Home /
MAPK /
p38-MAPK /
Doramapimod (BIRB-796)

Doramapimod (BIRB-796)

Name: Doramapimod (BIRB-796)
SKU: A10148

Catalog No.: A10148

p38 MAPK inhibitor

Product Citations (1)

Doramapimod (BIRB-796) Chemical Structure

CAS NO. 285983-48-4

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $30.00 Special Price $27.00
10 mg	Regular Price: $50.00 Special Price $45.00
50 mg	Regular Price: $135.00 Special Price $121.50
100 mg	Regular Price: $180.00 Special Price $162.00
10mM * 1mL in DMSO	Regular Price: $50.00 Special Price $45.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Biological Activity

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Targets

p38α (Cell-free assay)	p38α
0.1 nM(Kd)	38 nM

Solubility *

In vitro (25°C)	DMSO	106 mg/mL (200.88 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	106 mg/mL (200.88 mM)
In vivo	30% PEG400/0.5% Tween80/5% propylene glycol	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.95 mL	94.75 mL	189.5 mL
0.5 mM	3.79 mL	18.95 mL	37.9 mL
1 mM	1.9 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.9 mL	3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10148
Actions	Inhibitor
M. Wt	527.7
Formula	C31H37N5O3
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	285983-48-4
Synonyms	BIRB-796,BIRB 796
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5