Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
DBCO-PEG2-acid is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring a DBCO group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for the development of targeted protein degradation strategies in chemical biology research. Its ability to form stable linkages enhances the design and application of bifunctional molecules for therapeutic development. -
PROTAC Linker
PEG2-bis(Alkyne) is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins via the ubiquitin-proteasome system. Its unique alkyne functionality enables efficient click chemistry, making it suitable for various research applications in targeted protein degradation studies and drug discovery. -
Ligands for Target Protein for PROTAC
BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) serves as a versatile ligand for target proteins in PROTAC applications. This compound incorporates a sulfonamide linker designed to enhance the solubility of linker-conjugates. It is particularly useful in the synthesis of PROTACs aimed at inducing targeted degradation of proteins with potential antitumor activity. -
Protein degrader
Tri-GalNAc-DBCO is a synthetic ligand featuring three GalNAc units linked to DBCO, designed for use in protein degradation applications. It selectively targets the asialoglycoprotein receptor (ASGPR), facilitating the delivery of conjugated proteins or small molecules to lysosomes via receptor-mediated endocytosis. This targeted approach allows for the effective degradation of substrates, making Tri-GalNAc-DBCO a valuable tool in research focusing on lysosomal-targeted therapeutics and protein modulation strategies. -
PROTAC Linker
DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise bioconjugation. Its application is critical in the development of targeted protein degradation strategies, enhancing the ability to study protein interactions and manipulate cellular processes. -
PROTAC Linkers
Biotin alkyne is a PEG-based linker designed for the synthesis of PROTACs, targeting the ubiquitin-proteasome system. As a click chemistry reagent, it features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. This functionality facilitates the efficient assembly of bifunctional degraders, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Biotin-PEG4-alkyne is a biotin-functionalized linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This PEG-based compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient conjugation with azide-containing molecules. Its application is vital in developing PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
TCO-PEG4-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs. Its primary mechanism involves click chemistry, specifically the inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG4-NHS ester facilitates targeted protein degradation, making it a valuable tool for research applications in pharmacology and molecular biology, particularly in the development of novel therapeutics. -
PROTAC Linker
Methyltetrazine-Ph-NHS ester is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a tetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) moieties. Its key biological activity lies in enabling targeted protein degradation, providing a valuable tool for researchers exploring protein function and dynamics in cellular systems. Methyltetrazine-Ph-NHS ester is suitable for applications in chemical biology and drug discovery research. -
PROTAC Linker
DBCO-Biotin is a PROTAC linker featuring an alkyl chain structure that facilitates the synthesis of PROTACs. As a click chemistry reagent, it contains a DBCO moiety that efficiently undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes DBCO-Biotin a valuable tool in targeted protein degradation research, allowing for the precise construction of bifunctional compounds necessary for therapeutic development. -
Click Chemistry Reagent
Halo-DBCO is a click chemistry reagent featuring dibenzocyclooctyne (DBCO) that serves as a highly efficient ligand for HaloTag proteins. This compound facilitates the formation of covalent bonds between HaloTag and DBCO, enabling precise labeling and functionalization of biomolecules. Halo-DBCO is valuable in applications such as protein visualization, targeted drug delivery, and biosensing, making it a critical tool in chemical biology and bioconjugation studies. -
PROTAC Linker
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances target specificity and cellular degradation efficiency by linking E3 ligases to target proteins. Its application in PROTAC development enables the study of targeted protein degradation mechanisms, providing valuable insights in drug discovery and therapeutic interventions. -
PROTAC Linker
DBCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-containing molecules, enabling precise conjugation. This reagent is essential for researchers developing PROTACs aimed at targeted protein degradation, thereby enhancing insights in various biological processes and therapeutic applications. -
PROTAC Linker
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
endo-BCN-PEG3-mal is a PEG-based PROTAC linker designed for efficient synthesis of PROTACs. This compound features a BCN moiety that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation studies. Its versatile application in chemical biology makes it valuable for research involving protein modulation and therapeutic development. -
PROTAC Linkers
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker designed for effective synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is widely utilized in chemical biology research for targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linker
endo-BCN-O-PNB is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
Alkyne-PEG4-maleimide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application as a linker facilitates the creation of bifunctional molecules for targeted protein degradation studies and other advanced research applications in chemical biology. -
PROTAC Linker
DBCO-S-S-PEG3-biotin is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating efficient conjugation. Its biotin component enhances detection and purification of PROTACs, making it a valuable tool for biological research focused on targeted protein degradation. -
PROTAC Linker
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies. -
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation. -
PROTAC Linkers
TCO-OH is an alkyl chain-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the creation of targeted therapies by linking E3 ligases to specific proteins for degradation. Its application is essential in the field of targeted protein degradation research, enabling the exploration of new therapeutic strategies in various diseases. -
PROTAC Linker
Methyltetrazine-acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the efficient conjugation of ligands to E3 ligases, enhancing the targeted degradation of specific proteins. This compound is essential for researchers focusing on protein modulation and degradation in various cellular contexts. -
PROTAC Linker
endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its unique structure. As a click chemistry reagent, it features a BCN moiety capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for advancing targeted protein degradation research and enhancing the efficiency of PROTAC assembly in various biological applications. -
Click Chemical
