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AKT inhibitor VIII (AKTI-1/2)

AKT inhibitor VIII (AKTI-1/2)

Name: AKT inhibitor VIII (AKTI-1/2)
Brand: Adooq Bioscience
SKU: A11286
Rating: 100 (2 reviews)

Catalog No.: A11286

AKT inhibitor

Product Citations (2)

AKT inhibitor VIII (AKTI-1/2) Chemical Structure

CAS NO. 612847-09-3

AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$140.00
25 mg	$300.00
50 mg	$486.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq AKT inhibitor VIII (AKTI-1/2)

Bjune K, .et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms, PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
Hoshiba T, .et al. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells, Biochim Biophys Acta, 2016, Nov;1863(11):2749-2757 PMID: 27558478

Biological Activity

Targets

Akt1	Akt2	Akt3
58 nM	210 nM	2119 nM

Solubility *

In vitro	DMSO	19 mg/mL (34.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.13 mL	90.65 mL	181.29 mL
0.5 mM	3.63 mL	18.13 mL	36.26 mL
1 mM	1.81 mL	9.06 mL	18.13 mL
5 mM	0.36 mL	1.81 mL	3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11286
Actions	Inhibitor
CAS No.	612847-09-3
Formula	C34H29N7O
M. Wt	551.6
Solubility	DMSO
Purity	>98%
SMILES	C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.