Roflumilast-d3 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. It exhibits high specificity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while showing no inhibition on PDE1, PDE2, PDE3, or PDE5 isoenzymes. This stable isotope is valuable for research applications involving the study of PDE4-dependent signaling pathways and drug metabolism.
Roflumilast-d3 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. It exhibits high specificity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while showing no inhibition on PDE1, PDE2, PDE3, or PDE5 isoenzymes. This stable isotope is valuable for research applications involving the study of PDE4-dependent signaling pathways and drug metabolism.
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