DSPE-PEG4-DBCO is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. As a versatile click chemistry reagent, DSPE-PEG4-DBCO facilitates the construction of bifunctional probes for targeted protein degradation studies and other applications in chemical biology.
DSPE-PEG4-DBCO is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. As a versatile click chemistry reagent, DSPE-PEG4-DBCO facilitates the construction of bifunctional probes for targeted protein degradation studies and other applications in chemical biology.
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