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PTD-N5-1

Catalog No.: A35478
IRF5 Inhibitory Peptide
PTD-N5-1 is an inhibitory peptide targeting Interferon Regulatory Factor 5 (IRF5). This compound effectively blocks β-glucan-induced IL-12 production in both interferon-gamma-primed wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDCs). By suppressing IRF5-mediated IL-12 production, PTD-N5-1 plays a critical role in regulating antifungal immunity, making it valuable for research applications focused on immune response modulation.
PTD-N5-1 2088834-68-6 IRF5 Inhibitory Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPTD-N5-1 is an inhibitory peptide targeting Interferon Regulatory Factor 5 (IRF5). This compound effectively blocks β-glucan-induced IL-12 production in both interferon-gamma-primed wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDCs). By suppressing IRF5-mediated IL-12 production, PTD-N5-1 plays a critical role in regulating antifungal immunity, making it valuable for research applications focused on immune response modulation.
Product Information
Catalog NumA35478
FormulaC148H248N52O30S
Molecular Weight3267.95
CAS Number2088834-68-6
SequenceAsp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Pro-Arg-Arg-Val-Arg-Leu-Lys
Sequence shorteningDRQIKIWFQNRRMKWKKPRRVRLK
SMILESC([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)C(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC4)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCSC)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)C=5C=6C(NC5)=CC=CC6
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