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$0.00 - Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
- Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215
Biological Activity
SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
Targets
| p38α (Cell-free assay) | p38β (Cell-free assay) | |||
| 50 nM | 100 nM |
| In vitro (25°C) | DMSO | 62 mg/mL (187.12 mM) | |
| Water | Insoluble | ||
| Ethanol | 11 mg/mL (33.19 mM) | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%H2O | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.18 mL | 150.92 mL | 301.84 mL |
| 0.5 mM | 6.04 mL | 30.18 mL | 60.37 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
*The above data is based on the productmolecular weight 331.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10823 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 152121-30-7 |
| Formula | C20H14N3OF |
| M. Wt | 331.3 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | SB-202190, SB202190 |
| SMILES | C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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