AKT inhibitor VIII (AKTI-1/2)

Catalog No.: A11286

AKT inhibitor

AKT inhibitor VIII (AKTI-1/2)

AKT inhibitor VIII (AKTI-1/2) Chemical Structure

CAS NO. 612847-09-3

AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$140.00
25 mg
$300.00
50 mg
$486.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Bjune K, .et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms, PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
  • Hoshiba T, .et al. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells, Biochim Biophys Acta, 2016, Nov;1863(11):2749-2757 PMID: 27558478

Biological Activity

AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
Targets
Akt1 Akt2 Akt3
58 nM210 nM2119 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.13 mL 90.65 mL 181.29 mL
0.5 mM 3.63 mL 18.13 mL 36.26 mL
1 mM 1.81 mL 9.06 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11286
Actions Inhibitor
M. Wt 551.6
Formula C34H29N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 612847-09-3
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy AKT inhibitor VIII (AKTI-1/2) | AKT inhibitor VIII (AKTI-1/2) Supplier | purchase | cost | manufacturer | order | distributor | buy 612847-09-3| 612847-09-3 Supplier | purchase 612847-09-3 | 612847-09-3 cost | 612847-09-3 manufacturer | order 612847-09-3 | 612847-09-3 distributor
Rewards