Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Giri R. Gnawali, .et al. Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors, Medicinal Chemistry Research, 2022, 31: 1154-1175
- Jeremiah J Bearss, .et al. EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics, EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867
- Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
Biological Activity
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.
In vitro | DMSO | 79 mg/mL (184.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.32 mL | 116.58 mL | 233.15 mL |
0.5 mM | 4.66 mL | 23.32 mL | 46.63 mL |
1 mM | 2.33 mL | 11.66 mL | 23.32 mL |
5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 428.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11759 |
---|---|
Actions | Inhibitor |
CAS No. | 1143532-39-1 |
Formula | C21H25ClN6O2 |
M. Wt | 428.9 |
Purity | >98% |
Synonyms | AZD 5363, AZD-5363 |
SMILES | C1CN(CCC1(C(=O)N[[email protected]@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
10-DEBC HCl
10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at …
Honokiol
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcom…
TIC10
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, s…
TIC10 isomer
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, s…
GSK2141795 (Uprosertib, GSK795)
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tum…
Deguelin
Deguelin is a natural product that displays profound antiproliferative activity.
AT7867 2HCl
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, resp…
GDC-0068 (Ipatasertib, RG-7440)
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in…
Keywords:buy AZD5363 | AZD5363 Supplier | purchase | cost | manufacturer | order | distributor | buy 1143532-39-1 | 1143532-39-1 Supplier | purchase 1143532-39-1 | 1143532-39-1 cost | 1143532-39-1 manufacturer | order 1143532-39-1 | 1143532-39-1 distributor