Catalog No.
Product Name
Application
Product Information
Citations
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PGE1 Prodrug
Ecraprost is a prodrug of prostaglandin E1, designed to enhance the bioavailability of PGE1 in therapeutic applications. It effectively inhibits platelet adhesion and macrophage infiltration, as well as the expression of proliferating cell nuclear antigen in injured arterial walls. Ecraprost is utilized in research related to cardiovascular health and vascular injury repair. -
KRASG12C Inhibitor
KRASG12C IN-12 is a selective inhibitor of the KRASG12C mutant. This compound effectively forms a ternary complex with intracellular cyclophilin A (CYPA) and the activated KRASG12C, inhibiting its downstream signaling pathways. It has significant potential for research applications related to cancer biology, particularly in studies targeting KRAS-driven tumorigenesis. -
CXCR6 Antagonist
ML339 is a selective antagonist of the CXCR6 receptor, displaying an IC50 of 140 nM. It inhibits β-arrestin recruitment and the cAMP signaling pathway induced by CXCL16 in human CXCR6, with IC50 values of 0.3 μM and 1.4 μM, respectively. While exhibiting reduced efficacy against mouse CXCR6 with an IC50 of 18 μM, ML339 demonstrates no significant inhibition of CXCR5, CXCR4, or the apelin receptor (APJ), with IC50 values exceeding 79 μM. This compound shows promise for advancing research focused on prostate cancer. -
CXCR Inhibitor
ALX 40-4C is a small peptide inhibitor targeting the chemokine receptor CXCR4. It effectively prevents the binding of SDF-1 to CXCR4 with a Ki of 1 μM, thereby inhibiting the replication of X4 strains of HIV-1. Additionally, ALX 40-4C Trifluoroacetate serves as an antagonist of the APJ receptor, exhibiting an IC50 value of 2.9 μM. This dual activity makes ALX 40-4C a valuable tool for research in HIV-1 studies and chemokine receptor signaling pathways. -
CCR6 Antagonist
IDOR-1117-2520 is a potent and selective reversible antagonist targeting CCR6. It effectively inhibits CCL20-mediated calcium influx with an IC50 of 63 nM and blocks β-arrestin recruitment to human CCR6, showing an IC50 of 30 nM in recombinant cell models. As a substrate of P-glycoprotein/MDR1, IDOR-1117-2520 is a valuable tool for investigating autoimmune diseases and skin inflammation in research settings. -
CXCR Receptor Inhibitor
SCH-900875 is a selective inhibitor of the CXCR3 receptor, known for its oral bioavailability and ability to penetrate the blood-brain barrier. By binding to CXCR3, it effectively prevents the interaction of ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways, which reduces inflammatory cell migration. This compound holds potential for investigating various autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, as well as inflammatory conditions like psoriasis and inflammatory bowel disease. -
Anti-inflammatory agent
Emorfazone is a non-steroidal anti-inflammatory drug that functions primarily through the inhibition of bradykinin-like substances and kininogen release. This compound exhibits notable anti-inflammatory and analgesic properties, making it a valuable tool for research on pain management and inflammatory conditions. Its oral activity further expands its application in pharmacological studies aimed at understanding inflammatory pathways. -
Non-steroidal Anti-inflammatory Agent
Zoliprofen is a non-steroidal anti-inflammatory agent that primarily acts by antagonizing bradykinin, leading to significant suppression of bradykinin-induced edema and pain responses. It also exhibits a moderate inhibitory effect on arachidonic acid-induced edema and pain, while additionally inhibiting PGE2 synthesis in bovine vesicular gland microsomes. This dual action makes Zoliprofen a valuable tool for research applications focused on pain management and inflammatory processes. -
CETP Inhibitor/CB1 Agonist
BI-5756 is a selective CETP inhibitor and cannabinoid receptor 1 (CB1) agonist. It promotes a significant increase in HDL-C levels while reducing LDL-C levels, thereby improving lipid profiles. Additionally, BI-5756 enhances the function of regulatory T cells and preserves T cell-mediated anti-tumor activity, exhibiting direct anti-proliferative effects on tumor cells. This compound also upregulates the expression of MHC I, MHC II, and CD80 on tumor cells and demonstrates protective effects in graft-versus-host disease. BI-5756 is applicable in research related to oncology, graft-versus-host disease, and metabolic disorders. -
CB1R/iNOS Antagonist
