Catalog No.
Product Name
Application
Product Information
Citations
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Cholesterol Biosynthesis Inhibitor
Agistatin B is a mycotoxin derived from fungal sources that serves as a cholesterol biosynthesis inhibitor. This compound effectively disrupts the biosynthetic pathway of cholesterol, making it a valuable tool for studying lipid metabolism and related disorders. Its inhibition of cholesterol synthesis positions Agistatin B as an important reagent for research in areas such as cardiovascular disease and metabolic regulation. -
Polyketide Metabolite
Monaschromone, a polyketide metabolite, exhibits potent antifungal activity by significantly inhibiting the growth of various pathogens including Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Ganoderma saubinettii. The minimum inhibitory concentration (MIC) values for these organisms range from 6.25 to 12.5 μM. This compound is valuable for research applications focused on antifungal drug discovery and the study of plant-pathogen interactions. -
Antibiotic
Viridicatumtoxin is a potent antibiotic derived from the fungus Penicillium viridicatum, demonstrating significant antimicrobial activity. With an LD50 of 122.4 mg/kg in rat models, this mycotoxin may have potential applications in the study of bacterial resistance and the development of new antimicrobial therapies. It serves as a valuable tool for researchers investigating the pharmacological properties of novel antibiotics. -
Synthesis Dextran Inhibitor
MK-5204 is an orally active inhibitor of β-1,3-glucan synthesis, targeting the pathways involved in fungal cell wall formation. Its primary mechanism disrupts the synthesis of glucans, which are essential for fungal structural integrity. This compound serves as a valuable tool in antifungal research and development, enabling the study of fungal pathogenesis and the evaluation of novel therapeutic strategies. MK-5204 is particularly useful in elucidating the role of glucans in fungal virulence and resistance mechanisms. -
Fungal Inhibitor
Fusapyrone is a broad-spectrum antifungal metabolite that targets fungal growth by inhibiting specific pathways in various fungal species. Initially isolated from Fusarium species, it demonstrates significant efficacy against ochratoxin-producing strains of Aspergillus section Nigri, making it valuable in the control of postharvest crop diseases. Its application in agricultural research allows for the exploration of novel antifungal strategies to enhance crop quality and safety. -
Antifungal/antimitotic/anti-HIV-1 Agent
Wikstrol A is a potent antifungal, antimitotic, and anti-HIV-1 agent that primarily targets fungal and viral proliferation. This compound induces significant morphological deformation of the mycelia of P. oryzae, with a minimum effective concentration (MMDC) of 70.1 µM, and demonstrates inhibition of microtubule polymerization with an IC50 value of 131 µM. Furthermore, Wikstrol A exhibits anti-HIV-1 activity, showcasing an IC50 value of 67.8 µM, making it relevant in therapeutic research against both fungal infections and HIV-1. -
Fungal Inhibitor
Oxaziclomefone is a broad-spectrum fungicide that inhibits the growth of several plant pathogenic fungi. It exhibits significant antifungal activity, making it an effective agent in the control of various crop diseases. Oxaziclomefone is utilized in agricultural applications to safeguard crops, enhancing both yield and quality. -
Antifungal Agent
Antifungal Agent 50 is a potent antifungal compound targeting fungal cell membranes. It demonstrates minimal inhibitory concentrations (MICs) ranging from <0.063 to 1 μg/mL, indicating strong antifungal activity. This reagent is suitable for research applications involving the study of fungal infections and the development of antifungal therapies. -
Antitumor Antibiotic
Mazethramycin B is an antitumor antibiotic derived from Streptomyces thioluteus ME561-L4. It exhibits broad-spectrum antimicrobial activity, with minimum inhibitory concentrations of 1.56 μg/mL against Bacillus subtilis and 6.25 μg/mL against Candida pseudotropicalis. Mazethramycin B has shown significant efficacy in enhancing survival rates in L1210 leukemia mouse models, highlighting its potential for further research in cancer treatment and antimicrobial applications. -
Antifungal Metabolite
