Signaling Pathway
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| Discription | Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. | ||
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| Targets |
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| Catalog Num | A10895 |
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| Formula | C31H33FN6O3 |
| Molecular Weight | 556.63 |
| CAS Number | 945614-12-0 |
| SMILES | O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5 |
| Synonyms | ARRY614, ARRY 614 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 96 mg/mL (172.46 mM) | |
| Water | Insoluble | ||
| Ethanol | 96 mg/mL (172.46 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.97 mL | 89.83 mL | 179.65 mL |
| 0.5 mM | 3.59 mL | 17.97 mL | 35.93 mL |
| 1 mM | 1.8 mL | 8.98 mL | 17.97 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
