Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
endo-BCN-PEG3-mal is a PEG-based PROTAC linker designed for efficient synthesis of PROTACs. This compound features a BCN moiety that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation studies. Its versatile application in chemical biology makes it valuable for research involving protein modulation and therapeutic development. -
PROTAC Linkers
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker designed for effective synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is widely utilized in chemical biology research for targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linker
endo-BCN-O-PNB is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
Alkyne-PEG4-maleimide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application as a linker facilitates the creation of bifunctional molecules for targeted protein degradation studies and other advanced research applications in chemical biology. -
PROTAC Linker
DBCO-S-S-PEG3-biotin is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating efficient conjugation. Its biotin component enhances detection and purification of PROTACs, making it a valuable tool for biological research focused on targeted protein degradation. -
PROTAC Linker
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies. -
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation. -
PROTAC Linkers
TCO-OH is an alkyl chain-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the creation of targeted therapies by linking E3 ligases to specific proteins for degradation. Its application is essential in the field of targeted protein degradation research, enabling the exploration of new therapeutic strategies in various diseases. -
PROTAC Linker
Methyltetrazine-acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the efficient conjugation of ligands to E3 ligases, enhancing the targeted degradation of specific proteins. This compound is essential for researchers focusing on protein modulation and degradation in various cellular contexts. -
PROTAC Linker
endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its unique structure. As a click chemistry reagent, it features a BCN moiety capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for advancing targeted protein degradation research and enhancing the efficiency of PROTAC assembly in various biological applications. -
Click Chemical
exo-BCN-L-Lysine is a click chemistry reagent that acts as a versatile linker for the synthesis of PROTAC molecules. Featuring a bicyclo[6.1.0]nonyne (BCN) functional group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This property makes exo-BCN-L-Lysine particularly valuable in the development of targeted protein degraders and other bioconjugation applications in chemical biology research. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-NHS ester) serves as a versatile PROTAC linker, facilitating the assembly of PROTACs for targeted protein degradation. This PEG-based compound features a DBCO moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in chemical biology research and drug development applications. -
PROTAC Linker
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) substrates. It is particularly useful in creating tailored PROTACs for targeted protein degradation studies, facilitating the development of new therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
TCO-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins within cells. Its unique structure promotes solubility and stability, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Tetrazine-Ph-acid is a specialized linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating selective and efficient protein degradation. Its application in the development of PROTACs enables researchers to explore targeted protein modulation and therapeutic interventions in various biological systems. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
Ligand for E3 Ligase
Desamino lenalidomide-alkynes specifically targets cereblon (CRBN), an E3 ubiquitin ligase, facilitating the recruitment of this protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). It is instrumental in studies aimed at modulating protein levels and exploring targeted protein degradation mechanisms. -
Ligands for E3 Ligase
(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-C2-alkyne is a conjugate consisting of an E3 ligase ligand derived from cereblon (CRBN) and a C2 alkyne linker. This reagent is designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs), facilitating targeted protein degradation pathways. Its application enables the modulation of specific protein targets, making it a valuable tool in chemical biology research. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate featuring a terminal alkyne functional group. This compound facilitates the conjugation to target proteins, supporting the development of PROTAC (Proteolysis Targeting Chimeras) for targeted protein degradation studies. Its unique structure enables enhanced interaction with E3 ligases, making it a valuable tool for researchers investigating protein regulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugates
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe-alkyne-C6-OMs is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound effectively facilitates the recruitment of E3 ligases, enabling targeted degradation of specific proteins. Its unique linker structure and ligand properties make it a valuable tool in chemical research focused on protein modification and regulation. Use this reagent to explore novel pathways in targeted protein degradation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-alkyne-C4-NHBoc is an E3 Ligase Ligand-Linker Conjugate designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC JAK1 degrader 1, enabling the selective degradation of the JAK1 protein. Its utility in research includes studying protein turnover and the therapeutic potential of targeted protein degradation in various diseases. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate that facilitates the construction of targeted molecular assemblies. This compound is designed to enhance the efficacy of E3 ligase-mediated ubiquitination processes, making it invaluable for research applications in protein degradation and modulation of cellular pathways. Its utility in synthesizing compounds such as JWZ-5-13 underscores its significance in chemical biology studies involving targeted protein elimination. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation. -
