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$0.00 - Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
Biological Activity
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.
| In vitro | DMSO | 86 mg/mL (200.5 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.32 mL | 116.58 mL | 233.15 mL |
| 0.5 mM | 4.66 mL | 23.32 mL | 46.63 mL |
| 1 mM | 2.33 mL | 11.66 mL | 23.32 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 428.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11759 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 428.9 |
| Formula | C21H25ClN6O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1143532-39-1 |
| Synonyms | AZD 5363, AZD-5363 |
| SMILES | C1CN(CCC1(C(=O)N[[email protected]@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
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