Catalog No.
Product Name
Application
Product Information
Citations
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Mitotic Arrest Inducer
Centmitor-1 is a potent mitotic arrest inducer that targets microtubule dynamics by modulating microtubule plus-ends. Its application in cell studies reveals significant phenotypes, including chromosome alignment defects, multipolar spindle formation, centrosome fragmentation, and activation of the spindle assembly checkpoint. Centmitor-1 serves as a valuable tool for investigating mitotic processes and exploring therapeutic strategies in cancer research. -
Intermediate Reactant
Monomethyl auristatin E intermediate-13 is a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with demonstrated anticancer activity. MMAE is commonly employed as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted cancer therapy. This intermediate is essential for research applications focused on the development and optimization of ADCs in cancer treatment. -
BNC105 Prodrug
BNC105P is a phosphate prodrug of BNC105 that functions as a vascular disrupting agent (VDA) and an antitumor agent upon conversion to the active form, BNC105. This compound selectively targets tumor vasculature, leading to disruption of blood flow and subsequent tumor cell death. BNC105P is utilized in cancer research to investigate therapeutic strategies aimed at targeting tumor microenvironments and enhancing treatment efficacy. -
Cytochalasin
Cytochalasin J is a cytochalasin derivative that targets microtubule organization. It disrupts mitotic spindle formation and alters kinetochore structure, demonstrating cytotoxic effects in human leukemia K562 cells with an IC50 of 1.5 μM. This compound is valuable for research applications in cancer biology, particularly in the study of cell division and cancer cell dynamics. -
Intermediate Reactant
Monomethyl auristatin E intermediate-12 serves as an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor known for its anticancer properties. This compound plays a crucial role as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted delivery in cancer therapy. Its use in research applications contributes to the development of innovative therapeutic strategies in oncology. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-57 is a potent tubulin polymerization inhibitor affecting microtubule dynamics. This α-naphthoxy-substituted carbendazim derivative induces mitotic arrest, effectively inhibiting proliferation in cancer cells. It demonstrates promising potential for research applications in cancer biology and therapeutic development. -
Antimitotic Agent
Alfalone is an antimitotic agent that inhibits cell division by disrupting microtubule dynamics, leading to cleavage arrest and the formation of tuberculate eggs. This compound is valuable for research applications in cell biology and developmental studies, particularly in understanding the mechanisms of mitotic regulation and the effects on embryonic development. -
Intermediate Reactant
Monomethyl auristatin E intermediate-4 serves as a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor exhibiting significant anticancer activity. MMAE is commonly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted delivery and efficacy in cancer therapy. Researchers use this intermediate for developing ADCs and studying microtubule dynamics in cancer cell biology. -
Microtubule/Tubulin Inhibitor
Tubulin Inhibitor 9 is a microtubule-targeting compound that selectively inhibits tubulin polymerization. Demonstrating potent anticancer activity, this compound achieves an IC50 of 0.9 nM in the MDA-MB 231 breast cancer cell line. It serves as a valuable tool for investigating microtubule dynamics and evaluating potential therapeutic strategies in cancer research. -
Microtubule/Tubulin Inhibitor
Cis-Trismethoxy resveratrol acts as a microtubule/tubulin inhibitor, demonstrating potent anti-mitotic properties. It effectively inhibits tubulin polymerization with an IC50 value of 4 μM. This compound is valuable for research applications focused on cell division, cancer biology, and the study of microtubule dynamics. -
Mitotic Inhibitor
MT-7 is a potent mitotic inhibitor that exhibits significant antiproliferative activity. It effectively induces cell cycle arrest at the G2/M phase, leading to a specific and reversible mitotic arrest. Additionally, MT-7 inhibits the polymerization of cellular microtubules, making it a valuable tool for researchers investigating cell division and cancer biology. -
Microtubule/Tubulin Inhibitor
2-Methylthiophenothiazine is a potent tubulin inhibitor known for its ability to disrupt microtubule dynamics. This compound has demonstrated potential anticancer activity by inhibiting tubulin aggregation, which may ultimately affect cell proliferation and survival. It is a valuable tool for research into cancer biology and for studies focusing on microtubule-targeting therapeutics. -
