Catalog No.
Product Name
Application
Product Information
Citations
-
Endogenous Metabolite
MR-16728 hydrochloride is an endogenous metabolite that primarily promotes the release of acetylcholine through inhibition of Ca(2+)-ATPase activity in presynaptic membranes. It effectively enhances acetylcholine release and demonstrates significant activity in the presence of low calcium concentrations. Research applications include studying neurotransmitter release mechanisms and analyzing acetylcholine dynamics under various physiological conditions. The compound shows a half-maximal effect at a concentration of 13.5 μM, making it a valuable tool for investigating synaptic transmission and neuromodulation. -
Endogenous Metabolite
15(R)-Prostaglandin F2α is an isomer of 9α,11β-Prostaglandin F2α, functioning as an endogenous metabolite found in urine. This compound plays a significant role in various biological processes, including the modulation of inflammation and smooth muscle contraction. It is particularly relevant for research in asthma and other respiratory conditions, making it a valuable tool for investigating underlying mechanistic pathways in these diseases. -
Fungal Metabolite
Verrucofortine is a fungal metabolite with notable alkaloid characteristics, derived from the amino acids tryptophan and leucine. This compound exhibits significant antifungal activity, making it a valuable reagent in the study of fungal infections and their treatment mechanisms. Research applications may include the analysis of fungal resistance and the development of antifungal therapeutics. -
Endogenous Metabolite
UM-2 is the 3-hydroxy metabolite of DX-8951, serving as an endogenous metabolite in humans. This compound plays a significant role in metabolic profiling and is relevant for studies investigating drug metabolism and pharmacokinetics. Researchers can utilize UM-2 to gain insights into metabolic pathways and the pharmacological impact of DX-8951. -
Endogenous Metabolite
ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation. -
Endogenous Metabolite
Pigment Red 53, an organic pigment, primarily serves as an endogenous metabolite. It exhibits excellent color stability and spectral properties, making it valuable in the coatings and plastics industries for providing a vibrant red hue. Additionally, Pigment Red 53 is utilized in the food and cosmetics sectors as a safe colorant, ensuring an appealing aesthetic for various products. Its versatility allows for applications in both industrial and consumer product development. -
Endogenous Metabolite
2-Aminopyrimidin-5-ol is an endogenous metabolite that plays a crucial role in various biological processes. It is involved in nucleotide metabolism and may influence cellular signaling pathways. Research applications include studies on metabolic profiling and the investigation of pyrimidine metabolism in health and disease contexts. -
Endogenous Metabolite
AMG-151 is a glucokinase agonist that enhances insulin secretion and lowers fasting plasma glucose (FPG) levels. In clinical evaluations, AMG-151 demonstrated a significant dose-response effect compared to placebo, indicating its potential in managing metabolic disorders. However, its use is associated with a higher incidence of hypoglycemia and hypertriglyceridemia. This compound holds promise for further research into the treatment of type 1 diabetes and related metabolic conditions. -
Endogenous Metabolite
DC_YM21 is an inhibitor of the menin-MLL interaction, demonstrating potent and selective activity in blocking cellular proliferation. This compound effectively induces cell cycle arrest and promotes differentiation in leukemia cells with MLL translocations. DC_YM21 holds significant potential for research applications targeting MLL-rearranged leukemia treatments. -
Endogenous Metabolite
Isocorydine hydrochloride is an endogenous metabolite derived from Dicranostigma leptopodum. This compound exhibits significant potential in enhancing the efficacy of Doxorubicin in the treatment of hepatocellular carcinoma (HCC). Its ability to synergistically work with chemotherapeutic agents makes it a valuable tool for cancer research and therapeutic studies targeting liver cancer. -
Endogenous Metabolite
Adefovir diphosphate is a potent antiviral agent that targets hepatitis B virus (HBV) by inhibiting reverse transcriptase, thereby blocking viral replication. This compound is also active against other viruses, including herpes viruses and HIV. In research applications, Adefovir diphosphate is utilized for its effectiveness in suppressing chronic hepatitis B and may help reduce the risk of developing hepatocellular carcinoma (HCC) in affected patients through its mechanism that involves inhibiting the autophosphorylation of growth factor receptors. -
Endogenous Metabolite
Galactonic acid is an endogenous metabolite and a sugar acid resulting from the metabolic breakdown of galactose. It is formed through the action of galactose dehydrogenase, which catalyzes the conversion of galactose to galactonolactone, subsequently leading to the formation of galactonic acid. This compound serves as a valuable research tool for studies involving carbohydrate metabolism and the biochemical pathways associated with galactose and its derivatives. -