exo-BCN-L-Lysine is a click chemistry reagent that acts as a versatile linker for the synthesis of PROTAC molecules. Featuring a bicyclo[6.1.0]nonyne (BCN) functional group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This property makes exo-BCN-L-Lysine particularly valuable in the development of targeted protein degraders and other bioconjugation applications in chemical biology research. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-NHS ester) serves as a versatile PROTAC linker, facilitating the assembly of PROTACs for targeted protein degradation. This PEG-based compound features a DBCO moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in chemical biology research and drug development applications. -
PROTAC Linker
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) substrates. It is particularly useful in creating tailored PROTACs for targeted protein degradation studies, facilitating the development of new therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
t-Boc-Aminooxy-PEG5-azide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This linker is valuable for researchers developing targeted protein degradation strategies in chemical biology and therapeutic applications. -
PROTAC Linker
Bromo-PEG7-azide is a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis, facilitating targeted protein degradation. This compound features an azide functional group, enabling its use in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for researchers in chemical biology and drug development applications. -
PROTAC Linkers
DBCO-NHCO-PEG2-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO (dibenzylcyclooctyne) group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances the attachment of PROTACs to target proteins, facilitating studies on targeted protein degradation and cellular dynamics. DBCO-NHCO-PEG2-Biotin is essential for research applications involving targeted therapeutic strategies and the exploration of protein interactions. -
PROTAC Linker
Azide-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring an azide group, it is a versatile click chemistry reagent that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, Azide-PEG2-MS can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules, facilitating the development of innovative protein-targeting therapies. This linker is ideal for researchers investigating protein degradation and its therapeutic potential. -
PROTAC Linkers
DBCO-PEG9-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound enables precise and efficient conjugation strategies, making it valuable for applications in targeted protein degradation research. -
PROTAC Linkers
TCO-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation. Its versatile structure makes it a valuable tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
DBCO-PEG6-amine is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This versatile reagent facilitates the construction of bifunctional molecules for targeted protein degradation studies, enhancing research in cellular regulation and therapeutic development. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound features an azide moiety that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzoazacyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the development of versatile bioconjugates in chemical biology research. -
PROTAC Linker
Methyltetrazine-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is suitable for applications in drug discovery and development, enabling researchers to investigate protein function and therapeutic potential in various biological contexts. -
PROTAC Linkers
DBCO-PEG1-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, this compound facilitates efficient click chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. DBCO-PEG1-acid is integral for developing targeted degradation strategies in protein research, enabling precise modulation of protein levels for various biological applications. -
PROTAC Linkers
HyNic-PEG2-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its efficient click chemistry properties enable precise conjugation, making it valuable for studies in targeted protein degradation and therapeutic development. Applications of HyNic-PEG2-DBCO include the creation of custom PROTACs for probing biological pathways and evaluating protein interactions. -
PROTAC Linkers
Methyltetrazine-PEG8-NHS ester is a PEG-based linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound effectively connects a target protein and an E3 ligase for targeted degradation, enhancing the specific elimination of proteins in cellular systems. Its utility in PROTAC synthesis makes it an essential reagent for researchers exploring novel therapeutic strategies in cancer and other diseases. -
PROTAC Linkers
TCO-PEG4-biotin is a PEG-based PROTAC linker designed to facilitate the construction of PROTACs. This compound enhances the solubility and stability of the resulting bifunctional molecules, enabling targeted protein degradation. Its incorporation into PROTACs allows for selective modulation of target proteins, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
TCO-PEG2-Sulfo-NHS ester is a PEGylated PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation of targeting ligands to E3 ligases, enhancing cellular degradation of specific proteins. Its utility in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linker
endo-BCN-PEG3-acid is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing target degradation by connecting ligands to E3 ligases. Its utility in protein modulation research positions it as a valuable tool for studies focusing on targeted protein degradation strategies in various diseases. -
PROTAC Linkers
TCO-PEG8-TFP ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing protein degradation processes. Its structural properties allow for improved solubility and cellular uptake, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTAC Linker
Azido-PEG11-azide is a PEG-based PROTAC linker designed to facilitate the synthesis of protein degradation therapeutics. Featuring azide functional groups, it is a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, enabling effective modular assembly in drug development and chemical biology applications. -
PROTAC Linkers
N-(Acid-PEG2)-N-bis(PEG3-azide) serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linkers
DBCO-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves the DBCO group, which enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for facilitating site-specific conjugation in PROTAC development, contributing to targeted protein degradation in cellular research and therapeutic applications. -
PROTAC Linker
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This reagent features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation. Its unique properties make it valuable for applications in chemical biology and drug discovery. -
PROTAC Linker
Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is a versatile PROTAC linker designed for targeted protein degradation applications. This hydrazide compound facilitates the formation of bifunctional molecules, promoting the effective assembly of E3 ligases and target proteins. It serves as a key building block in the development of novel PROTACs for studying protein dynamics and therapeutic interventions in various diseases. -
PROTAC Linkers
Bromoacetyl-PEG3-DBCO is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzylcyclooctyne (DBCO) group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It plays a critical role in the development of targeted protein degradation strategies, facilitating the formation of highly functionalized PROTACs for various biological research applications. -
PROTAC Linker
Benzyl-PEG2-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds possessing DBCO or BCN groups. This reagent is instrumental in the development of targeted protein degradation strategies in chemical biology research.
