Pexmetinib (ARRY-614)

Catalog No.: A10895

p38 MAPK inhibitor

Pexmetinib (ARRY-614)

Pexmetinib (ARRY-614) Chemical Structure

CAS NO. 945614-12-0

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Availability: Out of stock

Package Price
5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $160.00

Special Price $128.00

50 mg

Regular Price: $450.00

Special Price $360.00

Custom Size Get quote
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
Targets
p38 MAPK Tie-2
In vitro DMSO 96 mg/mL (172.46 mM)
Water Insoluble
Ethanol 96 mg/mL (172.46 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.97 mL 89.83 mL 179.65 mL
0.5 mM 3.59 mL 17.97 mL 35.93 mL
1 mM 1.8 mL 8.98 mL 17.97 mL
5 mM 0.36 mL 1.8 mL 3.59 mL

*The above data is based on the productmolecular weight 556.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10895
Actions Inhibitor
CAS No. 945614-12-0
Formula C31H33FN6O3
M. Wt 556.63
Purity >98%
Synonyms ARRY614, ARRY 614
SMILES O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Pexmetinib (ARRY-614) | Pexmetinib (ARRY-614) Supplier | purchase | cost | manufacturer | order | distributor | buy 945614-12-0| 945614-12-0 Supplier | purchase 945614-12-0 | 945614-12-0 cost | 945614-12-0 manufacturer | order 945614-12-0 | 945614-12-0 distributor
Rewards