Coibamide A is a cytotoxic depsipeptide that exhibits potent antiproliferative activity. It induces autophagosome accumulation through an mTOR-independent pathway and triggers apoptosis in target cells. Additionally, Coibamide A effectively inhibits VEGFA/VEGFR2 expression, contributing to its ability to suppress tumor growth in glioblastoma xenograft models. This compound is valuable for research applications focused on cancer therapy and autophagy modulation.
Coibamide A is a cytotoxic depsipeptide that exhibits potent antiproliferative activity. It induces autophagosome accumulation through an mTOR-independent pathway and triggers apoptosis in target cells. Additionally, Coibamide A effectively inhibits VEGFA/VEGFR2 expression, contributing to its ability to suppress tumor growth in glioblastoma xenograft models. This compound is valuable for research applications focused on cancer therapy and autophagy modulation.
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