PA2-GNU7 is an antimicrobial peptide (AMP) that demonstrates significant antimicrobial activity, exhibiting minimal inhibitory concentrations (MIC) of 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM against Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Candida albicans, respectively. This peptide selectively targets and rapidly kills Pseudomonas aeruginosa while preserving beneficial commensal bacteria. Notably, PA2-GNU7 enhances survival rates in mice infected with Pseudomonas aeruginosa, making it a valuable candidate for the development of therapeutic interventions against multidrug-resistant infections.
PA2-GNU7 is an antimicrobial peptide (AMP) that demonstrates significant antimicrobial activity, exhibiting minimal inhibitory concentrations (MIC) of 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM against Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Candida albicans, respectively. This peptide selectively targets and rapidly kills Pseudomonas aeruginosa while preserving beneficial commensal bacteria. Notably, PA2-GNU7 enhances survival rates in mice infected with Pseudomonas aeruginosa, making it a valuable candidate for the development of therapeutic interventions against multidrug-resistant infections.
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