D-Arabinose-13C-3 is a stable isotope-labeled form of D-Arabinose, an aldopentose sugar. It acts as a selective metabolic inhibitor, showing antidepressant properties and growth inhibition in C. elegans with an IC50 of 7.5 mM. D-Arabinose can penetrate the blood-brain barrier, influencing the metabolism of D-ribose and D-fructose, and exhibits antibacterial effects by inhibiting cell biofilm synthesis. Its mechanism involves activation of the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, which induces CRTC1 transcription and contributes to its antidepressant-like effects. This reagent is valuable for studying metabolic pathways and neuronal function in various research applications.
D-Arabinose-13C-3 is a stable isotope-labeled form of D-Arabinose, an aldopentose sugar. It acts as a selective metabolic inhibitor, showing antidepressant properties and growth inhibition in C. elegans with an IC50 of 7.5 mM. D-Arabinose can penetrate the blood-brain barrier, influencing the metabolism of D-ribose and D-fructose, and exhibits antibacterial effects by inhibiting cell biofilm synthesis. Its mechanism involves activation of the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, which induces CRTC1 transcription and contributes to its antidepressant-like effects. This reagent is valuable for studying metabolic pathways and neuronal function in various research applications.
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