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MK-2206 2HCl

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AKT Inhibitor

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Catalog No. A10003

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MK-2206 5mg A10003-5

Regular Price: $60.00

Special Price: $54.00

MK-2206 10mg A10003-10

Regular Price: $100.00

Special Price: $90.00

MK-2206 25mg A10003-25

Regular Price: $150.00

Special Price: $135.00

MK-2206 50mg A10003-50

Regular Price: $250.00

Special Price: $225.00

MK-2206 2HCl 10mM * 1mL in DMSO A10003-10mM-D
$117.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

MK-2206 2HCl

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Publications citing Adooq Products
MK-2206 2HCl Citations (10)
  • Nishihama K,et al. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus, Metabolism, 2018, May;82:88-99 29366755
  • J Wei,et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
  • Joo Sang Lee,et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 29959327
  • Wan-Ting Hu,et al. The O-glycosylating enzyme GALNT2 suppresses the malignancy of gastric adenocarcinoma by reducing EGFR activities, Am J Cancer Res, 2018, 8(9): 1739-1751 30323967
  • Angela M. Gocher,et al. Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells, J Biol Chem, 2017, Aug 25; 292(34): 14188-14204 28634229
  • Kusuyama J,et al. Constitutive activation of p46JNK2 is indispensable for C/EBP汛 induction in the initial stage of adipogenic differentiation, Biochem J, 2017, Oct 5;474(20):3421-3437 28887384
  • Pi-Lin Sung,et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 26716408
  • Mika?l M. Martino,et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 27001940
  • Dominik Schulz,et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963-1975 27725902
  • Jewett KA,et al. The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity., J Neurochem., 2015, Oct;135(2):226-33 26250624

Chemical Information

Catalog Num A10003
Actions Inhibitor
M. Wt 480.4
Formula C25H21N5O.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032350-13-2
Synonyms MK2206
SMILES code C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl
Chemical Name 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

Biological Activity

Description
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
Targets
Akt1 (Cell-free assay) Akt2 (Cell-free assay) Akt3 (Cell-free assay)
8 nM12 nM65 nM

Solubility

Solubility (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.82 mL 104.08 mL 208.16mL
0.5 mM 4.16 mL 20.82 mL 41.63 mL
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL

*The above data is based on the productmolecular weight 480.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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