Pexmetinib (ARRY-614)

Name: Pexmetinib (ARRY-614)
Brand: Adooq Bioscience
SKU: A10895
Rating: 100 (268 reviews)

Catalog No.: A10895

p38 MAPK inhibitor

Pexmetinib (ARRY-614) Chemical Structure

CAS NO. 945614-12-0

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Availability: Out of stock

Package	Price
5 mg	$90.00
10 mg	$160.00
50 mg	$450.00
Custom Size	Get quote

Add to Wishlist

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Targets

p38 MAPK	Tie-2

Solubility *

In vitro	DMSO	96 mg/mL (172.46 mM)
	Water	Insoluble
	Ethanol	96 mg/mL (172.46 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.97 mL	89.83 mL	179.65 mL
0.5 mM	3.59 mL	17.97 mL	35.93 mL
1 mM	1.8 mL	8.98 mL	17.97 mL
5 mM	0.36 mL	1.8 mL	3.59 mL

*The above data is based on the productmolecular weight 556.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10895
Actions	Inhibitor
CAS No.	945614-12-0
Formula	C31H33FN6O3
M. Wt	556.63
Purity	>98%
Synonyms	ARRY614, ARRY 614
SMILES	O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.