DBCO-NHCO-PEG2-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO (dibenzocyclooctyne) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted degradation of specific proteins, enhancing research in pharmacology and therapeutic discovery.
DBCO-NHCO-PEG2-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO (dibenzocyclooctyne) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted degradation of specific proteins, enhancing research in pharmacology and therapeutic discovery.
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