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(RFR)4XB

Catalog No.: A49057
Membrane-Penetrating Peptide
(RFR)4XB is a cationic membrane-penetrating peptide that facilitates the transport of therapeutic agents across the outer membrane of gram-negative bacteria. This peptide has been shown to effectively deliver antisense oligomers, enhancing their cellular uptake and bioactivity. Its unique properties make it a valuable tool for research applications focused on bacterial infection and gene regulation studies.
(RFR)4XB 1139931-15-9 Membrane-Penetrating Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(RFR)4XB is a cationic membrane-penetrating peptide that facilitates the transport of therapeutic agents across the outer membrane of gram-negative bacteria. This peptide has been shown to effectively deliver antisense oligomers, enhancing their cellular uptake and bioactivity. Its unique properties make it a valuable tool for research applications focused on bacterial infection and gene regulation studies.
Product Information
Catalog NumA49057
FormulaC93H150N38O15
Molecular Weight2040.43
CAS Number1139931-15-9
SequenceArg-Phe-Arg-Arg-Phe-Arg-Arg-Phe-Arg-Arg-Phe-Arg-{Ahx}-{βAla}
Sequence shorteningRFRRFRRFRRFR-{Ahx}-{βAla}
SMILES[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@H](CCCNC(=N)N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O
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