Eucalyptacid A is an antifungal metabolite that demonstrates significant antifungal activity against Alternaria solani, with minimum inhibitory concentration (MIC) values ranging from 6.25 to 50 μM. This compound is suitable for research applications focused on antifungal mechanisms and studying phytopathogen interactions. Its effectiveness positions it as a valuable tool for investigating potential antifungal treatments in agricultural and biomedical research. -
Antifungal Agent
Variotin is an antifungal agent that demonstrates potent antibiotic activity against dermatophytes, including Trichophyton, Microsporum, and Epidermophyton. Additionally, it is effective against pathogenic fungi associated with internal mycoses, such as Blastomyces and Cryptococcus. This compound is suitable for research applications focused on fungal infections and the mechanisms of antifungal resistance. -
Succinate Dehydrogenase Inhibitor
SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways. -
Antibiofilm Agent
β-Nor-lapachone is an antibiofilm agent that targets Candida glabrata. This compound stimulates the production of reactive oxygen species (ROS), inhibits efflux activity, and reduces both adhesion and biofilm formation, as well as the metabolism of established biofilms. Additionally, β-Nor-lapachone exhibits antifungal properties, making it a valuable tool in research aimed at combating fungal infections and biofilm-related challenges. -
Antifungal Metabolite
Chaetosemin J is an antifungal metabolite with demonstrated inhibitory activity against several plant pathogenic fungi, including Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii. Its minimum inhibitory concentration (MIC) values range from 12.5 to 25 μM, indicating its potential utility in agricultural research and studies aimed at developing new antifungal agents. -
Fungicide
SDH-IN-12 is a potent inhibitor of succinate dehydrogenase, demonstrating antifungal activity against Sclerotinia sclerotiorum and Colletotrichum arachidicola, with EC50 values of 0.97 μM and 2.07 μM, respectively. This compound is suitable for research applications aimed at understanding and controlling fungal pathogens while showing minimal herbicidal effects on both monocotyledonous and dicotyledonous plants. -
Antibiotic
Leucinostatin A is a hydrophobic nonapeptide antibiotic with significant activity against Candida albicans and Cryptococcus neoformans. This compound also demonstrates potential in inhibiting prostate cancer growth by reducing insulin-like growth factor-I expression in prostate stromal cells. Additionally, Leucinostatin A exhibits antiprotozoal properties, making it relevant for various research applications in microbiology and oncology. -
Fungal Inhibitor
2,2-Dibromopropanoic acid is a dibromo derivative of propionic acid, functioning as a potent fungal inhibitor. This compound exhibits significant mold-inhibitory properties and is widely utilized in various research applications concerning food preservation and microbial control. Its role as a chemical intermediate further enhances its utility in synthetic chemistry and biochemistry studies. -
1,3-β-glucan Synthase Inhibitor
Arborcandin A is a potent inhibitor of 1,3-β-glucan synthase, serving as an effective antifungal antibiotic. It demonstrates significant antifungal activity with IC50 values of 0.25 μg/mL against Candida albicans and 0.05 μg/mL against Aspergillus fumigatus. Arborcandin A also exhibits a minimum inhibitory concentration (MIC) of 4-8 μg/mL against various Candida species, making it a valuable tool for research in fungal pathogenesis and treatment. -
Antifungal Compound
Xanthobaccin A is an antifungal compound isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. This compound exhibits potent inhibitory effects against sugar beet damping-off disease, making it valuable for research into antifungal agents and their applications in agriculture. Its activity highlights its potential use in exploring protective measures against fungal pathogens in crop systems. -
Marine Toxin
Stellettamide A TFA is a potent marine toxin that functions as an inhibitor of calmodulin. This compound effectively inhibits various enzymes, including Ca2+/Mg2+ ATPase, phosphodiesterase, myosin light chain, and Mg2+-ATPase. It has been shown to diminish high K+- and Ca2+-induced contractions in permeabilized smooth muscle, making it a valuable tool for exploring muscle contraction mechanisms. Additionally, Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus, highlighting its potential applications in fungal infection research. -
