Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
IKP-104 is a potent tubulin inhibitor with an IC50 of 1.31 μM, targeting microtubule polymerization to arrest cells in mitosis during the M phase. This compound induces cytoskeletal microtubule depolymerization, effectively inhibiting the growth of various mouse and human tumor cell lines. Additionally, IKP-104 demonstrates notable anti-tumor effects in mouse ascites tumors and lung cancer models, making it a valuable tool for research in leukemia, lung cancer, and melanoma. -
Antitumor Agent
Antitumor agent-67 functions primarily as an antitumor agent with a specific mechanism of selectively targeting cancer cells. It demonstrates significant cytotoxicity towards tumor cells while exhibiting minimal effects on normal cells. The compound is activated by NQO1, which facilitates the release of podophyllotoxin, leading to effective tumor cell death. In preclinical studies, antitumor agent-67 has shown notable efficacy in inhibiting tumor growth in HepG2 xenograft models, with an advantageous toxicity profile. -
Anticancer Agents
Tubulin inhibitor 48 is a potent anticancer agent that targets tubulin dynamics. It exhibits IC50 values of 0.1 μM and 0.07 μM against LN-229 and Capan-1 cell lines, respectively, demonstrating effective growth inhibition. This compound can be utilized in research looking to explore tubulin modulation in cancer therapy. -
Antimitotic Agent
DAT1 is a potent antimitotic agent that targets spindle microtubules to disrupt chromosome organization. This compound exhibits significant anticancer effects, particularly in HeLa cells, by blocking spindle function. DAT1 is valuable for research applications focused on cancer cell dynamics and spindle assembly. -
Microtubule Inhibitor
(Rac)-Deox B 7,4 is a homoisoflavanoid compound that acts as a microtubule inhibitor by binding near the colchicine site, disrupting microtubule polymerization and leading to reversible G2 phase arrest. This compound exhibits potent nanomolar anti-leukemic activity, making it a valuable tool for research into cancer therapeutics and cellular dynamics. Its ability to modulate cytoskeletal functions holds promise for studies related to cell cycle regulation and tumor progression. -
Anticancer Agent
OXS007417 is an anticancer agent that promotes the differentiation of acute myeloid leukemia cells, exhibiting an effective concentration (EC50) of 48 nM in vitro. Its significant antitumor effects have been demonstrated in vivo, making it a valuable tool for research aimed at understanding and developing treatments for leukemia. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-15 is a selective inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound exhibits significant potential in cancer research by hindering cell division and inducing apoptosis in tumor cells. It can be utilized to study the mechanisms of cancer progression and the role of microtubules in cellular processes. -
Colchicine Metabolite
Colchiceine is a metabolite of the anti-gout medication colchicine, functioning primarily as a tubulin inhibitor and microtubule-disrupting agent. This compound exhibits potential protective effects against liver injury and fibrosis in experimental models, contributing to understanding liver pathologies. Colchiceine serves as a valuable research tool for studying microtubule dynamics and the therapeutic mechanisms of colchicine in inflammatory and fibrotic conditions. -
ER Degrader
ER Degrader 7 is a selective degrader of estrogen receptors ERα and ERβ, promoting their degradation to inhibit estrogen signaling. This compound demonstrates significant cytotoxicity in various breast cancer cell lines, with IC50 values of 0.06 µM in MCF-7, 2.56 µM in T47D, and varying values in other cell types. Additionally, ER Degrader 7 has been shown to impede tubulin polymerization, contributing to its effectiveness in inhibiting breast cancer tumor growth. This makes it a valuable tool for research into targeted therapies for hormone-driven malignancies. -
PPL Agonist
PPL agonist-1 is a selective agonist targeting Periplakin (PPL), known to enhance cyclic adenosine monophosphate (cAMP) levels. This modulation of PPL significantly increases MITF expression, leading to augmented melanin synthesis. Additionally, PPL agonist-1 influences tryptophan metabolism to further stimulate melanin production. Its efficacy positions PPL agonist-1 as a promising candidate for research aimed at investigating potential treatments for vitiligo. -
Tubulin Destabilizer
7-Benzoyloxindole is a tubulin destabilizer that disrupts microtubulin structure, leading to inhibited tumor cell growth. This compound is particularly relevant for research applications in gastric cancer and lung cancer, making it a valuable tool for studying tumor dynamics and potential therapeutic strategies. -
Tubulin Inhibitor
SPA107 is a tubulin inhibitor that prevents tubulin polymerization, demonstrating potent antimitotic activity with an IC50 of 0.5 nM. In addition, SPA107 exhibits significant cytotoxic effects in p53 mutated MCF-7 cells, with an IC50 of 0.5 nM. This compound is valuable for research in cancer biology, particularly in studies focused on mitotic disruption and the mechanisms underlying drug resistance. -
