Doramapimod (BIRB-796)

Catalog No.: A10148

p38 MAPK inhibitor

Doramapimod (BIRB-796)

Doramapimod (BIRB-796) Chemical Structure

CAS NO. 285983-48-4

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $30.00

Special Price $27.00

10 mg

Regular Price: $50.00

Special Price $45.00

50 mg

Regular Price: $135.00

Special Price $121.50

100 mg

Regular Price: $180.00

Special Price $162.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $45.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Targets
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM
In vitro (25°C) DMSO 106 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 106 mg/mL (200.88 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.75 mL 189.5 mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10148
Actions Inhibitor
M. Wt 527.7
Formula C31H37N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 285983-48-4
Synonyms BIRB-796,BIRB 796
SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

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