(Rac)-Zevaquenabant is a potent cannabinoid receptor type 1 (CB1R) and iNOS antagonist, exhibiting a Ki value of 5.7 nM for CB1R. This compound is primarily utilized in studies related to liver fibrosis, providing valuable insights into its pathophysiology and potential therapeutic interventions. Its selective inhibition of CB1R and iNOS pathways makes it a significant tool for investigating cannabinoid signaling and its implications in fibrotic diseases. -
CXCR7 Antagonist
CXCR7 antagonist-1 functions as a CXCR7 antagonist by inhibiting the binding of the SDF-1 (CXCL12) and I-TAC (CXCL11) chemokines to the CXCR7 receptor. This inhibition plays a critical role in suppressing tumor cell proliferation and tumor growth, thereby providing potential therapeutic applications in cancer treatment. Additionally, CXCR7 antagonist-1 may be beneficial in the study and management of various inflammatory diseases and other pathologies associated with the CXCR7 pathway. -
NO Production Inhibitor
N-Phthaloyl-L-glutamic acid is a nitric oxide production inhibitor that effectively reduces lipopolysaccharide (LPS)-induced nitric oxide synthesis in murine spleen cells. This compound serves as a potential anti-inflammatory agent, demonstrating low cytotoxicity in vitro against tumor cells and in BALB/c mice spleen cell cultures. N-Phthaloyl-L-glutamic acid is suitable for research investigating mechanisms of inflammation and associated therapeutic approaches. -
Anti-inflammatory Agent
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside that acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, demonstrating 56.9% inhibition at a concentration of 25 μg/mL. This compound can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia, a member of the Rosaceae family. Due to its biological activity, it is of interest in research focused on inflammation and immune response modulation. -
Nitric oxide donor
S-Nitroso-N-acetyl-DL-penicillamine is a nitric oxide donor that serves as a stable inhibitor of platelet aggregation. It releases nitric oxide in biological systems, thereby contributing to vasodilation and modulation of inflammatory responses. This compound is widely utilized in research related to cardiovascular studies and low blood flow conditions, as well as in investigations of nitric oxide's role in cellular signaling and pathophysiology. -
NO Donor
DETA NONOate is a highly effective exogenous nitric oxide (NO) donor. It releases NO slowly and in controlled amounts, providing long-lasting effects. This compound is widely used in research applications to study NO-mediated physiological processes, such as vasodilation, neuronal signaling, and immune responses. DETA NONOate's stable release profile makes it particularly suitable for in vitro and in vivo studies investigating the role of nitric oxide in various biological systems. -
Monocarboxylic Acid Amide
Lipoamide is a monocarboxylic acid amide that serves as a crucial coenzyme in cellular metabolism, facilitating the transfer of acetyl groups and hydrogen during pyruvate decarboxylation. This compound exhibits protective effects against oxidative stress-induced neuronal cell damage. Additionally, lipoamide plays a significant role in promoting mitochondrial biogenesis in adipocytes through the endothelial nitric oxide synthase-cGMP-protein kinase G signaling pathway, making it valuable for research in metabolic disorders and neuroprotection. -
Porphyrin Complex
Ferroheme is the ferrous form of heme that functions primarily as an oxygen carrier through reversible oxygen binding. Its free form is known to induce oxidative stress and ferroptosis by releasing iron ions, which facilitate the generation of reactive oxygen species via Fenton reactions. This mechanism plays a significant role in pathological conditions such as intracerebral hemorrhage and neurodegenerative diseases, making Ferroheme a valuable reagent for research into iron-overload disorders and the mechanisms underlying ferroptosis-related pathologies. -
NO Inhibitor
Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that facilitates the rapid reaction with NO to yield nitrogen dioxide (NO2). This compound exhibits significant biological activity by preventing hypotension and alleviating endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. It serves as a valuable reagent for researchers investigating the role of nitric oxide in various physiological and pathophysiological processes. -
Glycosaminoglycan
