Microbiology

Items 3701-3750 of 6342

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  1. Antibiotic

    A-54556A (ADEP 1) is an acyldepsipeptide antibiotic that primarily targets bacterial protein synthesis. It exhibits potent antibacterial activity against a diverse array of Gram-positive bacteria, making it a valuable tool for research on bacterial resistance and antibiotic efficacy. A-54556A is utilized in studies exploring mechanism of action and the development of novel antimicrobial agents.
  2. Antibiotic

    Carbenicillin is a semi-synthetic penicillin antibiotic that primarily targets gram-negative bacteria through the inhibition of cell wall synthesis. It exhibits broad-spectrum antibacterial activity and is characterized by its relatively low toxicity towards plant tissues. Carbenicillin is commonly utilized in microbiological research and clinical applications to study bacterial growth and resistance mechanisms.
  3. Dianionic Cephem Antibiotic

    Ceftibuten is a dianionic cephem antibiotic that exhibits potent antibacterial activity. It is effective in vitro against a variety of gram-negative bacteria and certain gram-positive pathogens. This compound is primarily used in research applications focused on antibiotic resistance and the mechanism of action of cephalosporins.
  4. Antibiotic

    Eremomycin is a potent glycopeptide antibiotic that targets bacterial cell walls to inhibit growth. It exhibits significant antibacterial activity against Staphylococcus species and Bacillus subtilis ATCC6633, with minimal inhibitory concentrations ranging from 0.03 to 1.6 μg/mL. This compound is valuable in research applications focused on antibiotic resistance and the development of new antibacterial therapies.
  5. antibiotic

    Spiramycin III is a macrolide antibiotic derived from Streptomyces ambofaciens, primarily targeting bacterial infections and Toxoplasma gondii. This compound exhibits notable antibacterial and antiparasitic activities, making it a valuable reagent for research applications focused on infectious diseases and parasitic challenges. Its versatile efficacy positions Spiramycin III as a critical tool in the study and treatment of various microbial infections.
  6. Antibacterial Agent

    Avilamycin C is an avilamycin-type antibiotic that targets bacterial cell wall synthesis. It exhibits potent antibacterial activity, particularly against Gram-positive bacteria, making it valuable in research focused on antibiotic resistance and bacterial infections. This compound serves as a crucial tool for studies investigating mechanisms of action and the development of novel antibacterial therapies.
  7. Antibiotic

    Showdomycin is an antibiotic targeting bacterial ribosomes, inhibiting protein synthesis. It is produced by Streptomyces in response to the IM-2 inducer. Showdomycin exhibits potent antibacterial activity, making it valuable for research on microbial resistance mechanisms and the development of new antibiotic therapies.
  8. Secondary Metabolite

    Aurofusarin is a secondary metabolite derived from the fungus Fusarium graminearum, known as a significant pathogen affecting vital crops in temperate regions. This compound exhibits antifungal properties and plays a role in the ecological interactions of plant-fungal systems. Aurofusarin is utilized in research to explore plant-pathogen interactions and the biosynthetic pathways of secondary metabolites.
  9. Antibiotic

    Thiocillin I is a thiopeptide antibiotic that exhibits potent antibacterial activity against Gram-positive bacteria. It has been shown to have minimum inhibitory concentration (MIC) values of 2 μg/mL against Staphylococcus aureus, 0.5 μg/mL against Enterococcus faecalis, 4 μg/mL against Bacillus subtilis, and 0.5 μg/mL against Streptococcus pyogenes. Thiocillin I is primarily used in research applications focused on bacterial resistance and antibiotic efficacy studies.
  10. Antimicrobial Agent

    11β,13-Dihydrolactucin serves as an antimicrobial agent, demonstrating significant antibacterial and antifungal properties. Additionally, this compound exhibits various biological activities, including antioxidant, anti-inflammatory, and antitumor effects. Its versatile nature makes it a valuable reagent for research applications in microbiology and cancer studies.
  11. Antibiotic

    Gilvocarcin V is an antibiotic that targets bacterial cells, exhibiting strong antibacterial activity. Isolated from Actinomycete, it also demonstrates anti-tumor properties, making it a valuable reagent for cancer research. Its dual functionality supports investigations into microbial resistance and tumor biology, contributing significantly to the understanding of these critical areas.
  12. Antibiotic

    Clovibactin is an antibiotic that effectively targets drug-resistant bacterial pathogens with no detectable resistance. This compound functions by inhibiting cell wall synthesis, specifically targeting the pyrophosphate of peptidoglycan precursors. Its unique mechanism makes Clovibactin a valuable tool for researching antibiotic resistance and developing new therapeutic strategies against challenging bacterial infections.
  13. Antibiotic

