Pexmetinib (ARRY-614)

Catalog No.: A10895

p38 MAPK inhibitor

Pexmetinib (ARRY-614)

Pexmetinib (ARRY-614) Chemical Structure

CAS NO. 945614-12-0

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Availability: Out of stock

Package Price
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
Targets
p38 MAPK Tie-2
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.97 mL 89.83 mL 179.65 mL
0.5 mM 3.59 mL 17.97 mL 35.93 mL
1 mM 1.8 mL 8.98 mL 17.97 mL
5 mM 0.36 mL 1.8 mL 3.59 mL

*The above data is based on the productmolecular weight 556.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10895
Actions Inhibitor
M. Wt 556.63
Formula C31H33FN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945614-12-0
Synonyms ARRY614, ARRY 614
SMILES O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5

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