SB 202190

Catalog No.: A10823

p38 MAPK Inhibitor

SB 202190

SB 202190 Chemical Structure

CAS NO. 152121-30-7

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.

Availability: In stock

Package Price Qty
10 mg
$40.00
50 mg
$60.00
100 mg
$80.00
200 mg
$140.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
  • Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
  • Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215

Biological Activity

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
Targets
p38α (Cell-free assay) p38β (Cell-free assay)
50 nM100 nM
In vitro (25°C) DMSO 66 mg/mL (199.19 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12 mg/mL (36.21 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.18 mL 150.92 mL 301.84 mL
0.5 mM 6.04 mL 30.18 mL 60.37 mL
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL

*The above data is based on the productmolecular weight 331.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10823
Actions Inhibitor
M. Wt 331.3
Formula C20H14N3OF
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 152121-30-7
Synonyms SB-202190, SB202190
SMILES C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

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