Chondroitin sulfate sodium (from shark cartilage) is a glycosaminoglycan that plays a critical role in cartilage structure and function. It exhibits significant anti-inflammatory properties by reducing the production of inflammatory cytokines, inducible nitric oxide synthase (iNOS), and matrix metalloproteinases (MMPs). This compound is commonly investigated in therapeutic research focused on osteoarthritis and other joint disorders, where it supports cartilage health and alleviates symptoms associated with inflammation. -
NO Scavenger
PTIO is a selective nitric oxide (NO) scavenger and redox mediator. It reacts with nitric oxide to produce imino nitroxides and nitrogen dioxide, effectively mitigating the effects of NO in biological systems. PTIO also enhances the oxidation of organic contaminants by permanganate, making it valuable in studies involving redox chemistry and environmental research. Its applications include investigating NO-related signaling pathways and assessing oxidative stress in various biological contexts. -
NOS Uncoupling Inducer
7,8-Dihydro-L-biopterin serves as a nitric oxide synthase (NOS) uncoupling inducer and is capable of crossing the blood-brain barrier. As a reduced, non-conjugated pteridine and the primary metabolite of 4-amino-tetrahydro-L-biopterin, it promotes the conversion of NOS to a superoxide-producing form, elevating oxidative stress levels, particularly in the renal outer medulla, and triggering apoptosis. This compound's sensitivity to superoxide dismutase (SOD) inhibition makes it valuable for research into salt-sensitive hypertension, traumatic brain injury, and neurodegenerative diseases. -
NO Donor
Spermine NONOate is a nitric oxide (NO) donor characterized by its ability to release NO in aqueous solutions. This compound facilitates various biological processes, including vasodilation and signaling pathways associated with cardiovascular health. Spermine NONOate is commonly utilized in research applications focusing on nitric oxide's role in cellular communication and its implications in various physiological and pathological conditions. -
NO Synthase Inhibitor
L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). It demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying inflammatory pathways and the role of iNOS in various disease models. This compound is utilized in research applications focused on neurodegeneration, cancer, and cardiovascular disease, providing insights into the mechanisms of nitric oxide-mediated signaling. -
iNOS Inhibitor
Asperuloside is an iridoid compound derived from Hedyotis diffusa, primarily known for its role as an inducible nitric oxide synthase (iNOS) inhibitor. This compound exhibits notable anti-inflammatory properties by suppressing the NF-κB and MAPK signaling pathways. Asperuloside is valuable in studying inflammatory processes and developing therapeutic strategies for related diseases. -
Nrf2 Activator
RA839 is a selective activator of the Nrf2/ARE pathway, functioning as a non-covalent small molecule binder of Keap1 with a Kd of approximately 6 μM. This compound inhibits the expression of inducible nitric oxide synthase and the subsequent release of nitric oxide. RA839 demonstrates significant anti-rotaviral and anti-inflammatory properties, making it a valuable tool for research into oxidative stress, viral infections, and inflammation-related pathways. -
Nitrogen Donor
L-Arginine L-glutamate serves as a critical nitrogen donor for the synthesis of nitric oxide, a key signaling molecule in various biological processes. This compound is valuable in studying gastrointestinal hypofunction or dysfunction, including conditions such as functional dyspepsia. Its role in modulating nitric oxide levels makes it significant for research into cardiovascular health and metabolic regulation. -
NO Donor
MAHMA NONOate is a nitric oxide (NO) donor that facilitates the release of NO in biological systems. It demonstrates significant inhibitory effects on platelet aggregation induced by collagen or ADP, making it valuable for research related to cardiovascular physiology and thrombosis. This compound is useful for studying the mechanisms of NO signaling in various biological contexts. -
CaV1.2 Channel Inhibitor
Demethylsuberosin, a coumarin derivative isolated from Angelica gigas Nakai, primarily targets the L-type CaV1.2 channel as an inhibitor. This compound demonstrates significant antihypertensive effects, in addition to possessing antioxidant and anti-inflammatory properties. Notably, Demethylsuberosin offers neuroprotective effects against glutamate-induced cytotoxicity in primary cultured rat cortical cells, making it a valuable reagent for research in cardiovascular and neurological studies. -
