WLBU2 is an engineered cationic antimicrobial peptide (eCAP) that targets bacterial membranes, demonstrating rapid bactericidal activity. It exhibits minimum inhibitory concentration (MIC) values of ≤ 10 μM against a range of Gram-negative and Gram-positive bacteria, including MRSA and vancomycin-resistant enterococci. WLBU2 effectively prevents biofilm formation by Pseudomonas aeruginosa and retains antimicrobial efficacy in challenging environments such as high salinity and low pH, without compromising human airway epithelial cell viability. This reagent is valuable for research investigating cystic fibrosis and Pseudomonas aeruginosa infections.
WLBU2 is an engineered cationic antimicrobial peptide (eCAP) that targets bacterial membranes, demonstrating rapid bactericidal activity. It exhibits minimum inhibitory concentration (MIC) values of ≤ 10 μM against a range of Gram-negative and Gram-positive bacteria, including MRSA and vancomycin-resistant enterococci. WLBU2 effectively prevents biofilm formation by Pseudomonas aeruginosa and retains antimicrobial efficacy in challenging environments such as high salinity and low pH, without compromising human airway epithelial cell viability. This reagent is valuable for research investigating cystic fibrosis and Pseudomonas aeruginosa infections.
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