Tubulin Inhibitor
HD-800 is a potent tubulin inhibitor, exhibiting an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. This compound is valuable for generating the radioactive tracer [11C]HD-800, which is capable of penetrating the blood-brain barrier. [11C]HD-800 serves as a useful tool for positron emission tomography (PET) applications in studying various neurological disorders. -
Tubulin Inhibitor
isoCA-4 is a tubulin polymerization inhibitor derived from Combretastatin A4. It exhibits significant anti-proliferative activity, making it a valuable tool for studying cancer cell growth and metastasis. This compound can be utilized in research applications focused on tumor biology and the development of novel cancer therapeutics. Its mechanism of action provides insights into disrupting microtubule dynamics in cellular systems. -
Isoflavanone Compound
Violanone is an isoflavanone compound that effectively inhibits tubulin polymerization. This activity is crucial for disrupting microtubule dynamics, making it significant for cancer research. Additionally, Violanone demonstrates larvicidal efficacy against Aedes aegypti, highlighting its potential applications in vector control studies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-27 is a selective inhibitor of tubulin polymerization, disrupting microtubule dynamics and thereby arresting the cell cycle at the G2/M phase. This compound induces apoptosis in cancer cells, making it a valuable tool for studying cell cycle regulation and apoptosis mechanisms in various research applications. It is suitable for investigations into cancer biology and therapeutic strategies targeting microtubule assembly. -
Microtubule Assembly Inducer
2'-Deoxy-PTX is a derivative of Paclitaxel that functions as a microtubule assembly inducer. It binds efficiently to GMPcPP-stabilized microtubules, exhibiting a binding affinity with a Kaapp of 0.50 × 10^6 M^-1. By promoting the assembly of tubulin into stable microtubules, 2'-Deoxy-PTX serves as a valuable reagent in cancer research, particularly in studies focused on prostate cancer. -
Anticancer Agent
Acodazole hydrochloride is an anticancer agent that functions by inhibiting microtubule polymerization. This mechanism disrupts the normal mitotic process, leading to cell cycle arrest and ultimately apoptosis in cancer cells. Acodazole hydrochloride is primarily used in cancer research to explore therapeutic strategies targeting microtubule dynamics and to evaluate its efficacy in various malignancies. -
Ansamitocin Derivative
20-O-Demethyl-AP3 is an ansamitocin derivative that functions as a microtubule inhibitor. It exhibits potent antitumor activity by disrupting microtubule dynamics, thus interfering with cell division and proliferation. This compound is primarily utilized in cancer research to study the mechanisms of action of microtubule-targeting agents and their potential therapeutic effects. -
Microtubule Inhibitor
Tubulozole is a synthetic microtubule inhibitor that exerts its effects by disrupting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. It is primarily utilized in research focused on cancer biology, particularly in the study of tumor growth and metastasis. Tubulozole's ability to inhibit microtubule polymerization makes it a valuable tool in the investigation of novel therapeutic strategies for cancer treatment. -
Antitumor Agent
Ortataxel is a novel antitumor agent that functions as a microtubule stabilizer, effectively disrupting cell division. It demonstrates significant cytotoxic activity against various drug-sensitive and resistant cancer cell lines, making it a valuable tool for cancer research. Its potential applications include assessing drug resistance mechanisms and exploring combination therapies in preclinical studies. -
Microtubule Polymerization Inhibitor
Bruceoside D is a microtubule polymerization inhibitor derived from the quassinoid glucoside found in Brucea javanica. This compound exhibits cytotoxic effects against several cancer cell lines, including leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3). Bruceoside D is a valuable tool for researchers investigating potential cancer therapeutics and the mechanisms underlying tumor cell growth and proliferation. -
Microtubule Inhibitor
ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma. -
Microtubule/Tubulin Inhibitor
BP-M345 is a potent microtubule/tubulin inhibitor that effectively targets cancer cells while demonstrating low toxicity to non-tumor cells. This compound exhibits significant antiproliferative activity, with a GI50 value ranging from 0.17 to 0.45 μM, making it an important tool for cancer research and therapeutic studies. Its ability to selectively inhibit cancer cell proliferation positions BP-M345 as a valuable reagent for exploring cancer biology and potential treatment options. -
Tubulin Inhibitor
Tubulin inhibitor 18 is a potent inhibitor of tubulin, primarily functioning through disruption of microtubule polymerization. As a chalcone derivative, it exhibits significant anti-proliferative activity in various cancer cell lines. This compound is valuable for research applications targeting cancer diseases, enabling further investigation into tubulin dynamics and therapeutics. -
Inhibitors of Tubulin Polymerization
KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications. -
Paclitaxel Derivative
Paclitaxel succinate sulfo-NHS ester is a derivative of Paclitaxel that serves as an active compound targeting cellular microtubules. This reagent exhibits potent anti-cancer activity and is primarily used in oncological research to study the effects of Paclitaxel modifications on drug delivery and efficacy. Its application may enhance the understanding of cancer therapies and facilitate the development of novel therapeutic strategies. -
Tubulin Inhibitor
Tubulin polymerization-IN-12 is a potent tubulin polymerization inhibitor with an IC50 of 0.75 μM. By disrupting normal tubulin assembly, it effectively arrests the cell cycle at the G2/M phase, leading to significant cytotoxic effects against cancer cells. This compound is valuable for research in cancer biology and the mechanisms of cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-16 is a potent tubulin polymerization inhibitor designed to disrupt microtubule dynamics. This compound demonstrates significant anti-cancer activity with IC50 values ranging from 0.084 to 0.221 μM, effectively inducing cell cycle arrest at the G2/M phase in SGC-7901 cells. Its ability to inhibit tubulin polymerization makes it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Polymerisation Inhibitor
N-Acetylcolchinol phosphate is a potent inhibitor of tubulin polymerization. It binds to the tubulin cytoskeleton in the endothelial cells of tumor blood vessels, disrupting microtubule dynamics. This compound is valuable in anti-cancer research, providing insights into tumor vasculature and potential therapeutic strategies. Its application facilitates the study of tumor progression and vascularization in various cancer models. -
Centrosomal Clustering Inhibitor
GF 15 is a centrosomal clustering inhibitor that acts by inducing multipolar spindles with an EC50 value of 900 nM. As a derivative of griseofulvin, it effectively inhibits tubulin polymerization at concentrations exceeding 25 μM. GF 15 demonstrates notable antitumor activity, significantly inhibiting tumor growth and improving survival rates in mouse xenograft models of human colon cancer and multiple myeloma. This reagent is valuable for researchers studying cellular mitosis and the mechanisms of cancer progression. -
Anticancer Agent
Anticancer Agent 48 inhibits tubulin polymerization, acting as a broad-spectrum anticancer agent. This compound demonstrates significant antiproliferative activity and exhibits robust antitumor effects in vivo. Anticancer Agent 48 has considerable potential for research applications targeting both solid and hematological tumors. -
Microtubule Destabilizing Agent
Microtubule Destabilizing Agent-1 is a hydroxamic acid-based compound that functions as a microtubule destabilizing agent (MDA). It exhibits significant antitumor activity and demonstrates favorable metabolic stability along with high bioavailability. This compound is suitable for investigations into cancer therapeutics targeting microtubule dynamics. -
Microtubule Inhibitor
IQTub4P is a potent microtubule inhibitor that disrupts microtubule structure and function. It exhibits significant cytotoxicity in HeLa cells with an EC50 value of 170 nM, highlighting its potential for targeting cancer cell proliferation. This compound demonstrates favorable tolerability in vivo, making it a valuable tool for studying microtubule dynamics and exploring therapeutic applications in cancer research. -
Microtubule Inhibitor
Desacetylvinblastine hydrazide is a microtubule inhibitor that disrupts mitotic spindle formation, effectively inhibiting cell division and promoting apoptosis in cancer cells. This compound demonstrates significant antitumor activity specifically against folate receptor (FR)-positive tumors. It is widely utilized in cancer research to investigate mechanisms of drug resistance and therapeutic efficacy in targeted cancer therapies. -
Microtubule Growth Inhibitor
α-Tubulin (residues 440–451) functions as a microtubule growth inhibitor by transiently interacting with the longitudinal polymerization interface of α-tubulin. This interaction effectively regulates the association and dissociation rates of tubulin at the growing ends of microtubules, leading to inhibited microtubule growth. This reagent can be utilized in studies exploring microtubule dynamics, cellular morphology, and potential therapeutic targets for diseases associated with abnormal microtubule formation. -
Tubulin Inhibitor
Tubulin Inhibitor 49 is a potent tubulin polymerization inhibitor with an IC50 value of 48 μM. This compound disrupts the microtubule network, leading to G2 phase cell cycle arrest and demonstrating cytotoxicity with an IC50 of 8.8 μM in HeLa cells. Tubulin Inhibitor 49 serves as a valuable tool for researching cervical cancer and understanding the mechanisms of microtubule dynamics in cancer cell proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-48 is a potent inhibitor of tubulin polymerization, demonstrating the ability to disrupt microtubule networks. This compound exhibits significant anti-proliferative activity in neuroblastoma cancer cell lines, with IC50 values of 79 nM for Chp-134 and 165 nM for Kelly cells. Its mechanism makes it a valuable tool for research in cancer biology and cellular dynamics. -