    (5S)-Neosamine C is an aminocyclic alcohol antibiotic that targets bacterial cell wall synthesis through its unique cyclized structure. This compound is derived from microbial secondary metabolites and serves as a key precursor in the biosynthesis of Neomycins. Its biological activity highlights its potential applications in antibiotic research and development.
  14. β-lactam Antibiotic

    Cefoselis is a fourth-generation cephalosporin that functions as a β-lactam antibiotic, targeting bacterial cell wall synthesis. It demonstrates potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Additionally, Cefoselis is capable of penetrating the blood-brain barrier, making it valuable for research applications related to central nervous system infections.
  15. Bacterial Inhibitor

    Bacampicillin is a penicillin antibiotic that serves as a prodrug of ampicillin, designed to enhance oral bioavailability. It exerts its antibacterial activity through the inhibition of cell wall synthesis in susceptible bacteria. This compound is utilized primarily in microbiological research and studies targeting bacterial infections.
  16. Antibiotic

    Norvancomycin hydrochloride is a glycopeptide antibiotic that targets bacterial cell wall synthesis. It demonstrates potent activity against various strains of Staphylococcus aureus and Staphylococcus epidermidis. This compound is primarily utilized in infection research to study antibiotic resistance and the mechanisms of bacterial pathogenicity.
  17. Antibiotic

    4-Aminosalicylic acid hemicalcium acts primarily as an inhibitor of dihydrofolate reductase (DHFR) and serves as an effective antituberculous agent. This compound exhibits notable anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel disease (IBD). Its oral bioavailability enhances its utility in various biochemical and pharmacological studies.
  18. Cephem Antibiotic

    Cefcapene pivoxil is a prodrug form of Cefcapene, functioning as a third-generation cephalosporin antibiotic. It exhibits a broad spectrum of antibacterial activity, making it valuable for in vitro and in vivo studies of bacterial infections. Additionally, Cefcapene pivoxil has potential applications in research related to palmoplantar pustulosis (PPP).
  19. Antibiotic

    Coformycin is a nucleoside antibiotic that primarily inhibits adenosine deaminase (ADA), an enzyme crucial for purine metabolism. This compound exhibits significant anti-tumor and anti-bacterial properties, making it valuable for research in cancer treatment and infectious disease. Coformycin's ability to modulate adenosine levels underscores its potential in therapeutic applications related to cellular proliferation and immune response.
  20. Antibiotic

    L-Amoxicillin is a broad-spectrum antibiotic primarily targeting bacterial cell wall synthesis through inhibition of penicillin-binding proteins. It is widely utilized in clinical settings, often in conjunction with the β-lactamase inhibitor potassium clavulanic acid to enhance antimicrobial efficacy. Rigorous analysis methods for L-Amoxicillin have been developed, adhering to International Conference on Harmonization (ICH) guidelines, ensuring accuracy in quality assessment. Additionally, stability studies and stress testing have been conducted to determine the compound's robustness in various formulations, reinforcing its application in infection management.
  21. Antibiotic

    Fosfomycin is a broad-spectrum antibiotic that irreversibly inhibits MurA, a crucial enzyme in bacterial cell wall synthesis. This compound effectively penetrates the blood-brain barrier and demonstrates significant antimicrobial activity against a variety of bacterial strains, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria. Fosfomycin is widely used in research for studying bacterial resistance mechanisms and developing novel therapeutic strategies.
  22. Antibiotic

    Cefoperazone dihydrate is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits a broad spectrum of antibacterial activity against various Gram-positive and Gram-negative pathogens. This compound is utilized in microbiological research and clinical settings for the treatment of infections, making it valuable for studies on antibiotic resistance and therapeutic efficacy.
  23. Antibiotic

    Pibrozelesin is a derivative of the antibiotic Duocarmycin B2, primarily targeting DNA cleavage. It demonstrates potent antitumor activity, inhibiting the proliferation of H69 cells with an IC50 of 1.9 μM. Upon activation by carboxyl esterase, Pibrozelesin induces DNA strand breaks, making it a valuable tool for cancer research and the study of DNA damage mechanisms.
  24. Beta-Lactamase Inhibitor

    β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings.
  25. Antibiotic

    Gatifloxacin sesquihydrate is a potent fluoroquinolone antibiotic that primarily targets bacterial type II topoisomerases. It exhibits broad-spectrum antibacterial activity, demonstrating significant inhibition of S. aureus topoisomerase IV and E. coli DNA gyrase with IC50 values of 13.8 μg/ml and 0.109 μg/ml, respectively. This compound is particularly useful in research related to bacterial infections and may serve as a therapeutic agent for conditions such as bacterial conjunctivitis.
  26. Antibacterial Agent

