Total item
Cart Subtotal
$0.00 - Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
Biological Activity
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.
| In vitro | DMSO | 79 mg/mL (184.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.32 mL | 116.58 mL | 233.15 mL |
| 0.5 mM | 4.66 mL | 23.32 mL | 46.63 mL |
| 1 mM | 2.33 mL | 11.66 mL | 23.32 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 428.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11759 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1143532-39-1 |
| Formula | C21H25ClN6O2 |
| M. Wt | 428.9 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | AZD 5363, AZD-5363 |
| SMILES | C1CN(CCC1(C(=O)N[[email protected]@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
TIC10 isomer
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, s…
GSK2141795 (Uprosertib, GSK795)
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tum…
Deguelin
Deguelin is a natural product that displays profound antiproliferative activity.
AT7867 2HCl
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, resp…
GDC-0068 (Ipatasertib, RG-7440)
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in…
SR-13668
SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kina…
AKT inhibitor VIII (AKTI-1/2)
AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 =…
Akt1 and Akt2-IN-1
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
Keywords:buy AZD5363 | AZD5363 Supplier | purchase | cost | manufacturer | order | distributor | buy 1143532-39-1 | 1143532-39-1 Supplier | purchase 1143532-39-1 | 1143532-39-1 cost | 1143532-39-1 manufacturer | order 1143532-39-1 | 1143532-39-1 distributor
Adooq Quality Guarantee
We promise all products perform as described.