Neuronal Differentiation Inducer
TCS 2210 is a neuronal differentiation inducer that promotes the differentiation of mesenchymal stem cells (MSCs) into neuronal lineages. This compound enhances the expression of key neuronal markers, including β-III tubulin and neuron-specific enolase (NSE), making it a valuable tool for research in neurogenesis and neural cell development. Its application supports investigations into neurodegenerative diseases and potential regenerative therapies. -
Anticancer Agent
ABJ-879 is an epothilone derivative that functions as an anticancer agent by targeting tubulin. This compound disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. ABJ-879 is utilized in cancer research to investigate its efficacy and mechanism of action in various malignancies. -
Microtubule Polymerization Inhibitor
Acodazole is a microtubule polymerization inhibitor that exhibits potent anticancer activity. By disrupting the assembly of microtubules, Acodazole interferes with mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells. This compound is valuable for research in cancer biology and for exploring novel therapeutic strategies targeting microtubule dynamics. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-36 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 2.8 μM. This compound selectively binds to the colchicine site of tubulin, thereby obstructing colchicine binding and disrupting microtubule formation. Tubulin polymerization-IN-36 is valuable for researching various cancers, including lymphomas, and provides insights into the mechanisms of tumorigenesis and cell division. -
colchicine-binding site inhibitor (CBSI)
Antitumor agent-164 is a colchicine-binding site inhibitor (CBSI) that demonstrates significant potency against taxane-sensitive triple-negative breast cancer (TNBC). This compound serves as a next-generation derivative of VERU-111, enhancing its potential for targeted cancer therapy. Its mechanism of action involves disrupting microtubule dynamics, making it a valuable tool for investigating treatment responses and resistance mechanisms in breast cancer models. -
Microtubule/Tubulin Inhibitor
Denibulin is a microtubule-tubulin inhibitor that reversibly disrupts microtubule assembly, affecting the cytoskeleton of tumor vascular endothelial cells. This novel vascular-disrupting agent exhibits tolerability and shows potential for anti-vascular effects, making it a candidate for further research in cancer therapy applications. Its mechanism offers insights into the modulation of tumor vasculature, supporting its exploration in studies of tumor growth and metastasis. -
Anticancer Agent
CAY10701 is a 7-deazahypoxanthine analogue that exhibits significant anticancer activity. This compound interferes with critical cellular processes, making it a valuable tool for cancer research. Its ability to modulate cell proliferation and survival pathways positions it as an important reagent for investigating therapeutic strategies in oncology. -
Paclitaxel Analogue
BMS 275183 is a potent orally active analogue of Paclitaxel that targets microtubule stabilization. This compound exhibits significant antitumor activity in in vivo models, demonstrating efficacy against Paclitaxel-resistant tumors, including those with tubulin mutations or overexpressing P-glycoprotein. BMS 275183 is valuable for cancer research applications, particularly in studying non-small cell lung cancer (NSCLC) and prostate carcinoma. -
Microtubule Inhibitor
Microtubule Inhibitor 4 is a potent inhibitor of microtubule polymerization, targeting tubulin. This compound exhibits significant cytotoxic effects in various cancer cell lines, with IC50 values of 4.0 nM for NCI-H460, 3.2 nM for BxPC-3, and 2.1 nM for HT-29 cells. It is an essential tool for research in cancer biology and the evaluation of anti-cancer therapeutics. -
Mitotic Regulator
P34cdc2 Kinase Fragment is a crucial mitotic regulator that plays an essential role in the completion of DNA replication during yeast mitosis. This kinase exhibits the capability to phosphorylate mitogen-activated protein 2 (MAP2), thereby regulating microtubule polymerization in Xenopus oocyte meiosis. Its activity is vital for studies on cell cycle regulation and the mechanisms underlying mitotic progression. -
Tubulin Inhibitor
Tubulin Inhibitor 28 is a highly effective tubulin inhibitor, demonstrating an IC50 value of 1.2 µM. This compound exhibits significant anti-proliferative activity in MCF-7 breast cancer cell lines, making it a valuable tool for cancer research and studies focusing on cell division and cytoskeletal dynamics. Its ability to disrupt microtubule formation suggests potential applications in exploring therapeutic strategies for cancer treatment. -
MASTL Inhibitor
MASTL-IN-5 is a potent inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with a Ki of 0.018 nM. This compound selectively targets the kinase activity of MASTL, playing a critical role in regulating cell cycle progression and mitotic functions. MASTL-IN-5 is useful in research applications focused on cancer biology, particularly in studying the effects of MASTL inhibition on cell division and tumor proliferation.