Endogenous Metabolite
Gedocarnil is an endogenous metabolite that targets the central nervous system. It exhibits potential anxiogenic activity, making it a valuable compound for research into anxiety-related disorders. Gedocarnil can be utilized in experimental studies aimed at understanding the mechanisms underlying anxiety, although its effects may include the induction of severe anxiety attacks in clinical trial settings. -
Endogenous Metabolite
Anisperimus is an endogenous metabolite that acts as an immunosuppressant by enhancing activation-induced T cell death. It increases the sensitivity of T cells to anti-CD95 antibodies through the activation of caspase-8 and caspase-10 at the death-inducing signaling complex (DISC). Additionally, Anisperimus promotes the differentiation of Foxp3-expressing regulatory CD4 T cells, contributing to the prevention of autoimmunity within the central nervous system. This reagent is valuable for research focused on T cell regulation and autoimmune diseases. -
Fungal Metabolite
Kotanin is a fungal metabolite derived from Aspergillus glaucus, exhibiting significant bioactivity. It has been shown to possess antimicrobial properties, making it a valuable compound for research in antifungal drug development and natural product chemistry. Its unique structure and function provide insight into fungal metabolism and its potential applications in therapeutics. -
Endogenous Metabolite
LEI-101 free base is a selective and orally bioavailable agonist of the CB2 receptor, primarily targeting inflammation and oxidative stress-related conditions. It demonstrates a binding potency to CB2 receptors that is approximately 100 times greater than its affinity for CB1 receptors, with a pEC50 value of 8. The compound’s pharmacological profile suggests potential applications in the treatment of diseases such as kidney disease, making it valuable in therapeutic research. -
Endogenous Metabolite
N-Acetyl-L-arginine dihydrate is an endogenous metabolite that serves as a derivative of the amino acid arginine. It functions as a precursor for the synthesis of nitric oxide, playing a crucial role in regulating vascular tone and blood flow. This compound is widely used in biochemical studies to investigate nitric oxide signaling pathways and its implications in cardiovascular health and various physiological processes. -
Endogenous Metabolite
Rociverine is an anticholinergic agent with a primary mechanism of smooth muscle relaxation, targeting muscarinic receptors. It demonstrates diverse binding modes across five cloned muscarinic receptor types, with its cis stereoisomer exhibiting notably higher affinity than its trans counterpart. The (1R,2R) configuration of Rociverine displays affinities that can exceed 240 times higher, highlighting the significance of the (1S,2S) configuration for binding selectivity. This compound serves as a valuable tool for studying gastrointestinal motility and other smooth muscle-related conditions. -
Endogenous Metabolite
(2R,5S)-2,5-Diaminohexanoate is an endogenous metabolite involved in various biological processes. This compound serves as a building block for polyamines, which are crucial for cellular growth and function. It has applications in metabolic studies, particularly in the investigation of amino acid pathways and their roles in health and disease. Researchers utilize (2R,5S)-2,5-Diaminohexanoate to explore its potential implications in cellular metabolism and tissue homeostasis. -
Endogenous Metabolite
Glycodeoxycholic acid monohydrate is an endogenous metabolite that functions as a nuclear receptor ligand. It plays a significant role in modulating bile acid homeostasis and has implications in metabolic processes. This compound can be utilized in research studies focusing on liver function, metabolism, and signaling pathways related to nuclear receptors. -
Endogenous Metabolite
L-Xylulose is an endogenous metabolite that plays a pivotal role in various metabolic pathways. Its presence in blood, cerebrospinal fluid, and urine makes it a relevant biomarker for studying ribose-5-phosphate isomerase deficiency. This compound can aid in the investigation of metabolic disorders and provide insights into cellular functions related to carbohydrate metabolism. -
Endogenous Metabolite
Aspartylglutamate is an endogenous dipeptide that functions as an excitatory neurotransmitter by selectively binding to specific glutamate receptors. It is known to depolarize CA1 pyramidal neurons and enhance conductance in response to stimulation. This compound plays a crucial role in modulating excitatory neurotransmission in the hippocampus, particularly within the stratum radiatum, making it valuable for research in neurobiology and synaptic plasticity. -
Endogenous Metabolite
2-Methylcitric acid trisodium is an endogenous metabolite involved in the 2-methylcitric acid cycle. It serves as a significant biomarker in conditions such as methylmalonic and propionic acidemias. This compound exhibits a notable inhibitory effect on ADP-stimulated and uncoupled respiration in mitochondria when supported by glutamate, making it valuable for studies on mitochondrial function and metabolic disorders. -