Fungal Inhibitor
Fungicide4 is a potent fungal inhibitor targeting Phytophthora infestans. It exhibits significant activity against this strain, demonstrating its efficacy in controlling fungal outbreaks. This compound is valuable for research applications focused on plant pathology and the development of antifungal strategies. -
Chitin Synthesis Inhibitor
Cyclopent-4-ene-1,3-dione is a potent chitin synthesis inhibitor with significant antifungal activity against human pathogenic Candida species, exhibiting an IC50 in the range of 1-2 μM. Found in certain feijoa cultivars, this compound demonstrates strong antifungal bioactivity. It serves as a valuable tool for research focused on fungal infections and the mechanisms of antifungal resistance. -
Fungal Inhibitor
Chloracetophos is a potent fungal inhibitor that targets cell processes critical for fungal growth and survival. It exhibits significant antifungal activity, making it a valuable tool for research in mycology and agricultural applications. Its effectiveness in inhibiting fungal pathogens supports studies aimed at understanding fungal resistance mechanisms and developing new antifungal strategies. -
Siderophore
Nannochelin B is a citrate-hydroxamate siderophore that targets iron acquisition pathways in microbial organisms. It demonstrates significant growth-inhibitory activity against various bacterial and fungal species. This compound is useful for research applications in studying microbial iron metabolism and developing antifungal or antibacterial strategies. -
Antifungal Agent
Antifungal agent 24 is a potent antifungal compound that targets Candida albicans, exhibiting a minimum inhibitory concentration (MIC) of 0.03 μg/mL. This compound is ideal for research applications focusing on fungal infections, particularly in the context of developing therapeutic strategies against Candida species. Its high efficacy makes it a valuable tool for studying antifungal mechanisms and resistance. -
Antimicrobial Inhibitor
Antibacterial Agent 101 (Compd 7f) is an antimicrobial inhibitor targeting both bacterial and fungal pathogens. With minimum inhibitory concentration (MIC) values ranging from 4 to 32 µg/mL, it demonstrates potent antibacterial and antifungal activity. This compound is suitable for research applications focused on developing new antimicrobial therapies. -
Antifungal Metabolite
Canadensolide is an antifungal metabolite derived from Penicillium canadense. It exhibits potent antifungal activity against various pathogenic fungi, making it valuable for studying fungal infections and developing antifungal strategies. Research applications include investigating mechanisms of action in fungal resistance and exploring potential therapeutic uses in clinical settings. -
Chitin Deacetylase Inhibitor
CDA-IN-1 is a potent inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal activity. This compound effectively suppresses fungal growth by inhibiting fungal CDA activity, stimulating the plant immune response, and promoting the accumulation of reactive oxygen species (ROS). At a concentration of 100 μM, CDA-IN-1 achieves inhibition rates of 86.9% and 74.5% against the chitin deacetylases PxCDA1 and PxCDA2 of Pseudoperonospora xanthii, respectively. CDA-IN-1 is a valuable tool for research into plant fungal disease control, particularly in studies focused on diseases such as cucurbit powdery mildew and tomato gray mold. -
Antibiotic
IT-143A is an antibiotic that demonstrates significant antibacterial and antifungal activity, specifically targeting Micrococcus luteus and Aspergillus fumigatus with a minimum inhibitory concentration (MIC) ranging from 6.25 to 25 μg/mL. Additionally, IT-143A effectively inhibits the proliferation of KB cancer cells with an IC50 of 0.36 ng/mL. This compound is valuable for research applications focusing on microbial resistance and oncology studies. -
Antifungal Agent
Deoxyfusapyrone is an antifungal alpha-pyrone derived from Fusarium semitectum, targeting fungal pathogens. It exhibits significant antibacterial activity against Geotrichum candidum as demonstrated in disk diffusion assays. Additionally, Deoxyfusapyrone is non-toxic to Artemia salina larvae, making it a promising candidate for further research in antifungal applications. -
Fungal Inhibitor
