Biological Activity
AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
Targets
Akt1 | Akt2 | Akt3 | ||
58 nM | 210 nM | 2119 nM |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.13 mL | 90.65 mL | 181.29 mL |
0.5 mM | 3.63 mL | 18.13 mL | 36.26 mL |
1 mM | 1.81 mL | 9.06 mL | 18.13 mL |
5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11286 |
---|---|
Actions | Inhibitor |
M. Wt | 551.6 |
Formula | C34H29N7O |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 612847-09-3 |
SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7 |
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