Cyanide Antidote
Hydroxocobalamin acetate is a derivative of vitamin B12 that acts as an effective cyanide antidote. It works by binding to nitric oxide and facilitating the detoxification of cyanide and sodium sulfide. Additionally, hydroxocobalamin acetate has been shown to mitigate hypotension. This compound is utilized in research pertaining to vitamin B12 deficiency disorders, including pernicious anemia. -
iNOS Inhibitor
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. -
Anti-inflammatory Drug
Regaloside A is a phenylpropanoid with notable anti-inflammatory properties. It demonstrates significant DPPH radical scavenging activity, with a measured efficacy of 58.0% at a concentration of 160 ppm. This compound is useful in investigating anti-inflammatory mechanisms and for potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Ciwujianoside C3 is an orally active compound that functions as an anti-inflammatory agent. Isolated from the leaves of Acanthopanax henryi Harms, this reagent demonstrates significant anti-inflammatory properties while also enhancing object recognition memory. Its biological activity supports research in neuroprotection and cognitive enhancement studies. -
NO Synthase Inhibtior
NG-nitro-L-arginine is a potent nitric oxide synthase (NOS) inhibitor, demonstrating inhibitory constants (Kis) of 0.61 μM for neuronal NOS (nNOS), 4.28 μM for inducible NOS (iNOS), and 0.72 μM for endothelial NOS (eNOS). This compound effectively inhibits the formation and release of endothelium-derived relaxing factor (EDRF), making it a valuable tool in cardiovascular research. NG-nitro-L-arginine has been shown to reduce portal-systemic shunting in portal-hypertensive rat models and is associated with increased blood pressure, thereby serving as a key reagent for studies investigating vascular function and regulation. -
NO Synthase Inhibitor
Kuwanon A is a flavone derivative that serves as an inhibitor of nitric oxide synthase. It effectively reduces nitric oxide production with an IC50 of 10.5 μM. This compound is relevant for research applications investigating vascular function, inflammatory processes, and the pathophysiology of various diseases linked to nitric oxide signaling. -
NOS Inhibitor
S-MTC dihydrochloride is a selective inhibitor of type I nitric oxide synthase (NOS). It effectively reduces nitric oxide production, making it a valuable tool for studies investigating the role of NOS in various physiological and pathological processes. This compound is commonly utilized in research applications related to cardiovascular health, neurobiology, and inflammation. -
nNOS Inhibitor
Nω-Propyl-L-arginine is a highly selective and potent competitive inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 57 nM. With a 149-fold selectivity for nNOS over endothelial nitric oxide synthase (eNOS), this compound is invaluable for studying nNOS-related pathways and neurobiology. Its use is pertinent in elucidating the role of nNOS in various physiological and pathological processes, making it a crucial reagent for research applications in neuroscience and pharmacology. -
nitric oxide synthase Inhibitor
Aminopicoline is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes, including iNOS, nNOS, and eNOS. By competing with arginine at the substrate-binding site, it effectively reduces cellular nitric oxide production and inhibits the elevation of plasma nitrate levels, which can influence mean arterial pressure. This compound serves as a valuable tool in research focused on diseases related to septic shock, joint and intestinal inflammation, as well as central nervous system (CNS) inflammation. -
NO Synthase Antagonist
L-NMMA (N-methyl-L-arginine) is a competitive antagonist of L-arginine that effectively inhibits the production of nitric oxide (NO) by targeting nitric oxide synthase. This compound is employed in various experimental studies to investigate the physiological and pathological roles of NO and its signaling pathways. Its application extends to cardiovascular research, neurobiology, and studies involving vascular function. -
NOS3 Inhibitors
Kihadanin A is a limonoid that functions as an inhibitor of nitric oxide synthase 3 (NOS3). Isolated from the methanol extract of Dictamnus dasycarpus root bark, Kihadanin A demonstrates potential therapeutic applications in the study of hyperuricemia (HUA). This compound can be utilized in research aimed at understanding the biochemical pathways related to nitric oxide production and its implications in various physiological conditions. -
