Fig. 1 · Structure
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Hydroxy-PEG1-C2-methyl ester
PROTAC Linkers
Hydroxy-PEG1-C2-methyl ester is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of protein degradation agents known as PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of various ligands to E3 ligase binding domains, enabling targeted degradation of specific proteins. Its application in research includes the development of innovative therapeutic strategies for cancer and other diseases by harnessing the ubiquitin-proteasome system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 93673-82-6 |
| Applications | PROTAC Linkers |
| Formula | C6H12O4 |
| Molecular Weight | 148.16 |
| Synonyms | Methyl 3-(2-hydroxyethoxy)propanoate |
| SMILES | O=C(OC)CCOCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.