Catalog No.
Product Name
Application
Product Information
Citations
-
NO/PGE2 Inhibitor
Epibetulinic acid is an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. It demonstrates significant anti-inflammatory activity, exhibiting IC50 values of 0.7 μM for NO and 0.6 μM for PGE2 in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. This compound is valuable for research applications focused on inflammation and immune response modulation. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
PGE2 Antagonist
SC-19220 is a competitive antagonist of the prostaglandin E2 receptor, demonstrating significant effects on bladder physiology. Research indicates that SC-19220 enhances bladder capacity while decreasing voiding efficiency in urethane-anesthetized rats during slow transvesical filling. Additionally, SC-19220 has been shown to restore the balance of granulocyte and monocyte production in bone marrow following burn sepsis, making it a valuable tool for investigations related to inflammatory responses and urinary tract function. -
5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
PGE2 Inhibitor
Saikogenin D is an effective PGE2 inhibitor isolated from Bupleurum chinense. This compound exhibits significant anti-inflammatory properties by activating epoxygenases, leading to the conversion of arachidonic acid into epoxyeicosanoids and dihydroxyeicosatrienoic acids, which subsequently suppress PGE2 production. Saikogenin D also induces an increase in intracellular calcium levels ([Ca2+]i) through the release of Ca2+ from intracellular stores, making it a valuable tool for studying inflammatory pathways. -
COX-2 Inhibitor
Apricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating a potent inhibitory effect on PGE2 production with an IC50 of 1.5 nM. This compound exhibits notable biological activities, including anticancer, analgesic, and anti-inflammatory properties. Apricoxib is a valuable tool for research applications focused on inflammation, pain management, and cancer therapeutics. -
PGE1 Analogue
SC 34301, an orally active PGE1 analogue, exhibits potent anti-inflammatory properties. It has been shown to significantly reduce bacterial translocation and enhance survival rates in burned mouse models. This compound is valuable for research applications focusing on inflammation, tissue repair, and the physiological effects of prostaglandin analogues. -
PGE2 Analog
Prostaglandin E2 Ethanolamide (PGE2-EA) is a biologically active analog of Prostaglandin E2, chiefly targeting the modulation of inflammatory responses. It is formed enzymatically through the COX-2-mediated oxygenation of endocannabinoids. PGE2-EA demonstrates the ability to influence the production of the pro-inflammatory cytokine TNF-α in human blood and monocytic cells, making it a valuable tool for research in inflammation and immunology. -
PGE2 Inhibitor
(+)-Oxypeucedanin methanolate is a potent inhibitor of prostaglandin E2 (PGE2) synthesis. This natural compound exhibits significant anti-inflammatory properties, making it a valuable reagent in studies focused on inflammation and pain modulation. Research applications include investigating the pathways of prostaglandin synthesis and exploring potential therapeutic interventions for inflammatory diseases. -
PGE2 Enantiomer
ent-Prostaglandin E2 (ent-PGE2) is an enantiomer of Prostaglandin E2 that serves as a poor substrate for 15-hydroxyprostaglandin dehydrogenase. This differential substrate activity can be leveraged in various biochemical studies to investigate the enzymatic pathways and regulatory mechanisms involving prostaglandins. Research applications include studying the physiological effects of PGE2 and the role of its enantiomers in inflammatory processes and cell signaling pathways. -
PGE1/PGE2 Metabolite
Tetranor-Prostaglandin E1 is a metabolite of Prostaglandin E1, resulting from β-oxidation processes. This compound serves as a crucial biomarker in studies related to prostaglandin metabolism and pathways. It is commonly utilized in research involving inflammatory responses and various physiological processes mediated by prostaglandins. -
PGE2 Precursor
