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SHLP-6

Catalog No.: A31909
Mitochondrial-Derived Peptide
SHLP-6 is a mitochondrial-derived peptide that plays a significant role in regulating apoptosis. This biologically active microprotein, encoded by the MT-RNR2 gene, has been shown to enhance apoptotic processes in insulinoma NIT1 cells and human prostate cancer 22Rv1 cells. SHLP-6 is a valuable tool for investigations into the mechanisms underlying diabetes and cancer.
SHLP-6 368431-25-8 Mitochondrial-Derived Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSHLP-6 is a mitochondrial-derived peptide that plays a significant role in regulating apoptosis. This biologically active microprotein, encoded by the MT-RNR2 gene, has been shown to enhance apoptotic processes in insulinoma NIT1 cells and human prostate cancer 22Rv1 cells. SHLP-6 is a valuable tool for investigations into the mechanisms underlying diabetes and cancer.
Product Information
Catalog NumA31909
FormulaC107H177N27O30S2
Molecular Weight2385.84
CAS Number368431-25-8
SequenceMet-Leu-Asp-Gln-Asp-Ile-Pro-Met-Val-Gln-Pro-Leu-Leu-Lys-Val-Arg-Leu-Phe-Asn-Asp
Sequence shorteningMLDQDIPMVQPLLKVRLFND
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)CC(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)[C@H](CC)C)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)[C@H](C)C)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)CCC2)CCC(N)=O)=O)[C@H](C)C)=O)CCSC)=O)CCC1
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