RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide that primarily targets lipopolysaccharides (LPS) on bacterial surfaces and intracellular DNA. It binds to LPS and interacts with cytoplasmic membrane phospholipids, which facilitates rapid penetration of the bacterial cell membrane. Once inside, RT2 binds to cytoplasmic components, including DNA, to exert potent antibacterial activity. This peptide shows promise for research into acute and chronic infections caused by planktonic bacteria.
RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide that primarily targets lipopolysaccharides (LPS) on bacterial surfaces and intracellular DNA. It binds to LPS and interacts with cytoplasmic membrane phospholipids, which facilitates rapid penetration of the bacterial cell membrane. Once inside, RT2 binds to cytoplasmic components, including DNA, to exert potent antibacterial activity. This peptide shows promise for research into acute and chronic infections caused by planktonic bacteria.
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