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SB 202190

SB 202190

Name: SB 202190
Brand: Adooq Bioscience
SKU: A10823
Rating: 100 (3 reviews)

Catalog No.: A10823

p38 MAPK Inhibitor

Product Citations (3)

SB 202190 Chemical Structure

CAS NO. 152121-30-7

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.

Availability: In stock

Package	Price	Qty
10 mg	$40.00
50 mg	$60.00
100 mg	$80.00
200 mg	$140.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq SB 202190

Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215

Biological Activity

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.

Targets

p38α (Cell-free assay)	p38β (Cell-free assay)
50 nM	100 nM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (187.12 mM)
	Water	Insoluble
	Ethanol	11 mg/mL (33.19 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%H2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.18 mL	150.92 mL	301.84 mL
0.5 mM	6.04 mL	30.18 mL	60.37 mL
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.6 mL	3.02 mL	6.04 mL

*The above data is based on the productmolecular weight 331.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10823
Actions	Inhibitor
CAS No.	152121-30-7
Formula	C20H14N3OF
M. Wt	331.3
Purity	>98%
Synonyms	SB-202190, SB202190
SMILES	C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.