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- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
- Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
Biological Activity
TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.9 mL | 89.52 mL | 179.03 mL |
| 0.5 mM | 3.58 mL | 17.9 mL | 35.81 mL |
| 1 mM | 1.79 mL | 8.95 mL | 17.9 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
*The above data is based on the productmolecular weight 558.555. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13887 |
|---|---|
| CAS No. | 1207283-85-9 |
| Formula | C27H31FN4O8 |
| M. Wt | 558.555 |
| Purity | >98% |
| Synonyms | Eravacycline, TP434, TP 434 |
| SMILES | CN(C)[[email protected]]1[[email protected]@H]2C[[email protected]@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[[email protected]@]2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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