    Ticarcillin is a semisynthetic carboxypenicillin with extended-spectrum antibacterial activity, primarily targeting bacterial cell wall synthesis. It is effective against a range of gram-positive cocci, such as streptococci and staphylococci, as well as most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin is relevant for research applications involving lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections.
  27. Antibiotic

    Secnidazole hemihydrate is an orally active azole antibiotic that targets bacterial virulence through its amelioration of Serratia marcescens. This compound acts as an analog of acylhomoserine lactones, effectively inhibiting quorum sensing and reducing the pathogenesis of Pseudomonas aeruginosa. Secnidazole hemihydrate demonstrates antimicrobial activity against a range of anaerobic Gram-negative and Gram-positive bacteria in vitro. Its versatile applications in research include the study of diseases such as amoebiasis, giardiasis, and bacterial vaginitis.
  28. Antibiotic

    Teixobactin is a potent antibiotic that primarily targets cell wall synthesis in bacteria. It demonstrates significant antibacterial activity against gram-negative bacteria by binding to the conserved motifs of lipid II and lipid III. This mechanism of action makes Teixobactin a valuable reagent for research focused on bacterial resistance and the development of new antibiotic therapies.
  29. Antibiotic

    Sitafloxacin hydrochloride is a potent fluoroquinolone antibiotic that functions by inhibiting bacterial DNA gyrase and topoisomerase IV, ultimately disrupting bacterial replication. It exhibits significant antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. This compound is primarily applied in research related to respiratory and urinary tract infections.
  30. Antibiotic

    Amoxicillin arginine is an antibiotic that effectively inhibits cell wall biosynthesis by targeting polypeptide synthesis, leading to the disruption of bacterial growth. With good oral absorption and a broad spectrum of antimicrobial activity, it is utilized in various research applications related to bacterial infections and resistance mechanisms. This compound serves as an important tool for studying the pharmacological effects of β-lactam antibiotics in both clinical and laboratory settings.
  31. Antibiotic

    Zanamivir (hydrate)(5:1) is a potent inhibitor of influenza viral neuraminidase, exhibiting IC50 values of 0.95 nM for influenza A and 2.7 nM for influenza B. This compound is widely employed in antiviral research to elucidate the mechanisms of viral infection and to develop therapeutic strategies against influenza viruses. Its high inhibitory efficacy makes it a valuable tool for studying the effects of neuraminidase inhibition in both laboratory and clinical settings.
  32. Antibacterial Agent

    Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor, exhibiting an IC50 of 0.04 µM. It effectively suppresses the inflammatory response induced by Staphylococcus aureus by inhibiting the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and proteins associated with the NLRP3 inflammasome. This compound is useful for research applications focused on bacterial infections and inflammatory processes.
  33. Cephalosporin Antibiotic

    Cefotiam is a parenteral cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, making it a valuable reagent for research in microbiology and infectious disease studies. This compound is commonly used in evaluating bacterial susceptibility and understanding the mechanisms of antibiotic resistance.
  34. Antibiotic

    Netilmicin is a broad-spectrum semisynthetic aminoglycoside antibiotic targeting bacterial protein synthesis. It demonstrates significant antibacterial activity against aminoglycoside-susceptible gram-negative strains as well as aminoglycoside-resistant strains, including Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with a minimum inhibitory concentration (MIC) ranging from 0.125 to 8 μg/mL. This compound is widely used in research applications focusing on antimicrobial susceptibility and resistance mechanisms.
  35. Antibiotic

    Cefepime chloride is a broad-spectrum cephalosporin antibiotic that effectively targets both Gram-positive and Gram-negative aerobic bacteria. Its ability to penetrate the blood-brain barrier makes it a valuable agent in the treatment of central nervous system infections. Additionally, it is noted for its neurotoxic effects, making it relevant for studies investigating antimicrobial toxicity and resistance mechanisms.
  36. Antibacterial Antibiotic

    Tebipenem pivoxil hydrochloride is an orally active antibacterial agent that targets penicillin-binding proteins (PBPs) to inhibit cell wall synthesis in pathogenic bacteria. This mechanism of action makes it effective against a broad spectrum of Gram-positive and Gram-negative organisms. It is utilized in research applications focused on antibiotic resistance and the development of novel antibacterial therapies.
  37. Cephalosporin Antibiotic

    Cephalexin hydrochloride monohydrate is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. It exhibits a wide antibacterial spectrum, effective against various gram-positive and gram-negative bacteria. This compound is utilized in research related to bacterial infections, including pneumonia, strep throat, and bacterial endocarditis.
  38. Dianionic Cephem Antibiotic

