AH1 is an MHC class I-restricted tumor-specific antigenic peptide that engages the murine MHC class I molecule Ld. Derived from the envelope protein (gp70) of the endogenous ecotropic murine leukemia virus (MuLV), AH1 serves as an immunodominant CTL epitope in CT26 colon carcinoma and TS/A murine mammary adenocarcinoma. The specific CTLs that recognize AH1 can effectively mediate cytotoxicity, leading to tumor cell killing and rejection. This peptide is valuable for research applications targeting tumor immunology and the development of cancer immunotherapies.
AH1 is an MHC class I-restricted tumor-specific antigenic peptide that engages the murine MHC class I molecule Ld. Derived from the envelope protein (gp70) of the endogenous ecotropic murine leukemia virus (MuLV), AH1 serves as an immunodominant CTL epitope in CT26 colon carcinoma and TS/A murine mammary adenocarcinoma. The specific CTLs that recognize AH1 can effectively mediate cytotoxicity, leading to tumor cell killing and rejection. This peptide is valuable for research applications targeting tumor immunology and the development of cancer immunotherapies.
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