p38-MAPK

Inhibitory Selectivity
Catalog No.Inhibitor Name p38 MAPKp38αp38βOther
A10824SB203580
*
PKB
A10148Doramapimod
****
A10823SB202190
**
**
A10545LY2228820
****
A10982VX-702
***
A11078PH-797804
***
*
A10983VX-745
***
*
A11582TAK-715
****
*
A11562SB239063
**
**
A12526Losmapimod
***
***
A11321Skepinone-L
****
A10895Pexmetinib
Tie-2
A10970AMG 548
****
***
A11221PD 169316
**
A11563 SD-06
*
A12408ML-3043
*
IL-1β, TNF-α
A12770Talmapimod (SCIO-469)
***
A13551Pamapimod (R-1503)
***
*
A13552RWJ 67657
*
*
A13563BMS-582949
***
A13678SB-242235
***
A16015AL 8697
****
A16035SX 011
***
A16038JX 401
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



33 Item(s)

per page

Set Descending Direction
Catalog No. Product Name Application Product Information
A13678

SB-242235

p38 MAPK inhibitor
SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
A16058

DBM 1285 dihydrochloride

p38 MAPK inhibitor
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo.
A16055

SB 706504

p38 MAPK inhibitor
SB 706504 is a p38 MAPK inhibitor, preventing LPS-induced transcription of a range of chemokineis and cytokines in chronic obstructive pulmonary disease monocyte derived macrophages.
A16038

JX 401

P38 MAPK inhibitor
JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).
A16037

EO 1428

P38 MAPK inhibitor
EO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase.
A16035

SX 011

P38 MAPK inhibitor
SX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
A16015

AL 8697

p38 MAPK inhibitor
AL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK.
A11563

SD-06

p38 MAPK inhibitor
SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).
A13552

RWJ-67657

p38 MAPK inhibitor
RWJ-67657 is a potent p38 MAPK inhibitor.
A13563

BMS-582949

p38 MAPK inhibitor
BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells.
A10895

Pexmetinib (ARRY-614)

p38 MAPK inhibitor
Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
A10970

AMG 548

p38 MAPK inhibitor
AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
A11101

SKF 86002 Dihydrochloride

p38 MAPK inhibitor
SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).
A11562 SALE

SB 239063

p38 MAPK inhibitor
SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
A11582 SALE

TAK-715

p38 MAPK inhibitor
TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
A12770

Talmapimod (SCIO-469)

p38 MAPK inhibitor
Talmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro).
A12408

ML-3043

p38 MAPK inhibitor
ML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).
A12526 SALE

Losmapimod (GW856553X)

p38 MAPK inhibitor
Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.
A13551

Pamapimod (R-1503)

p38 MAPK inhibitor
Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
A13553

Dilmapimod

p38 MAPK inhibitor
Dilmapimod is p38 MAPK inhibitor.
A16040

CMPD-1

p38 MAPK Inhibitor
CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM).
A12021 SALE

Asiaticoside

-
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
A11321 SALE

Skepinone-L

p38 MAPK inhibitor
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
A11221 SALE

PD 169316

p38 MAPK inhibitor
PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.
A10824 SALE

SB 203580

p38 MAPK inhibitor
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
A10148 SALE

Doramapimod (BIRB-796)

p38 MAPK inhibitor
Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
A10823 SALE

SB 202190

p38 MAPK Inhibitor
SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
A10545 SALE

LY2228820

p38 MAPK inhibitor
LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
A10982 SALE

VX-702

p38 MAPK inhibitor
VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
A10983 SALE

VX-745

p38 MAPK inhibitor
VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
A11078

PH-797804

p38 MAPK inhibitor
PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
A10092 SALE

Asiatic acid

Anti-inflammatory agent

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

A16236

TA-01

CK inhibitor
TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).

33 Item(s)

per page

Set Descending Direction