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-alkyne-piperidine is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a CRBN-based ligand that interacts with E3 ligases to facilitate targeted protein degradation. Its application in chemical biology enables researchers to explore novel therapeutic strategies and enhance drug development through the modulation of protein levels in various biological systems. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C2-alkyne serves as an E3 ligase ligand-linker conjugate, featuring an alkyl linker and a terminal alkyne group. This compound is designed for efficient conjugation to target proteins, facilitating the development of PROTAC (Proteolysis Targeting Chimera) research. Thalidomide-NH-C2-alkyne is instrumental in studies aimed at exploring targeted protein degradation pathways, contributing to advancements in therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a polyethylene glycol (PEG) linker. This compound is designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular contexts. Its use is essential in research applications focusing on targeted protein degradation and the modulation of protein levels for therapeutic purposes. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-alkyne-C-piperazin is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features a CRBN-based ligand that enables the selective recruitment of E3 ligases for the formation of PROTACs. It serves as a valuable tool for research in protein modulation and therapeutic discovery, facilitating the study of protein homeostasis and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-C3-alkyne is an E3 ligase ligand-linker conjugate that incorporates a ceramide-based ligand (CRBN) and a linker moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective protein degradation by harnessing the ubiquitin-proteasome system, making it valuable for studies in targeted therapy and drug development. Its utility in research applications includes investigating protein-protein interactions and exploring new therapeutic strategies for various diseases. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
Pip-alkyne-Ph-COOCH3 is a versatile PROTAC linker designed for the synthesis of PROTAC ARD-266. This compound features an alkyne group, facilitating its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). It plays a critical role in forming stable linkages between target proteins and E3 ligases, supporting research in targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Carboxyrhodamine 110-PEG4-alkyne is a PEG (polyethylene glycol)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the effective conjugation of target proteins to an E3 ligase for selective degradation. This compound is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies. Its properties enable precise modulation of biological activity in various cellular contexts. -
PROTAC Linkers
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker designed for use in the synthesis of targeted protein degraders. It facilitates the development of PROTACs, including ARD-266, which effectively promotes degradation of the androgen receptor in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, exhibiting DC50 values of 0.2-1 nM. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it essential for click chemistry applications in chemical biology research. -
PROTAC Linker
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based linker specifically designed for PROTAC synthesis. This compound features a TCO moiety that facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules, enabling effective targeting and degradation of proteins. It is widely used in chemical biology to create novel therapeutics and to study protein interactions and degradation pathways. -
PROTAC Linker
Cbz-NH-PEG-alkyne is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases, enabling targeted therapeutic applications in cancer and other diseases. Its unique alkyne group allows for efficient conjugation and modification, making it an essential reagent for chemical biology researchers investigating targeted protein degradation. -
PROTAC Linker
Alkyne-PEG4-I is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality facilitates the formation of stable covalent bonds, enabling efficient engagement of target proteins for degradation. This linker is integral for researchers investigating targeted protein degradation pathways and developing novel therapeutic agents. -
PROTAC Linker
Azide-PEG12-Tos is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Azide-PEG12-Tos is valuable for researchers working on targeted protein degradation and other bioconjugation applications. -
PROTAC Linker
Ts-PEG3-O-C-alkynes-TBS is a linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to the ubiquitin-proteasome system, enabling selective protein degradation. It serves as a pivotal component in PROTAC development, enhancing the efficacy of targeted protein modulation for various research applications, including cancer biology and therapeutic discovery. -
PROTAC Linker
DBCO-PEG5-GGG-NH2 is a versatile PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound efficiently connects target proteins with E3 ligases, enabling the modulation of protein degradation pathways. Its application in synthetic biology allows researchers to explore targeted protein degradation strategies for therapeutic interventions. -
PROTAC Linker
m-PEG5-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of protein ligands to E3 ligases, enhancing the targeted degradation of specific proteins within the cell. m-PEG5-Hydrazide is essential for researchers aiming to develop novel therapeutic strategies through targeted protein modulation and degradation. -
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems. -
PROTAC Linker
1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development. -
PROTAC Linker
TBS-PEG4-O-alkyne is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands to an E3 ubiquitin ligase, allowing for targeted degradation of specific proteins. Its key biological activity lies in enhancing the solubility and bioavailability of PROTACs, making it an essential component in targeted protein degradation research. TBS-PEG4-O-alkyne is widely utilized in pharmacological studies and drug discovery applications. -
PROTAC Linker
(S,R,S)-Ahpc-PEG6-azide is a click chemistry PROTAC linker that integrates an E3 ligase ligand and a PEG6 arm, facilitating the advancement of PROTAC research and discovery. The hydrophilic PEG spacer enhances solubility in aqueous environments, making it suitable for various biological applications. The presence of the azide functionality allows for efficient click chemistry reactions with alkyne, DBCO, or BCN molecules, thereby enabling versatile conjugation strategies in drug development. -
PROTAC linker
endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by enabling targeted protein degradation. This compound features a bicyclononyne (BCN) group, which allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its applications extend to the development of advanced therapeutic modalities in chemical biology and drug discovery. -
PROTAC Linker
m-PEG6-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands to target proteins by providing a flexible and hydrophilic spacer. Its unique structure enhances the solubility and stability of PROTACs, making it an essential tool for studies focused on targeted protein degradation and drug discovery applications. -
PROTAC Linker
H2N-PEG4-Hydrazide is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing target degradation through the ubiquitin-proteasome system. H2N-PEG4-Hydrazide is essential for researchers exploring targeted protein degradation approaches in drug discovery and development.
