Neflamapimod (VX-745)

Name: Neflamapimod (VX-745)
SKU: A10983
Price: 50 USD
Rating: 5 (288 reviews)

Catalog No.: A10983

p38 MAPK inhibitor

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Notify me when the price drops

Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Contact your local distributors

Not your Region? View all Distributors

Adooq Products cited in reputable paper

Biological Activity

Discription

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Targets

Target	Value

Chemical Information

Catalog Num	A10983
Formula	C19H9Cl2F2N3OS
Molecular Weight	436.3
CAS Number	209410-46-8
SMILES	C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Synonyms	VX745
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	15 mg/mL (34.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.92 mL	114.6 mL	229.2 mL
0.5 mM	4.58 mL	22.92 mL	45.84 mL
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Product Name	Price	Stock
VX-745 5mg	$50.00	In stock
VX-745 10mg	$80.00	In stock
VX-745 50mg	$250.00	In stock
VX-745 100mg	$450.00	In stock
*VX-745 10mM 1mL in DMSO**	$120.00	In stock