SB 203580

Catalog No.: A10824
p38 MAPK inhibitor
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
Grouped product items
Product Name Price Stock Qty
SB 203580 25mg
$50.00
In stock
SB 203580 50mg
$80.00
In stock
SB 203580 100mg
$120.00
In stock
SB 203580 200mg
$230.00
In stock
SB 203580 10mM * 1mL in DMSO
$67.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's SB 203580 has been cited by 11 publications
  • Masayuki Harada, .et al. , Cell Cycle, 2024, Feb;23(3):308-327 PMID: 38461418
  • Dan Mao, .et al. , J Oral Biosci, 2024, Mar;66(1):105-111 PMID: 38182046
  • Lei Zhang, .et al. , Stem Cell Reports, 2022, Jun 14;17(6):1428-1441 PMID: 35561683
  • Tomoyuki Hashimoto, .et al. , Ann Nucl Med, 2021, Aug 19 PMID: 34410619
  • Y Zou, .et al. , BMC Cancer, 2019, Oct 15;19(1):949 PMID: 31615459
  • Wei P, .et al. , Cell Death Dis, 2019, Sep 11;10(9):670 PMID: 31511493
  • Uwada J, .et al. , Cell Signal, 2019, Nov;63:109358 PMID: 31295519
  • Byungki Jang, .et al. , Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Uwada J, .et al. , Cell Signal, 2017, Jul;35:188-196 PMID: 28412413
  • ZHIQIANG ZHANG, .et al. , Mol Med Rep. , 2015, Jul;12(1):1499-505. PMID: 25815691
  • Choe YJ, .et al. , Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
  • Biological Activity
    Discription SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
    Targets
    Target Value
    Product Information
    Catalog Num A10824
    Formula C21H16FN3OS
    Molecular Weight 377.4
    CAS Number 152121-47-6
    SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
    Synonyms SB-203580, SB203580
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 40 mg/mL (105.97 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.5 mL 132.49 mL 264.97 mL
    0.5 mM 5.3 mL 26.5 mL 52.99 mL
    1 mM 2.65 mL 13.25 mL 26.5 mL
    5 mM 0.53 mL 2.65 mL 5.3 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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