AZD5363

Name: AZD5363
Brand: Adooq Bioscience
SKU: A11759
Rating: 100 (3 reviews)

Catalog No.: A11759

AKT inhibitor

Product Citations (3)

AZD5363 Chemical Structure

CAS NO. 1143532-39-1

AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
25 mg	$200.00
50 mg	$300.00
10mM * 1mL in DMSO	$85.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AZD5363

Giri R. Gnawali, .et al. Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors, Medicinal Chemistry Research, 2022, 31: 1154-1175
Jeremiah J Bearss, .et al. EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics, EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867
Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

Biological Activity

AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.

Solubility *

In vitro	DMSO	79 mg/mL (184.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.32 mL	116.58 mL	233.15 mL
0.5 mM	4.66 mL	23.32 mL	46.63 mL
1 mM	2.33 mL	11.66 mL	23.32 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 428.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11759
Actions	Inhibitor
CAS No.	1143532-39-1
Formula	C21H25ClN6O2
M. Wt	428.9
Purity	>98%
Synonyms	AZD 5363, AZD-5363
SMILES	C1CN(CCC1(C(=O)N[[email protected]@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.