VX-745

Name: VX-745
Brand: Adooq Bioscience
SKU: A10983
Rating: 100 (268 reviews)

Catalog No.: A10983

p38 MAPK inhibitor

VX-745 Chemical Structure

CAS NO. 209410-46-8

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$90.00
50 mg	$360.00
100 mg	$600.00
10mM * 1mL in DMSO	$120.00
Custom Size	Get quote

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Biological Activity

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Targets

p38α	p38β
10 nM	220 nM

Solubility *

In vitro (25°C)	DMSO	15 mg/mL (34.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.92 mL	114.6 mL	229.2 mL
0.5 mM	4.58 mL	22.92 mL	45.84 mL
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10983
Actions	Inhibitor
CAS No.	209410-46-8
Formula	C19H9Cl2F2N3OS
M. Wt	436.3
Purity	>98%
Synonyms	VX745
SMILES	C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.