Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
Targets
Target | Value |
---|---|
p38α | IC50: 7.1nM |
p38β | IC50: 0.20μM |
p38γ | IC50: >10μM |
p38δ | IC50: >10μM |
JNK1 | IC50: >10μM |
ERK1 | IC50: >10μM |
IKKβ | IC50: >10μM |
MEKK1 | IC50: >10μM |
TAK1 | IC50: >10μM |
In vitro (25°C) | DMSO | 72 mg/mL (180.22 mM) | |
Water | Insoluble | ||
Ethanol | 14 mg/mL (35.04 mM) | ||
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.03 mL | 125.15 mL | 250.31 mL |
0.5 mM | 5.01 mL | 25.03 mL | 50.06 mL |
1 mM | 2.5 mL | 12.52 mL | 25.03 mL |
5 mM | 0.5 mL | 2.5 mL | 5.01 mL |
*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11582 |
---|---|
Actions | Inhibitor |
CAS No. | 303162-79-0 |
Formula | C24H21N3OS |
M. Wt | 399.51 |
Purity | >98% |
Synonyms | TAK715, TAK 715 |
SMILES | CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
SB 202190
SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
Dilmapimod
Dilmapimod is p38 MAPK inhibitor.
PD 169316
PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.
SX 011
SX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
SB 203580
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
Pamapimod (R-1503)
Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
Asiatic acid
Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid…
SD-06
SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibi…
Keywords:buy TAK-715 | TAK-715 Supplier | purchase | cost | manufacturer | order | distributor | buy 303162-79-0| 303162-79-0 Supplier | purchase 303162-79-0 | 303162-79-0 cost | 303162-79-0 manufacturer | order 303162-79-0 | 303162-79-0 distributor