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Doramapimod (BIRB-796)

Doramapimod (BIRB-796)

Name: Doramapimod (BIRB-796)
Brand: Adooq Bioscience
SKU: A10148
Rating: 100 (2 reviews)

Catalog No.: A10148

p38 MAPK inhibitor

Product Citations (2)

Doramapimod (BIRB-796) Chemical Structure

CAS NO. 285983-48-4

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Availability: In stock

Package	Price	Qty
5 mg	$30.00
10 mg	$50.00
50 mg	$135.00
100 mg	$180.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Doramapimod (BIRB-796)

Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019

Biological Activity

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Targets

p38α (Cell-free assay)	p38α
0.1 nM(Kd)	38 nM

Solubility *

In vitro (25°C)	DMSO	99 mg/mL (187.61 mM)
	Water	Insoluble
	Ethanol	99 mg/mL (187.61 mM)
In vivo	5% DMSO+40%PEG300+5%Tween80??+50%H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.95 mL	94.75 mL	189.5 mL
0.5 mM	3.79 mL	18.95 mL	37.9 mL
1 mM	1.9 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.9 mL	3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10148
Actions	Inhibitor
CAS No.	285983-48-4
Formula	C31H37N5O3
M. Wt	527.7
Purity	>98%
Synonyms	BIRB-796,BIRB 796
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.