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VX-745

Catalog No.: A10983

p38 MAPK inhibitor

VX-745

VX-745 Chemical Structure

CAS NO. 209410-46-8

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$90.00
50 mg
$360.00
100 mg
$600.00
10mM * 1mL in DMSO
$120.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
Targets
p38α p38β
10 nM220 nM
In vitro (25°C) DMSO 15 mg/mL (34.38 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.92 mL 114.6 mL 229.2 mL
0.5 mM 4.58 mL 22.92 mL 45.84 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10983
Actions Inhibitor
CAS No. 209410-46-8
Formula C19H9Cl2F2N3OS
M. Wt 436.3
Purity >98%
Synonyms VX745
SMILES C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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