Microtubule Inhibitor
T900607 is a microtubule inhibitor that disrupts microtubule polymerization, thereby exerting its anti-tumor effects. This compound has demonstrated significant potential in cancer research by inducing cell cycle arrest and apoptosis in various tumor cell lines. Its mechanism of action is valuable for investigating microtubule dynamics and exploring therapeutic strategies for cancer treatment. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-74 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 15 μM. This compound is utilized predominantly in anticancer research, providing valuable insights into microtubule dynamics and their role in cancer cell proliferation. Its inhibition of tubulin assembly makes it a valuable tool for studying pathways related to tumorigenesis and therapeutic strategies targeting cytoskeletal components. -
Tubulin Polymerization Inhibitor
Bifidenone is a potent inhibitor of tubulin polymerization, demonstrating significant antiproliferative effects across various human cancer cell lines. This compound's mechanism of action disrupts microtubule dynamics, making it a valuable tool for cancer research. Bifidenone is useful for investigating cellular processes related to mitosis and offers potential insights into therapeutic strategies targeting tumor cell proliferation. -
Tubulin Assembly Inhibitor
3,4',5-Trismethoxybenzophenone is a potent inhibitor of tubulin assembly, exhibiting an IC50 value of 2.6 µM. This compound disrupts microtubule polymerization, making it a valuable tool for studying cellular processes and the cytoskeleton. Its application ranges from investigating cancer biology to exploring mechanisms of drug resistance. -
Intermediate Reactant
Monomethyl auristatin E intermediate-6 serves as a crucial intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with established anticancer properties. MMAE is recognized for its application as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted cancer therapies. This intermediate is essential for research focused on developing effective ADCs and exploring microtubule dynamics in oncology. -
Intermediate Reactant
Monomethyl auristatin E intermediate-17 serves as a crucial intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with significant anticancer activity. MMAE is prominently utilized as the cytotoxic agent in antibody-drug conjugates (ADCs), facilitating targeted cancer therapies. The development and study of this intermediate are essential for advancing ADC research and optimizing therapeutic efficacy. -
Intermediate Reactant
Monomethyl auristatin E intermediate-5 is an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor recognized for its anticancer activity. MMAE serves as a key cytotoxic component in antibody-drug conjugates (ADCs), which are increasingly utilized in targeted cancer therapies. The utility of this intermediate supports the development of innovative ADC strategies for effective cancer treatment. -
Amino acid residues of Dolastatin 12
N-Boc-dolaproine-amide-Me-Phe is a derivative of the amino acid residue found in the pentapeptide Dolastatin 10, which primarily targets tubulin polymerization. This compound exhibits significant antitumor activity through its inhibition of mitosis. It is suitable for research applications focused on cancer biology and the study of microtubule dynamics. -
Tubulin Inhibitor
NSC 145669 is a potent inhibitor of tubulin polymerization, demonstrating an IC50 of 1.7 μM. This compound exhibits significant cytotoxic effects on various cancer cell lines and has shown promising antileukemic activity in murine models. NSC 145669 serves as a valuable tool for research focused on cancer biology, particularly in the study of microtubule dynamics and therapeutic strategies targeting tubulin. -
Microtubule Polymerization Inhibitor
N-Deacetylcolchicine is a potent inhibitor of microtubule polymerization, exhibiting an IC50 of 3 μM against bovine brain microtubules. As a derivative of colchicine, it effectively activates the GTPase activity of microtubules, making it valuable for research related to cancer biology and treatment mechanisms. This compound offers significant potential for studies focusing on microtubule dynamics and their role in cancer cell proliferation. -
TTK/Mps1 Inhibitor
Luvixasertib hydrochloride is a highly selective inhibitor of TTK/Mps1, demonstrating an IC50 of 1.7 nM for TTK in vitro. This compound exhibits significant anti-cancer activity, making it a valuable tool for cancer research. Its mechanism of action targets crucial mitotic processes, providing insights into cell cycle regulation and tumorigenesis. Luvixasertib hydrochloride is suitable for studies focused on cancer biology and therapeutic development. -
