MK-2206 2HCl

Name: MK-2206 2HCl
Brand: Adooq Bioscience
SKU: A10003
Rating: 100 (10 reviews)

Catalog No.: A10003

AKT Inhibitor

Product Citations (10)

MK-2206 2HCl Chemical Structure

CAS NO. 1032350-13-2

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$72.00
25 mg	$115.00
50 mg	$162.00
10mM * 1mL in DMSO	$80.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq MK-2206 2HCl

Nishihama K, .et al. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus, Metabolism, 2018, May;82:88-99 PMID: 29366755
J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
Wan-Ting Hu, .et al. The O-glycosylating enzyme GALNT2 suppresses the malignancy of gastric adenocarcinoma by reducing EGFR activities, Am J Cancer Res, 2018, 8(9): 1739-1751 PMID: 30323967
Angela M. Gocher, .et al. Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells, J Biol Chem, 2017, Aug 25; 292(34): 14188-14204 PMID: 28634229
Kusuyama J, .et al. Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation, Biochem J, 2017, Oct 5;474(20):3421-3437 PMID: 28887384
Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408
Mikaël M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940
Dominik Schulz, .et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902
Jewett KA, .et al. The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity., J Neurochem., 2015, Oct;135(2):226-33 PMID: 26250624

Biological Activity

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

Targets

Akt1 (Cell-free assay)	Akt2 (Cell-free assay)	Akt3 (Cell-free assay)
8 nM	12 nM	65 nM

Solubility *

In vitro (25°C)	DMSO	14 mg/mL (29.14 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	15% Captisol	17 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.82 mL	104.08 mL	208.16 mL
0.5 mM	4.16 mL	20.82 mL	41.63 mL
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL

*The above data is based on the productmolecular weight 480.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10003
Actions	Inhibitor
M. Wt	480.4
Formula	C25H21N5O.2HCl
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1032350-13-2
Synonyms	MK2206
SMILES	C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl