Doramapimod (BIRB-796)

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Grouped product items
Product Name Price Stock Qty
Doramapimod 5mg
$30.00
In stock
Doramapimod 10mg
$50.00
In stock
Doramapimod 50mg
$135.00
In stock
Doramapimod 100mg
$180.00
In stock
Doramapimod (BIRB-796) 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's Doramapimod (BIRB-796) has been cited by 3 publications
  • Ken Kobayashi, .et al. , Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
  • Junsuke Uwada, .et al. , Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
  • Perera LMB, .et al. , J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
  • Biological Activity
    Discription Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
    Targets
    Target Value
    Product Information
    Catalog Num A10148
    Formula C31H37N5O3
    Molecular Weight 527.7
    CAS Number 285983-48-4
    SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 99 mg/mL (187.61 mM)
    Water Insoluble
    Ethanol 99 mg/mL (187.61 mM)
    In vivo 5% DMSO+40%PEG300+5%Tween80??+50%H2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.95 mL 94.75 mL 189.5 mL
    0.5 mM 3.79 mL 18.95 mL 37.9 mL
    1 mM 1.9 mL 9.48 mL 18.95 mL
    5 mM 0.38 mL 1.9 mL 3.79 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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