Gemtuzumab is a monoclonal IgG4-κ antibody that targets the CD33 antigen. This antibody mediates cell necrosis by specifically binding to CD33 expressed on leukemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab serves as a precursor for the synthesis of antibody-drug conjugates, such as Gemtuzumab ozogamicin, which combines a cytotoxic derivative of Calicheamicin with the antibody. It is utilized in research applications focused on understanding and treating acute myeloid leukemia.
Gemtuzumab is a monoclonal IgG4-κ antibody that targets the CD33 antigen. This antibody mediates cell necrosis by specifically binding to CD33 expressed on leukemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab serves as a precursor for the synthesis of antibody-drug conjugates, such as Gemtuzumab ozogamicin, which combines a cytotoxic derivative of Calicheamicin with the antibody. It is utilized in research applications focused on understanding and treating acute myeloid leukemia.
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