Trusted by 10,000+ Scientists since 2006

SB 203580


p38 MAPK inhibitor

0 Customer Reviews
Catalog No. A10824

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 203580 25mg A10824-25

Regular Price: €47.50

Special Price: €42.75

SB 203580 50mg A10824-50

Regular Price: €76.00

Special Price: €68.40

SB 203580 100mg A10824-100

Regular Price: €114.00

Special Price: €102.60

SB 203580 200mg A10824-200

Regular Price: €218.50

Special Price: €196.65

SB 203580 10mM * 1mL in DMSO A10824-10mM-D

Regular Price: €63.65

Special Price: €57.29

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

SB 203580

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products
SB 203580 Citations (4)
  • Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Uwada J, .et al. Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK, Cell Signal, 2017, Jul;35:188-196 PMID: 28412413
  • ZHIQIANG ZHANG, .et al. Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway., Mol Med Rep. , 2015, Jul;12(1):1499-505. PMID: 25815691
  • Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Chemical Information

Catalog Num A10824
Actions Inhibitor
M. Wt 377.4
Formula C21H16FN3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 152121-47-6
Synonyms SB-203580, SB203580

Biological Activity

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
p38 MAPK (THP-1 cells) PKB (THP-1 cells)
0.3 μM-0.5 μM3 μM-5 μM


Solubility (25°C)* In vitro DMSO 43 mg/mL (113.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.97mL
0.5 mM 5.3 mL 26.5 mL 52.99 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Similar product(s)

Keywords:buy SB 203580 | SB 203580 Supplier | purchase SB 203580 | SB 203580 cost | SB 203580 manufacturer | order SB 203580 | SB 203580 distributor | buy 152121-47-6| 152121-47-6 Supplier | purchase 152121-47-6 | 152121-47-6 cost | 152121-47-6 manufacturer | order 152121-47-6 | 152121-47-6 distributor