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TP-434 (Eravacycline)

Catalog No.: A13887

TP-434 (Eravacycline)

TP-434 (Eravacycline) Chemical Structure

CAS NO. 1207283-85-9

TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$170.00
25 mg
$370.00
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  • Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
  • Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
  • Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997

Biological Activity

TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.9 mL 89.52 mL 179.03 mL
0.5 mM 3.58 mL 17.9 mL 35.81 mL
1 mM 1.79 mL 8.95 mL 17.9 mL
5 mM 0.36 mL 1.79 mL 3.58 mL

*The above data is based on the productmolecular weight 558.555. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13887
CAS No. 1207283-85-9
Formula C27H31FN4O8
M. Wt 558.555
Purity >98%
Synonyms Eravacycline, TP434, TP 434
SMILES CN(C)[[email protected]]1[[email protected]@H]2C[[email protected]@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[[email protected]@]2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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