Roflumilast-d4 N-Oxide is a deuterium-labeled analog of Roflumilast, a selective inhibitor of phosphodiesterase 4 (PDE4). It demonstrates high potency with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while sparing the activity against PDE1, PDE2, PDE3, and PDE5 isoenzymes. This compound is valuable for pharmacokinetic studies and metabolic profiling in chemical research related to inflammatory diseases and respiratory conditions.
Roflumilast-d4 N-Oxide is a deuterium-labeled analog of Roflumilast, a selective inhibitor of phosphodiesterase 4 (PDE4). It demonstrates high potency with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while sparing the activity against PDE1, PDE2, PDE3, and PDE5 isoenzymes. This compound is valuable for pharmacokinetic studies and metabolic profiling in chemical research related to inflammatory diseases and respiratory conditions.
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