Oxadixyl is a fungicide that targets fungal growth by inhibiting key cellular processes. It demonstrates significant biological activity in the presence of fungi, making it useful for evaluating its effects on microbial populations during processes such as malic fermentation in winemaking. This compound is valuable for researchers investigating antifungal treatments and their implications in fermentation science. -
Macrolide Antibiotic
PC-766B is a macrolide antibiotic that exhibits significant activity against Gram-positive bacteria, as well as certain fungi and yeasts, while showing no effectiveness against Gram-negative bacteria. Additionally, PC-766B demonstrates antitumor activity against murine tumor cells, making it a candidate for cancer research applications. It also displays weak inhibitory activity against Na+, K+-ATPase, providing insights into its potential biochemical interactions. -
Antifungal Agent
2-Decanone is an antifungal agent that targets fungal pathogenesis. It effectively inhibits mycelial growth, spore germination, and appressorium formation by downregulating key genes such as MfBmp1 and MfPls1. The compound induces the accumulation of reactive oxygen species (ROS), leading to mitochondrial damage and subsequent spore apoptosis. Its efficacy makes 2-Decanone a valuable candidate for research in postharvest disease control in fruits and vegetables. -
Fungal
Bassianin is a fungal compound recognized for its ability to inhibit erythrocyte membrane ATPase, leading to cell lysis. The compound's mechanism of action involves disrupting membrane integrity, which contributes to its biological effects. Bassianin is primarily utilized in research applications focused on investigating membrane dynamics and cellular integrity, particularly in studies related to parasitology and fungal biology. -
Anti-fungal Agent
Tylophorinicine is a phenanthroindolizidine alkaloid that acts primarily as an anti-fungal agent by inhibiting thymidylate synthase. It demonstrates minimum inhibitory concentrations (MIC) ranging from 2-4 mg/mL against TdnH and 0.6-2.5 mg/mL against TnnH for various Candida species. This compound is derived from Tylophora asthamatica and Pergularia pallida, positioning it as a valuable tool for researching antifungal mechanisms and therapeutic applications in fungal infections. -
Antibacterial Agent
PK-10 is a synergistic antibacterial agent that combines the active components of Fluconazole, exhibiting potent antifungal activity against various strains of Fluconazole-resistant Candida albicans. This compound effectively inhibits hyphae formation and induces the accumulation of reactive oxygen species, leading to mitochondrial dysfunction. Additionally, PK-10 disrupts mitochondrial membrane potential and decreases intracellular ATP levels, highlighting its potential applications in antifungal research and therapeutic development. -
Antibacterial/Antifungal Agent
Antibacterial Agent 100 (Compound 7c) is an antibacterial and antifungal reagent targeting a range of microbial pathogens. It exhibits significant biological activity with minimum inhibitory concentration (MIC) values of 4 μg/mL against Staphylococcus aureus, 4 μg/mL against Candida albicans, and 8 μg/mL against Cryptococcus neoformans. This compound is suitable for research applications focused on the inhibition of bacterial and fungal growth, making it a valuable tool in microbiological studies. -
Antifungal Agent
AS-2077715 is an antifungal agent that exhibits inhibitory activity against Trichophyton species. Isolated from the fermentation broth of Capnodium sp. 339855, this compound serves as a valuable tool for investigating fungal infections and their mechanisms. Its efficacy makes it suitable for research applications focused on antifungal drug development and the study of dermatophyte-related diseases. -
Antibiotic
Leucinostatin D is a peptide antibiotic derived from the fungus Paecilomyces marquandii. It exhibits potent antibacterial activity against Gram-positive bacteria and antifungal effects against select fungal species. This compound is valuable for studying microbial resistance mechanisms and evaluating its potential as a therapeutic agent in treating bacterial and fungal infections. -
Fungal
Antibacterial agent 67 is a potent inhibitor of succinate dehydrogenase, exhibiting an IC50 of 0.03 μM, significantly outperforming fluxapyroxad, which has an IC50 of 4.40 μM. This compound demonstrates strong antifungal activity, making it a valuable tool in research aimed at understanding fungal metabolism and developing antifungal therapies. Its high specificity and efficacy position it as a promising candidate for further study in antifungal drug discovery. -