Prostaglandin E2 isopropyl ester serves as a precursor for Prostaglandin E2 (PGE2). This compound is instrumental in various biological processes, including inflammation and modulation of immune responses. Researchers commonly utilize it in studies focused on prostaglandin synthesis and signaling pathways related to pain, edema, and cellular growth. Its role in mediating physiological functions makes it a valuable reagent for elucidating mechanisms in both basic and applied biomedical research. -
Nonsteroidal Anti-Inflammatory Agent
Amtolmetin guacil is a nonsteroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) to inhibit prostaglandin synthesis. It exhibits significant pain-relieving effects and has the added ability to stimulate capsaicin receptors in the gastrointestinal wall, promoting the release of gastroprotective nitric oxide (NO). This compound is particularly relevant for research focused on knee osteoarthritis and its associated inflammatory processes. -
PGE2 Antagonist
SC-42867 is a potent PGE2 antagonist, specifically designed to inhibit prostaglandin E2 signaling pathways. This compound is metabolized in the liver through mechanisms such as oxidative N-dealkylation and aromatic hydroxylation. SC-42867 is highly relevant for studies focused on metabolic conditions, allowing researchers to explore the biochemical implications of PGE2 modulation in various physiological processes. -
PGE2 Analogue
FCE 20700 is an orally active analogue of prostaglandin E2 (PGE2) that primarily targets gastric mucosal integrity. It demonstrates the ability to prevent gastric mucosal damage and inhibit both gastric acid and pepsin secretion. This compound is valuable for research into gastrointestinal ulcers and related disorders, providing insights into therapeutic strategies for gastrointestinal protection. -
NO/PGE2 Inhibitor
Salviifoside A is a phenolic glycoside that acts as an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. Isolated from the leaves of Alangium salviifolium, Salviifoside A effectively suppresses LPS-induced nitric oxide and prostaglandin E2 production in macrophages while maintaining cell viability. This compound is valuable for research focused on inflammatory responses and the modulation of macrophage activation. -
PGE2 Metabolite
13,14-Dihydro-15-keto-tetranor prostaglandin E2 is a novel metabolite of Prostaglandin E2, functioning primarily as a bioactive mediator in various physiological processes. As a key derivative, it is involved in studies exploring the metabolic pathways of prostaglandins and their implications in inflammation and other biological responses. This compound has significant applications in research focused on prostaglandin signaling and its role in disease mechanisms. -
PGE2 Analog
8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is a PGE2 analog that exhibits potent biological activity by modulating various physiological processes. It engages the prostaglandin receptors, influencing pathways related to inflammation, pain, and vascular regulation. This compound is valuable for research applications focused on the roles of prostaglandins in disease models, as well as studies investigating receptor-targeted therapies. -
Anti-Inflammatory Agent
Diftalone, an anti-inflammatory agent, primarily targets inflammatory pathways to modulate immune responses. This compound is utilized in research investigating inflammatory diseases, including rheumatoid arthritis, and offers valuable insights into potential therapeutic approaches for managing such conditions. Its efficacy in reducing inflammation makes it a pivotal tool in the study of chronic inflammatory disorders. -
PGE1 Analog
15-Methylprostaglandin E1 is an analog of prostaglandin E1 (PGE1) that primarily targets prostaglandin receptors to elicit cardiovascular effects. It demonstrates a positive chronotropic effect, leading to increased heart rate and enhanced levels of nicardipine. This compound is widely utilized in studies related to circulatory system regulation and pharmacological investigations into heart rate modulation. -
Antiinflammatory Agent
4-Oxoetodolac, a metabolite of Etodolac, acts as an orally bioavailable anti-inflammatory agent. It effectively inhibits prostaglandin production in cultured chondrocyte cells, contributing to its anti-inflammatory properties. Additionally, 4-Oxoetodolac demonstrates moderate anti-inflammatory activity in a rat adjuvant edema model. This compound is useful for research focused on inflammation and related biological processes. -
PGE2 Analog
