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Dermaseptin-B3

Catalog No.: A48959
Antibacterial/Antitumoral Peptide
Dermaseptin-B3 is an antibacterial and antitumoral peptide that exhibits potent activity against both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 1.3 μM for Staphylococcus aureus, 2.3 μM for Pseudomonas aeruginosa, and varying concentrations for Escherichia coli strains (ATCC 25922: 5.0 μM; 54127: 2.6 μM). Additionally, Dermaseptin-B3 demonstrates the capability to inhibit tumor cell proliferation, making it a valuable reagent for research in antimicrobial and cancer studies.
Dermaseptin-B3 210890-55-4 Antibacterial/Antitumoral Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDermaseptin-B3 is an antibacterial and antitumoral peptide that exhibits potent activity against both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 1.3 μM for Staphylococcus aureus, 2.3 μM for Pseudomonas aeruginosa, and varying concentrations for Escherichia coli strains (ATCC 25922: 5.0 μM; 54127: 2.6 μM). Additionally, Dermaseptin-B3 demonstrates the capability to inhibit tumor cell proliferation, making it a valuable reagent for research in antimicrobial and cancer studies.
Product Information
Catalog NumA48959
FormulaC127H219N35O32S
Molecular Weight2780.38
CAS Number210890-55-4
SequenceAla-Leu-Trp-Lys-Asn-Met-Leu-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Gln-Ala-Ala-Leu-Gly-Ala-Val-Lys-Thr-Leu-Val-Gly-Ala
Sequence shorteningALWKNMLKGIGKLAGQAALGAVKTLVGA
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)[C@H](C)C)=O)CC(C)C)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)C)=O)C)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(N)=O)=O)=O)C)=O)CC(C)C)=O)CCCCN)=O)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CC(C)C)=O)CCSC)=O)CC(N)=O)=O)CCCCN)=O)NC([C@@H](NC([C@H](C)N)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2
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Peptides
Microbiology > Antifection > Bacterial