- Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
- Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
Biological Activity
Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Targets
p38α (Cell-free assay) | p38α | |||
0.1 nM(Kd) | 38 nM |
In vitro (25°C) | DMSO | 99 mg/mL (187.61 mM) | |
Water | Insoluble | ||
Ethanol | 99 mg/mL (187.61 mM) | ||
In vivo | 5% DMSO+40%PEG300+5%Tween80??+50%H2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.95 mL | 94.75 mL | 189.5 mL |
0.5 mM | 3.79 mL | 18.95 mL | 37.9 mL |
1 mM | 1.9 mL | 9.48 mL | 18.95 mL |
5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10148 |
---|---|
Actions | Inhibitor |
CAS No. | 285983-48-4 |
Formula | C31H37N5O3 |
M. Wt | 527.7 |
Purity | >98% |
Synonyms | BIRB-796,BIRB 796 |
SMILES | CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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