    Ceftibuten monohydrate is a dianionic cephem antibiotic that exhibits potent antibacterial activity. It is effective against a broad spectrum of gram-negative bacteria and select gram-positive strains. Ceftibuten is primarily utilized in research applications focusing on antibiotic resistance and the pharmacological evaluation of cephalosporins. Its oral bioavailability makes it a valuable compound for studying systemic infection models.
  39. Antibiotic

    Sitafloxacin monohydrate is a potent fluoroquinolone antibiotic that exhibits strong antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. Its antichlamydial properties make it a valuable reagent in the study of various infections. Sitafloxacin monohydrate is particularly relevant in research focused on respiratory and urinary tract infections.
  40. Cephalosporin Antibiotic

    Cephalexin (lysine) is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. This compound exhibits broad-spectrum antibacterial activity against a range of gram-positive and gram-negative bacteria. Cephalexin (lysine) is used in research applications related to various infections, including pneumonia, streptococcal throat infections, and bacterial endocarditis.
  41. β-lactam Antibiotic

    Dicloxacillin is a β-lactam antibiotic belonging to the penicillin family, primarily targeting Gram-positive bacteria. It demonstrates effectiveness against β-lactamase-producing organisms, including Staphylococcus aureus. This compound is widely utilized in research and clinical applications to investigate bacterial resistance mechanisms and evaluate the efficacy of antibacterial treatments.
  42. Antibiotic

    A83016A is a kinamycin-type antibiotic that inhibits bacterial growth by targeting essential cellular processes. It exhibits a minimum inhibitory concentration (MIC) of 4 µg/ml against Enterococcus faecium, demonstrating its potent antibacterial activity. This compound is suitable for research applications focused on antibiotic resistance and efficacy studies in microbiology.
  43. Antibiotic

    Antibiotic SF-2132 is a peptide antibiotic derived from Nocardiopsis sp., demonstrating potent inhibitory activity against β-lactam antibiotic-resistant strains, including Pseudomonas and Escherichia. This compound is particularly valuable in research aimed at addressing antibiotic resistance and investigating novel antimicrobial mechanisms. Its efficacy against resistant pathogens makes it a crucial tool for studies in microbiology and infectious disease.
  44. Antibiotic

    Aurodox is an antibiotic derived from a variant of Streptomyces, primarily targeting gram-positive bacteria. It exhibits potent antibacterial activity while demonstrating low toxicity in murine models. Aurodox is utilized in research applications related to antibiotic efficacy and potential growth promotion in agricultural settings.
  45. Cephalosporin Antibiotic

    Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies.
  46. Antibiotic

    Anti-MRSA agent 19 is an antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA), demonstrating significant antimicrobial activity with a median MIC of 4 μg/mL. This compound effectively inhibits a diverse range of bacterial species, including those resistant to vancomycin, aminoglycosides, tetracyclines, and oxazolidinones. It serves as a valuable research tool for studying antibiotic resistance mechanisms and developing novel therapeutic strategies against resistant infections.
  47. Antibiotic

    Antibiotic TAN-592B is a potent antibiotic targeting bacterial infections. It exhibits strong antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, making it suitable for research in bacterial pathogenesis and antibiotic resistance studies. This compound can be utilized in assays to evaluate the effectiveness of antibiotic treatments and to explore novel therapeutic approaches to combat bacterial infections.
  48. Siderophore-antibiotic Conjugate

    Albomycin ε is a siderophore-antibiotic conjugate that primarily targets bacterial ribosomes, exhibiting a minimum inhibitory concentration (MIC) of >512 μg/mL. This compound demonstrates significant antibacterial activity, making it a valuable tool for research focused on Streptococcus pneumoniae and Staphylococcus aureus infections. Its unique mechanism of action offers potential insights into novel therapeutic strategies against resistant bacterial strains.
  49. Antibiotic

    2-Acetyl-2-decarboxamidotetracycline functions as an antibiotic within the tetracycline class, targeting bacterial protein synthesis by inhibiting the 30S ribosomal subunit. This compound displays a UV absorption spectrum similar to that of tetracycline and 5-oxytetracycline, particularly above 300 nm, indicative of its BCD-ring structure. Its biological activity makes it a valuable reagent in microbiological research and antibiotic development studies.
  50. Antibiotic

    KU13 is an antibiotic that acts as an inhibitor of nontuberculous mycobacteria (NTM). It demonstrates potent activity with minimum inhibitory concentrations (MIC) ranging from 0.032 to 8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. This compound is valuable for research focused on anti-infective agents and the development of treatments for mycobacterial infections.

Items 3701-3750 of 6342

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