(15S)-15-Methylprostaglandin E2 is a synthetic analog of prostaglandin E2 that primarily targets the PGE2 receptor. This compound exhibits significant biological activity by promoting cytoprotection in gastrointestinal cells and may inhibit gastrointestinal bleeding. Its applications in research include studies on inflammation, gastrointestinal health, and the pharmacological roles of prostaglandins in various biological processes. -
PGE2 Inducer
5S(6R)-EET is a metabolite derived from arachidonic acid that acts as a potent inducer of prostaglandin E2 (PGE2) synthesis. This compound enhances intracellular calcium levels and inhibits sodium absorption, contributing to membrane depolarization. Its biological activity makes it a valuable tool for research focused on the regulatory roles of prostaglandins in various physiological processes. -
PGE2 Analog
16-Phenoxy tetranor Prostaglandin E2 is an analog of prostaglandin E2 (PGE2) that serves as a potent modulator of various biological processes. This compound exhibits significant biological activity by influencing the prostaglandin pathway, making it valuable for studying inflammatory responses and reproductive biology. Additionally, its role as a minor metabolite of sulprostone in human plasma provides insights into pharmacokinetics and metabolic pathways relevant to drug development and therapeutic applications. -
COX-2/PGE2 Inducer
Rebamipide-d4 is a deuterium-labeled derivative of Rebamipide, primarily targeting cyclooxygenase-2 (COX-2). This compound induces COX-2 expression and elevates prostaglandin E2 (PGE2) levels, thereby enhancing gastric mucosal defense mechanisms in a COX-2-dependent manner. Rebamipide-d4 is utilized in various research applications focused on gastric protection and the modulation of inflammatory responses. -
PGE2 Inducer
5R(6S)-EET is a metabolite derived from arachidonic acid that functions as a PGE2 inducer. It activates the synthesis of endogenous prostaglandin E2, leading to inhibition of sodium absorption, an increase in intracellular calcium levels, and enhanced depolarization of transmembrane voltage. This compound displays stereoselectivity, exhibiting differential activity compared to its stereoisomer, 5S(6R)-EET. Its biological effects make it a valuable tool for研究 applications focusing on prostaglandin signaling and related pathways. -
PGE1 Prodrug
Ecraprost is a prodrug of prostaglandin E1, designed to enhance the bioavailability of PGE1 in therapeutic applications. It effectively inhibits platelet adhesion and macrophage infiltration, as well as the expression of proliferating cell nuclear antigen in injured arterial walls. Ecraprost is utilized in research related to cardiovascular health and vascular injury repair. -
KRASG12C Inhibitor
KRASG12C IN-12 is a selective inhibitor of the KRASG12C mutant. This compound effectively forms a ternary complex with intracellular cyclophilin A (CYPA) and the activated KRASG12C, inhibiting its downstream signaling pathways. It has significant potential for research applications related to cancer biology, particularly in studies targeting KRAS-driven tumorigenesis. -
NO Production Inhibitor
N-Phthaloyl-L-glutamic acid is a nitric oxide production inhibitor that effectively reduces lipopolysaccharide (LPS)-induced nitric oxide synthesis in murine spleen cells. This compound serves as a potential anti-inflammatory agent, demonstrating low cytotoxicity in vitro against tumor cells and in BALB/c mice spleen cell cultures. N-Phthaloyl-L-glutamic acid is suitable for research investigating mechanisms of inflammation and associated therapeutic approaches. -
Anti-inflammatory Agent
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside that acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, demonstrating 56.9% inhibition at a concentration of 25 μg/mL. This compound can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia, a member of the Rosaceae family. Due to its biological activity, it is of interest in research focused on inflammation and immune response modulation. -
Nitric oxide donor
S-Nitroso-N-acetyl-DL-penicillamine is a nitric oxide donor that serves as a stable inhibitor of platelet aggregation. It releases nitric oxide in biological systems, thereby contributing to vasodilation and modulation of inflammatory responses. This compound is widely utilized in research related to cardiovascular studies and low blood flow conditions, as well as in investigations of nitric oxide's role in cellular signaling and pathophysiology. -
