TAK-715

TAK-715 Chemical Structure

CAS NO. 303162-79-0

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$220.00
50 mg
$320.00
100 mg
$550.00
10mM * 1mL in DMSO
$80.00
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Biological Activity

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
Targets
Target Value
p38αIC50: 7.1nM
p38βIC50: 0.20μM
p38γIC50: >10μM
p38δIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
IKKβIC50: >10μM
MEKK1IC50: >10μM
TAK1IC50: >10μM
In vitro (25°C) DMSO 80 mg/mL (200.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (40.04 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.03 mL 125.15 mL 250.31 mL
0.5 mM 5.01 mL 25.03 mL 50.06 mL
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11582
Actions Inhibitor
M. Wt 399.51
Formula C24H21N3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 303162-79-0
Synonyms TAK715, TAK 715
SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

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