PLX-4720-d7 is a deuterated form of PLX-4720, a potent and selective inhibitor of B-RafV600E, exhibiting an IC50 of 13 nM in cell-free assays. This compound shows comparable potency against c-Raf-1 mutations (Y340D and Y341D) and demonstrates a tenfold selectivity for B-RafV600E over wild-type B-Raf. Its stable isotope labeling makes it suitable for advanced metabolic studies and pharmacokinetic research applications.
PLX-4720-d7 is a deuterated form of PLX-4720, a potent and selective inhibitor of B-RafV600E, exhibiting an IC50 of 13 nM in cell-free assays. This compound shows comparable potency against c-Raf-1 mutations (Y340D and Y341D) and demonstrates a tenfold selectivity for B-RafV600E over wild-type B-Raf. Its stable isotope labeling makes it suitable for advanced metabolic studies and pharmacokinetic research applications.
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