NO Donor
DETA NONOate is a highly effective exogenous nitric oxide (NO) donor. It releases NO slowly and in controlled amounts, providing long-lasting effects. This compound is widely used in research applications to study NO-mediated physiological processes, such as vasodilation, neuronal signaling, and immune responses. DETA NONOate's stable release profile makes it particularly suitable for in vitro and in vivo studies investigating the role of nitric oxide in various biological systems. -
Monocarboxylic Acid Amide
Lipoamide is a monocarboxylic acid amide that serves as a crucial coenzyme in cellular metabolism, facilitating the transfer of acetyl groups and hydrogen during pyruvate decarboxylation. This compound exhibits protective effects against oxidative stress-induced neuronal cell damage. Additionally, lipoamide plays a significant role in promoting mitochondrial biogenesis in adipocytes through the endothelial nitric oxide synthase-cGMP-protein kinase G signaling pathway, making it valuable for research in metabolic disorders and neuroprotection. -
Porphyrin Complex
Ferroheme is the ferrous form of heme that functions primarily as an oxygen carrier through reversible oxygen binding. Its free form is known to induce oxidative stress and ferroptosis by releasing iron ions, which facilitate the generation of reactive oxygen species via Fenton reactions. This mechanism plays a significant role in pathological conditions such as intracerebral hemorrhage and neurodegenerative diseases, making Ferroheme a valuable reagent for research into iron-overload disorders and the mechanisms underlying ferroptosis-related pathologies. -
NO Inhibitor
Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that facilitates the rapid reaction with NO to yield nitrogen dioxide (NO2). This compound exhibits significant biological activity by preventing hypotension and alleviating endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. It serves as a valuable reagent for researchers investigating the role of nitric oxide in various physiological and pathophysiological processes. -
Glycosaminoglycan
Chondroitin sulfate sodium (from shark cartilage) is a glycosaminoglycan that plays a critical role in cartilage structure and function. It exhibits significant anti-inflammatory properties by reducing the production of inflammatory cytokines, inducible nitric oxide synthase (iNOS), and matrix metalloproteinases (MMPs). This compound is commonly investigated in therapeutic research focused on osteoarthritis and other joint disorders, where it supports cartilage health and alleviates symptoms associated with inflammation. -
NO Scavenger
PTIO is a selective nitric oxide (NO) scavenger and redox mediator. It reacts with nitric oxide to produce imino nitroxides and nitrogen dioxide, effectively mitigating the effects of NO in biological systems. PTIO also enhances the oxidation of organic contaminants by permanganate, making it valuable in studies involving redox chemistry and environmental research. Its applications include investigating NO-related signaling pathways and assessing oxidative stress in various biological contexts. -
NOS Uncoupling Inducer
7,8-Dihydro-L-biopterin serves as a nitric oxide synthase (NOS) uncoupling inducer and is capable of crossing the blood-brain barrier. As a reduced, non-conjugated pteridine and the primary metabolite of 4-amino-tetrahydro-L-biopterin, it promotes the conversion of NOS to a superoxide-producing form, elevating oxidative stress levels, particularly in the renal outer medulla, and triggering apoptosis. This compound's sensitivity to superoxide dismutase (SOD) inhibition makes it valuable for research into salt-sensitive hypertension, traumatic brain injury, and neurodegenerative diseases. -
NO Donor
Spermine NONOate is a nitric oxide (NO) donor characterized by its ability to release NO in aqueous solutions. This compound facilitates various biological processes, including vasodilation and signaling pathways associated with cardiovascular health. Spermine NONOate is commonly utilized in research applications focusing on nitric oxide's role in cellular communication and its implications in various physiological and pathological conditions. -
NO Synthase Inhibitor
