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D-Arg1,D-Phe5,D-Trp7,9,Leu11-Substance P

Catalog No.: A35907
Biased Agonist for Neuropeptide/Chemokine Receptors
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a biased agonist targeting neuropeptide and chemokine receptors, specifically activating the G12 pathway. This compound binds to IL-8 and GRP receptors, resulting in the inhibition of ERK-2 activation while simultaneously promoting JNK activity. It is known to enhance neutrophil migration and calcium mobilization, contributing to its utility in inflammation research. Additionally, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acts as a bombesin antagonist and has demonstrated potential in inhibiting the growth of small cell lung cancer.
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P 96736-12-8 Biased Agonist for Neuropeptide/Chemokine Receptors
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Size Price Stock Qty
1mg
$75.00
In stock
5mg
$185.00
In stock
10mg
$280.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a biased agonist targeting neuropeptide and chemokine receptors, specifically activating the G12 pathway. This compound binds to IL-8 and GRP receptors, resulting in the inhibition of ERK-2 activation while simultaneously promoting JNK activity. It is known to enhance neutrophil migration and calcium mobilization, contributing to its utility in inflammation research. Additionally, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acts as a bombesin antagonist and has demonstrated potential in inhibiting the growth of small cell lung cancer.
Product Information
Catalog NumA35907
FormulaC79H109N19O12
Molecular Weight1516.83
CAS Number96736-12-8
Sequence{d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2
Sequence shortening{d-Arg}-PKP-{d-Phe}-Q-{d-Trp}-F-{d-Trp}-LL-NH2
SMILESC([C@H](C(N[C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)NC([C@@H](NC([C@H](NC(=O)[C@H]4N(C([C@@H](NC(=O)[C@H]5N(C([C@@H](CCCNC(=N)N)N)=O)CCC5)CCCCN)=O)CCC4)CC6=CC=CC=C6)=O)CCC(N)=O)=O)C=7C=8C(NC7)=CC=CC8
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