Antifungal Limonoid
1-Deacetylnimbolinin B is a nimbolinin-type limonoid with significant antifungal activity, derived from the fruits of Melia toosendan. This compound demonstrates a broad spectrum of biological activities, including insecticidal, nematicidal, and cytotoxic effects. It is of particular interest for researchers studying natural antifungal agents and exploring the potential applications of limonoids in agricultural and medicinal contexts. -
CYP51 Inhibitor
CYP51-IN-19 is a potent inhibitor of cytochrome P450 51 (CYP51), a critical enzyme involved in sterol biosynthesis in fungi. This compound induces the generation of reactive oxygen species (ROS), leading to significant fungicidal activity. It is primarily utilized in antifungal research and the development of therapeutic agents targeting fungal infections. -
Antifungal Antibiotic
UK-2A is a potent antifungal antibiotic that targets fungal organisms through the inhibition of cell wall synthesis. Its ability to disrupt the integrity of the fungal cell wall leads to cell lysis and death, making it an effective agent in combating fungal infections. UK-2A is particularly useful in research applications focused on antifungal drug development and the mechanistic study of fungal resistance. -
Antifungal Agent
Antifungal Agent 26 is a derivative of Pradimicin A that exhibits potent antifungal, antiviral, and antiparasitic activity. Its primary mechanism involves binding to d-mannose (Man)-containing glycans present on pathogenic species. This compound serves as a valuable tool for research into fungal, viral, and parasitic infections, facilitating the study of novel therapeutic approaches in these areas. -
Fungicide
Zoxamide is an oomycete fungicide that targets the disruption of nuclear division in fungal pathogens. Its primary mechanism involves the destabilization of the microtubule cytoskeleton in Phytophthora capsici germlings, leading to impaired growth and development. Zoxamide is utilized in agricultural research to study the mechanisms of fungicide action and to develop effective management strategies against oomycete diseases. -
Fungal Inhibitor
Antifungal agent 59 is a potent fungal inhibitor with minimum inhibitory concentration (MIC) values ranging from 0.01 to 1 μg/mL. This compound effectively disrupts the formation of fungal biofilms, making it a valuable tool for research in mycology and fungal pathogenesis. Its favorable safety profile further supports its application in studying antifungal mechanisms and therapeutic approaches. -
Anti-fungal Agent
Perinaphthenone functions as an antifungal agent, exhibiting significant activity against various fungal strains. It demonstrates IC50 values of 36.2 μM and 39.0 μM against Botrytis spp. and Botryodiplodia spp. at 60 hours, respectively, as well as a notable IC50 of 13.3 μM against Fusarium spp. at day 3. This compound is primarily utilized in research applications focused on fungal inhibition and plant pathology studies. -
Fungal Inhibitor
Fludazonium chloride is a potent antifungal agent that targets a range of fungal pathogens. It exhibits strong inhibitory activity against both superficial and systemic fungal infections, making it suitable for therapeutic applications in mycoses treatment and prevention. This compound can be utilized in research to further understand antifungal mechanisms and develop new treatments. -
Antifungal Agent
Pradimicin A is a potent antifungal agent that exhibits an MIC of 4 μg/mL against Candida rugosa. In addition to its antifungal properties, Pradimicin A demonstrates antiviral activity against enveloped viruses, including coronavirus and HIV. The compound has unique aggregation properties and can selectively bind to d-mannose in the presence of calcium ions, making it a valuable tool for research in microbial pathogenesis and antiviral mechanisms. -
Echinocandin
Rezafungin is a next-generation echinocandin with a broad-spectrum antifungal activity. It exhibits potent efficacy against various fungal pathogens, including Candida spp., Aspergillus spp., and Pneumocystis spp. This compound is primarily utilized in research applications focused on antifungal resistance, therapeutic efficacy, and the development of new treatment strategies for invasive fungal infections.
