TAK-715

Name: TAK-715
Brand: Adooq Bioscience
SKU: A11582
Rating: 100 (1 reviews)

Catalog No.: A11582

p38 MAPK inhibitor

Product Citations (1)

TAK-715 Chemical Structure

CAS NO. 303162-79-0

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

Availability: In stock

Package	Price	Qty
10 mg	$110.00
25 mg	$220.00
50 mg	$320.00
100 mg	$550.00
10mM * 1mL in DMSO	$80.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq TAK-715

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Biological Activity

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

Targets

Target	Value
p38α	IC50: 7.1nM
p38β	IC50: 0.20μM
p38γ	IC50: >10μM
p38δ	IC50: >10μM
JNK1	IC50: >10μM
ERK1	IC50: >10μM
IKKβ	IC50: >10μM
MEKK1	IC50: >10μM
TAK1	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (180.22 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (35.04 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.03 mL	125.15 mL	250.31 mL
0.5 mM	5.01 mL	25.03 mL	50.06 mL
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11582
Actions	Inhibitor
CAS No.	303162-79-0
Formula	C24H21N3OS
M. Wt	399.51
Purity	>98%
Synonyms	TAK715, TAK 715
SMILES	CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.