Vardenafil-d5 is a deuterium-labeled derivative of Vardenafil, a potent and selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It exhibits high selectivity for PDE5 over other phosphodiesterases, including PDE1 (180 nM) and PDE6 (11 nM). By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil-d5 effectively elevates cGMP levels. This reagent is valuable for research applications related to erectile dysfunction.
Vardenafil-d5 is a deuterium-labeled derivative of Vardenafil, a potent and selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It exhibits high selectivity for PDE5 over other phosphodiesterases, including PDE1 (180 nM) and PDE6 (11 nM). By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil-d5 effectively elevates cGMP levels. This reagent is valuable for research applications related to erectile dysfunction.
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