NOS Inhibitor
nNOS-IN-1 is a selective inhibitor of nitric oxide synthases (NOS), demonstrating potent inhibitory activity against neuronal, inducible, and endothelial NOS with IC50 values of 2.5, 5.7, and 13 μM, respectively. This compound serves as a valuable tool for elucidating the roles of nitric oxide in various biological processes and has potential applications in neurobiology and cardiovascular research. By selectively targeting NOS, nNOS-IN-1 can aid in the investigation of pathological conditions associated with dysregulated nitric oxide signaling. -
nNOS Inhibitor
Nω-Propyl-L-arginine hydrochloride is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a competitive inhibition profile with a Ki value of 57 nM. This compound offers significant selectivity, displaying a 149-fold preference for nNOS over endothelial nitric oxide synthase (eNOS). Nω-Propyl-L-arginine hydrochloride is primarily utilized in research applications focused on the modulation of nitric oxide pathways and the study of nNOS-related physiological and pathological processes. -
NO Synthase Inhibitor
2-Iminobiotin hydrobromide is a reversible inhibitor of nitric oxide synthase (NOS), specifically exhibiting Kis of 21.8 μM for murine inducible NOS (iNOS) and 37.5 μM for rat neuronal NOS (n-cNOS). This compound has demonstrated potential neuroprotective effects, providing protection to human neuronal cells against hypoxia-induced cell damage. It is valuable for research in neurobiology and the study of nitric oxide signaling pathways. -
iNOS Inhibitor
AR-C102222 hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS) with a competitive mechanism of action. Demonstrating an IC50 of 37 nM, it exhibits notable antinociceptive and anti-inflammatory properties. This compound is valuable for research into pain modulation and inflammatory diseases, providing insights into the role of nitric oxide in these biological processes. -
Anti-inflammatory Drug
Ikarisoside A is a natural flavonol glycoside known for its anti-inflammatory properties. This compound exhibits significant activity in reducing inflammation, making it valuable for research focused on inflammatory diseases and related therapeutic applications. Its mechanism of action may involve the modulation of inflammatory pathways, providing insights for the development of new anti-inflammatory treatments. -
iNOS Inhibitor
BBS-4 is a highly potent and selective inhibitor of inducible nitric oxide synthase (iNOS, NOS2) dimerization, demonstrating an IC50 of 0.49 nM. This compound is primarily utilized in research focused on cardiovascular dysfunction, notably offering protective effects in murine models of sepsis. Its selective inhibition of iNOS makes BBS-4 a valuable tool for investigating nitric oxide-related pathologies and potential therapeutic interventions. -
Substrate for NO Synthase
L-Hydroxy arginine dihydrochloride is a substrate for nitric oxide synthase (NOS), playing a crucial role in the production of nitric oxide from L-arginine. This compound is utilized in biochemical research to investigate the enzymatic pathways of NO synthesis and its physiological implications. Its applications extend to studies exploring vascular function, signal transduction, and the impact of nitric oxide in various biological systems. -
nNOS Inhibitor
NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms. -
NO Synthase Inhibitor
NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes. -
NOS Inhibitor
TRIM is a potent nitric oxide synthase (NOS) inhibitor, selectively targeting neuronal nitric oxide synthase (nNOS) in mouse cerebellar samples and inducible nitric oxide synthase (iNOS) in rat lung tissues, with IC50 values of 28.2 µM and 27.0 µM, respectively. This compound exhibits significant antidepressant and anxiolytic-like properties, making it valuable for research into depression and anxiety disorders. TRIM serves as an important tool for investigations into NOS-related pathways and their implications in neuropsychiatric conditions. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-1 is a potent inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (KD) of 4.4 nM. This cyclic peptide demonstrates resistance to proteolytic degradation by pepsin, trypsin, and α-chymotrypsin, ensuring stability in biological environments. Additionally, it maintains stability in human plasma and oxidative conditions, making it a valuable tool for studying iNOS-related pathways in inflammation and other biological processes.