MPS1 Inhibitor
CFI-401980 is a selective inhibitor of the MPS1 kinase, exhibiting an affinity characterized by a Ki value of 0.8 nM. This compound effectively inhibits the proliferation of HCT116 cancer cell lines, making it a valuable tool in cancer research. CFI-401980 may be utilized to investigate the role of MPS1 in cell cycle regulation and its potential as a therapeutic target in anti-cancer strategies. -
Mps1 Inhibitor
TC-Mps1-12 is a highly selective inhibitor of monopolar spindle 1 (Mps1), demonstrating an IC50 of 6.4 nM. It effectively disrupts the function of Mps1, a key regulator of the mitotic spindle assembly checkpoint. This compound is valuable for studying cell cycle regulation, mitosis, and cancer biology, facilitating research into potential therapeutic targets for cancer treatment. -
TTK Inhibitor
NTRC 0066-0 is a potent inhibitor of threonine-tyrosine kinase (TTK), exhibiting an IC50 of 0.9 nM. This selective inhibitor is valuable for cancer research, offering insights into TTK-mediated signaling pathways and their role in tumorigenesis. NTRC 0066-0 enables the exploration of TTK's contribution to cell cycle regulation and cancer cell proliferation. -
MPS1 Inhibitor
Mps1-IN-7 is a potent inhibitor of MPS1 with an IC50 value of 0.020 μM, demonstrating selectivity over JNK1 and JNK2 (IC50 values of 0.11 μM and 0.22 μM, respectively). This compound exhibits significant antiproliferative effects across various cancer cell lines, including SW620, CAL51, Miapaca-2, and RMG1, with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM, respectively. Mps1-IN-7 can be utilized in research focused on cell cycle regulation and the development of targeted cancer therapies. -
MPS1/TTK Inhibitor
RMS-07 is a covalent inhibitor of Monopolar Spindle Kinase 1 (MPS1/TTK), exhibiting an apparent IC50 of 13.1 nM. It selectively targets a poorly conserved cysteine residue within the kinase's hinge region. This compound is utilized in research applications focusing on cell cycle regulation, mitotic checkpoint studies, and cancer therapeutics. -
Mps1 Inhibitor
Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1, with an IC50 value of 50 nM. This compound effectively inhibits the proliferation of glioblastoma cells and enhances the sensitivity of glioblastomas to Vincristine in orthotopic glioblastoma xenograft models. Mps1-IN-3 hydrochloride is valuable for research applications targeting cell cycle regulation and glioblastoma treatment strategies. -
Mps1 Inhibitor
Mps1-IN-10 is a potent inhibitor of Mps1, exhibiting an IC50 of 6.4 nM. This compound effectively suppresses the proliferation of cancer cells, demonstrated by a GI50 of 11 nM in the MDA-MB-231 cell line. Mps1-IN-10 also shows significant anti-tumor efficacy in preclinical models using MDA-MB-231 xenografts, making it a valuable tool for cancer research applications focused on cell cycle regulation and tumor growth inhibition. -
TTK Inhibitor
TTK Inhibitor 3 is a highly potent and selective inhibitor of TTK, a critical enzyme involved in the spindle assembly checkpoint. With an IC50 value of 3.0 nM, this compound effectively disrupts TTK activity, making it a valuable tool for studying cell cycle regulation and mitotic progression. Its application extends to research focused on cancer biology, particularly in the context of therapeutic approaches targeting aberrant cell division. -
Mps1 Inhibitor
Mps1-IN-1 dihydrochloride is a potent ATP-competitive inhibitor of Mps1 kinase, exhibiting an IC50 of 367 nM. This compound effectively inhibits Mps1 mitotic kinase activity, disrupting spindle assembly checkpoint (SAC) function and leading to compromised cell cycle regulation. Mps1-IN-1 dihydrochloride demonstrates cytotoxic effects in various cellular contexts, impacting both cancerous and normal cells, making it a valuable tool for research in cell division and cancer therapy. -
Mps1 Inhibitor
Mps1-IN-6 is a selective inhibitor of Mps1, exhibiting an IC50 value of 2.596 nM. This compound demonstrates significant antiproliferative effects and shows potential as an effective antitumor agent. Mps1-IN-6 is valuable for research into tumor biology and potential therapeutic interventions targeting mitotic checkpoint regulation. -
Mps1 Inhibitor
Mps1-IN-4 is a selective inhibitor of Monopolar spindle 1 (Mps1), a critical kinase involved in the regulation of the mitotic checkpoint. This compound exhibits antiproliferative activity, making it a valuable tool for cancer research. Mps1-IN-4 can be utilized to investigate the role of Mps1 in cell cycle regulation and its implications in tumorigenesis. -
TTK Inhibitor
