Crisaborole-d4 is a deuterium-labeled analog of Crisaborole, a selective inhibitor of phosphodiesterase 4 (PDE4). This compound exhibits potent pharmacological activity, demonstrated by its ability to inhibit PDE4 with an IC50 of 0.49 μM, leading to reduced cytokine release. Crisaborole-d4 can be utilized in biochemical research to study PDE4-related pathways and the role of cyclic AMP in inflammation and immune responses.
Crisaborole-d4 is a deuterium-labeled analog of Crisaborole, a selective inhibitor of phosphodiesterase 4 (PDE4). This compound exhibits potent pharmacological activity, demonstrated by its ability to inhibit PDE4 with an IC50 of 0.49 μM, leading to reduced cytokine release. Crisaborole-d4 can be utilized in biochemical research to study PDE4-related pathways and the role of cyclic AMP in inflammation and immune responses.
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