Doramapimod (BIRB-796)

Catalog No.: A10148

p38 MAPK inhibitor

Doramapimod (BIRB-796)

Doramapimod (BIRB-796) Chemical Structure

CAS NO. 285983-48-4

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $30.00

Special Price $24.00

10 mg

Regular Price: $50.00

Special Price $40.00

50 mg

Regular Price: $135.00

Special Price $108.00

100 mg

Regular Price: $180.00

Special Price $144.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $40.00

Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
  • Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
  • >

Biological Activity

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Targets
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM
In vitro (25°C) DMSO 99 mg/mL (187.61 mM)
Water Insoluble
Ethanol 99 mg/mL (187.61 mM)
In vivo 5% DMSO+40%PEG300+5%Tween80??+50%H2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.75 mL 189.5 mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10148
Actions Inhibitor
CAS No. 285983-48-4
Formula C31H37N5O3
M. Wt 527.7
Purity >98%
Synonyms BIRB-796,BIRB 796
SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Doramapimod (BIRB-796) | Doramapimod (BIRB-796) Supplier | purchase | cost | manufacturer | order | distributor | buy 285983-48-4| 285983-48-4 Supplier | purchase 285983-48-4 | 285983-48-4 cost | 285983-48-4 manufacturer | order 285983-48-4 | 285983-48-4 distributor
Rewards