FEN1-IN-1 is a selective inhibitor of flap endonuclease 1 (FEN1), demonstrating significant antitumor activity. It functions by binding to the active site of FEN1, with inhibition partially facilitated by the coordination of Mg2+ ions. This compound triggers a DNA damage response, subsequently activating the ATM checkpoint signaling pathway, leading to the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is a valuable tool for cancer research, particularly in studies focused on DNA repair mechanisms and tumor progression.
FEN1-IN-1 is a selective inhibitor of flap endonuclease 1 (FEN1), demonstrating significant antitumor activity. It functions by binding to the active site of FEN1, with inhibition partially facilitated by the coordination of Mg2+ ions. This compound triggers a DNA damage response, subsequently activating the ATM checkpoint signaling pathway, leading to the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is a valuable tool for cancer research, particularly in studies focused on DNA repair mechanisms and tumor progression.
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