TTK inhibitor 4 is a potent inhibitor of threonine tyrosine kinase (TTK), exhibiting an IC50 value of 0.016 μM. This compound demonstrates significant anti-tumor activity, making it a valuable tool for cancer research. It is particularly relevant for studies focused on cell proliferation, apoptosis, and signal transduction pathways associated with malignancies. -
Mps1 Inhibitor
Mps1-IN-8 is a potent inhibitor of the Mps1 kinase, a key regulator of the spindle assembly checkpoint. It effectively impairs Mps1 activity, leading to mitotic disruption in cancer cells. This compound is valuable for investigating the role of Mps1 in tumorigenesis and exploring its potential as a therapeutic target in cancer research. -
TTK Inhibitor
CFI-400936 is a potent inhibitor of the TTK protein kinase, demonstrating an IC50 of 3.6 nM. This compound exhibits significant antitumor activity, making it valuable for research focused on cancer treatment and cellular proliferation studies. Its ability to modulate TTK activity positions it as a useful tool for investigating therapeutic strategies in oncology. -
Mps1 Inhibitor
ONCOII is a potent Mps1 inhibitor with an IC50 of 10.8 nM, primarily targeting the Mps1 kinase involved in cell division and checkpoint regulation. This reagent's efficacy is influenced by specific mutations in the Mps1 gene, as cells harboring such mutations show increased resistance to ONCOII. It is particularly useful in cancer research to study cell cycle dynamics and the effects of Mps1 modulation in tumorigenesis. -
MPS1 Inhibitor
Mps-BAY2b is a potent inhibitor of monopolar spindle 1 (MPS1) with an IC50 of 14 nM in human MPS1. This compound demonstrates significant anticancer activity, making it a valuable tool for cancer research. Mps-BAY2b can be utilized in studies to investigate cell cycle regulation and the mechanisms of tumor progression. -
Mps1 Inhibitor
Mps1/TTK-IN-1 is a potent Mps1 kinase inhibitor that specifically binds to the ATP-binding pocket of the enzyme with an IC50 of 9.2 nM and a Kd of 1.6 nM. It effectively inhibits Mps1 activity, including in drug-resistant mutants (C604Y and C604W) with IC50 values of 170 nM and 19 nM, respectively. By blocking the phosphorylation of the kinetochore protein KNL1, Mps1/TTK-IN-1 disrupts spindle assembly checkpoint function and hinders proper chromosome separation, ultimately inhibiting mitosis and tumor cell proliferation, making it a valuable tool for cancer research. -
αvβ6 integrin ligand
SM6.1-azide is a ligand specifically targeting the αvβ6 integrin, featuring an azide group. This reactive moiety enables click chemistry with small molecules, peptides, or siRNA that possess DBCO or alkyne functionalities, facilitating efficient pulmonary-targeted delivery. This compound is valuable for research applications focused on integrin interactions and targeted therapeutics in respiratory conditions. -
Integrin αvβ6 Ligand
Tri-SM6.1 is a tridentate small-molecule ligand that specifically targets integrin αvβ6. This compound effectively binds to integrin αvβ6 on epithelial cells, facilitating the delivery of conjugated α-ENaC RNA interference agents. Its biological activity and targeting capability make it a valuable tool for research applications focused on epithelial cell signaling and RNAi-mediated gene regulation. -
Integrin αvβ3 Binder
KAFDITYVRLKF is a selective integrin αvβ3 binder that exhibits competitive inhibitory activity. This compound is known to induce the production of matrix metalloproteinase-9 (MMP-9) and has been shown to block monocyte migration while promoting melanoma cell migration. Additionally, KAFDITYVRLKF demonstrates neuroprotective effects and enhances both motor and cognitive functions. Its applications are particularly relevant in research focused on melanoma and Parkinson's disease. -
αvβ3/αvβ5 Integrin Antagonist
SU015 is an antagonist of the integrins αvβ3 and αvβ5, demonstrating comparable affinity for both targets with enhanced potency and specificity. This compound effectively inhibits αvβ3-mediated cell adhesion to fibrinogen and osteopontin, as well as αvβ5-mediated cell adhesion to vitronectin. Additionally, SU015 exhibits significant inhibitory effects on FGF2-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Its properties allow for potential applications in tumor metastasis studies, and it features a linker arm suitable for radioisotope conjugation, serving as a target-specific radioreagent when labeled with isotopes such as 90Y or 177Lu. -
Integrin αvβ3 Binder
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide that selectively binds to integrin αvβ3. When radiolabeled with 99mTc, it functions as a specific radiotracer, facilitating single-photon emission computed tomography (SPECT) imaging of integrin αvβ3 expression. This compound is useful in researching angiogenesis, cancer diagnostics, and targeted therapy applications.
