCO-PEG3-TCO is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs while effectively linking E3 ligases to target proteins, thereby promoting targeted protein degradation. Its applications are vital in research focused on elucidating protein functions and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC linker
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG2-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzocyclooctyne (DBCO) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-amine facilitates the development of PROTACs for targeted protein degradation applications, making it valuable in chemical biology and therapeutic research. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG3)-Cy5 serves as a PEG-based linker for PROTAC technology, facilitating the synthesis of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for researchers in the field of chemical biology and drug development. -
PROTAC Linkers
PC-PEG11-Azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating targeted protein degradation. It features an Azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing compounds. Additionally, PC-PEG11-Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. This versatility makes it a valuable tool for chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG2-PFP ester serves as a PEG-based linker in the synthesis of PROTACs, functioning primarily through its BCN group. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, thereby enabling precise protein degradation applications. Its utility extends to various research areas, including targeted protein modulation and therapeutic development strategies. -
PROTAC Linker
Boc-NH-PEG7-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by leveraging its azide group. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-functionalized compounds and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This linker is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating efficient conjugation in chemical biology research applications. -
PROTAC Linkers
Mal-C2-cyclohexylcarboxyl-hydrazide TFA is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyl chain structure that facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of specific proteins within biological systems. It is a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. -
PROTAC Linker
Folate-PEG3-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Folate-PEG3-alkyne is essential for developing targeted therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
TCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an effective spacer, facilitating the coupling of E3 ligase recruiters and target proteins, thereby enhancing the degradation of specific proteins in cellular assays. Its application in PROTAC development supports investigations into targeted protein degradation and therapeutic strategies in various diseases. -
PROTAC Linkers
Benzyl-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups. The versatility and efficiency of Benzyl-PEG5-azide make it a valuable tool in the development of targeted protein degradation strategies and related chemical biology applications. -
PROTAC Linkers
N-PEG3-N'-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this linker can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. Its application in PROTAC technology supports studies targeting protein degradation pathways for therapeutic discovery. -
PROTAC Linker
Fluorescein-thiourea-PEG4-azide is a PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This reagent is critical for studies focused on targeted protein degradation and can facilitate the development of innovative therapeutic strategies in chemical biology and pharmacology.