L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). It demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying inflammatory pathways and the role of iNOS in various disease models. This compound is utilized in research applications focused on neurodegeneration, cancer, and cardiovascular disease, providing insights into the mechanisms of nitric oxide-mediated signaling. -
iNOS Inhibitor
Asperuloside is an iridoid compound derived from Hedyotis diffusa, primarily known for its role as an inducible nitric oxide synthase (iNOS) inhibitor. This compound exhibits notable anti-inflammatory properties by suppressing the NF-κB and MAPK signaling pathways. Asperuloside is valuable in studying inflammatory processes and developing therapeutic strategies for related diseases. -
Nrf2 Activator
RA839 is a selective activator of the Nrf2/ARE pathway, functioning as a non-covalent small molecule binder of Keap1 with a Kd of approximately 6 μM. This compound inhibits the expression of inducible nitric oxide synthase and the subsequent release of nitric oxide. RA839 demonstrates significant anti-rotaviral and anti-inflammatory properties, making it a valuable tool for research into oxidative stress, viral infections, and inflammation-related pathways. -
Nitrogen Donor
L-Arginine L-glutamate serves as a critical nitrogen donor for the synthesis of nitric oxide, a key signaling molecule in various biological processes. This compound is valuable in studying gastrointestinal hypofunction or dysfunction, including conditions such as functional dyspepsia. Its role in modulating nitric oxide levels makes it significant for research into cardiovascular health and metabolic regulation. -
NO Donor
MAHMA NONOate is a nitric oxide (NO) donor that facilitates the release of NO in biological systems. It demonstrates significant inhibitory effects on platelet aggregation induced by collagen or ADP, making it valuable for research related to cardiovascular physiology and thrombosis. This compound is useful for studying the mechanisms of NO signaling in various biological contexts. -
CaV1.2 Channel Inhibitor
Demethylsuberosin, a coumarin derivative isolated from Angelica gigas Nakai, primarily targets the L-type CaV1.2 channel as an inhibitor. This compound demonstrates significant antihypertensive effects, in addition to possessing antioxidant and anti-inflammatory properties. Notably, Demethylsuberosin offers neuroprotective effects against glutamate-induced cytotoxicity in primary cultured rat cortical cells, making it a valuable reagent for research in cardiovascular and neurological studies. -
Cyanide Antidote
Hydroxocobalamin acetate is a derivative of vitamin B12 that acts as an effective cyanide antidote. It works by binding to nitric oxide and facilitating the detoxification of cyanide and sodium sulfide. Additionally, hydroxocobalamin acetate has been shown to mitigate hypotension. This compound is utilized in research pertaining to vitamin B12 deficiency disorders, including pernicious anemia. -
iNOS Inhibitor
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. -
Anti-inflammatory Drug
Regaloside A is a phenylpropanoid with notable anti-inflammatory properties. It demonstrates significant DPPH radical scavenging activity, with a measured efficacy of 58.0% at a concentration of 160 ppm. This compound is useful in investigating anti-inflammatory mechanisms and for potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Ciwujianoside C3 is an orally active compound that functions as an anti-inflammatory agent. Isolated from the leaves of Acanthopanax henryi Harms, this reagent demonstrates significant anti-inflammatory properties while also enhancing object recognition memory. Its biological activity supports research in neuroprotection and cognitive enhancement studies. -
NO Synthase Inhibtior
NG-nitro-L-arginine is a potent nitric oxide synthase (NOS) inhibitor, demonstrating inhibitory constants (Kis) of 0.61 μM for neuronal NOS (nNOS), 4.28 μM for inducible NOS (iNOS), and 0.72 μM for endothelial NOS (eNOS). This compound effectively inhibits the formation and release of endothelium-derived relaxing factor (EDRF), making it a valuable tool in cardiovascular research. NG-nitro-L-arginine has been shown to reduce portal-systemic shunting in portal-hypertensive rat models and is associated with increased blood pressure, thereby serving as a key reagent for studies investigating vascular function and regulation.
