Exatecan-d5 mesylate is a deuterium-labeled derivative of Exatecan mesylate, functioning as a selective DNA topoisomerase I inhibitor. With an IC50 value of 2.2 μM, it effectively interferes with DNA replication and transcription processes. This reagent is valuable for cancer research, particularly in studies evaluating the mechanisms of action and resistance related to topoisomerase I-targeted therapies.
Exatecan-d5 mesylate is a deuterium-labeled derivative of Exatecan mesylate, functioning as a selective DNA topoisomerase I inhibitor. With an IC50 value of 2.2 μM, it effectively interferes with DNA replication and transcription processes. This reagent is valuable for cancer research, particularly in studies evaluating the mechanisms of action and resistance related to topoisomerase I-targeted therapies.
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