Dorzolamide-d5 is a deuterated form of Dorzolamide, a potent inhibitor of carbonic anhydrase II, demonstrating IC50 values of 0.18 nM for red blood cell CA-II and 600 nM for CA-I. This stable isotope variant serves as a valuable tool for tracing and analyzing metabolic pathways involving carbonic anhydrases. Additionally, Dorzolamide's anti-tumor activity makes it relevant for cancer research applications, providing insights into its molecular mechanisms.
Dorzolamide-d5 is a deuterated form of Dorzolamide, a potent inhibitor of carbonic anhydrase II, demonstrating IC50 values of 0.18 nM for red blood cell CA-II and 600 nM for CA-I. This stable isotope variant serves as a valuable tool for tracing and analyzing metabolic pathways involving carbonic anhydrases. Additionally, Dorzolamide's anti-tumor activity makes it relevant for cancer research applications, providing insights into its molecular mechanisms.
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