Endogenous Metabolite
1-Methylhistamine is an endogenous metabolite of histamine, primarily acting as a selective ligand for the histamine H1 receptor. It plays a significant role in various physiological processes, including neurotransmission and immune response modulation. This compound is commonly used in research applications focused on studying histamine-related pathways and the effects of histamine signaling in different biological contexts. -
Endogenous Metabolite
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid that serves as an endogenous metabolite involved in various biological processes. This compound is primarily studied for its role in cell signaling, membrane dynamics, and its potential impact on inflammation and cardiovascular health. It is a valuable tool for research in lipidomics and for examining the physiological functions of phospholipids in cellular systems. -
Endogenous Metabolite
3,5-Dimethoxyphenol is an endogenous metabolite with potential implications in human health, particularly as a toxin derived from the consumption of yew leaves. This compound can serve as a useful marker for studies on plant toxicity and its metabolic pathways. Its role in biochemical research aids in understanding the effects of dietary phytochemicals on human health. -
Endogenous Metabolite
γ-Hexalactone is a gamma-lactone that serves as an endogenous metabolite. It is known to induce DNA damage and acts as a substrate for paraoxonase 1 (PON1). Its biological activity makes it useful for exploring mechanisms of cellular stress and oxidative damage in various research applications. -
Endogenous Metabolite
12-Hydroxydodecanoic acid is an endogenous metabolite known for its role in lipid metabolism. It is involved in various biological processes, including cell signaling and inflammation modulation. This compound may be applied in research related to metabolic disorders, lipidomics, and bioactive lipid studies. -
Endogenous Metabolite
MSPC is an asymmetrical phosphatidylcholine that features myristic acid (14:0) at the sn-1 position and stearic acid (18:0) at the sn-2 position. This compound exhibits the ability to self-assemble in aqueous environments, forming lipid bilayers essential for membrane biology studies. It is primarily utilized in research applications focusing on lipid membrane dynamics and structure-function relationships in cellular processes. -
Endogenous Metabolite
D-Lysine monohydrochloride is an endogenous metabolite and a stereoisomer of lysine. It plays a role in various biological processes and can serve as a building block in the synthesis of surfactants. This compound is utilized in biochemical research to study lysine-related metabolic pathways and protein interactions. -
Endogenous Metabolite
2-Hydroxymethyl benzoic acid is an endogenous metabolite involved in various biochemical pathways. It plays a role in metabolic processes and can serve as a significant biomarker in research studies examining metabolic disorders. This compound is useful for investigations in pharmacology and toxicology, providing insights into metabolic functions and potential therapeutic targets. -
Endogenous Metabolite
3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite involved in lipid metabolism. This compound is of significant interest due to its potential role as a biomarker for poor prognosis in hepatobiliary diseases. Its study can provide insights into disease progression and metabolic disturbances associated with liver conditions. -
Endogenous Metabolite
Angiotensinogen (1-14), human is a biologically active fragment of the renin substrate angiotensinogen. This endogenous metabolite serves as a natural substrate for renin and plays a critical role in the biosynthesis of all angiotensin peptides. It is widely employed in cardiovascular research and studies focused on the renin-angiotensin system, contributing to the understanding of hypertension and related disorders. -
Endogenous Metabolite
2-Amino-5-ureidopentanoic acid is an endogenous metabolite known for its role in metabolic pathways. It participates in amino acid metabolism and has potential applications in studying metabolic disorders. This compound may be useful for research involving cellular signaling and biochemical processes related to nitrogen metabolism. -
Endogenous Metabolite
Calcium stearate is a saturated fatty acid that acts as an endogenous metabolite. It is commonly found in various animal and vegetable fats and oils, playing a role in lipid metabolism. This compound is utilized in research applications involving fatty acid synthesis, energy metabolism, and the study of lipid profiles in biological systems. -
Endogenous Metabolite
4-Aminophenylphosphorylcholine is an endogenous metabolite that serves as a functional probe for biochemical applications. This compound can be conjugated to agarose gels, creating adsorbents suitable for affinity precipitation experiments. Its utility in purification processes makes it a valuable tool for investigating protein interactions and characterizing biomolecular complexes. -
Endogenous Metabolite
(S)-(-)-2-Methylbutanol is an endogenous metabolite exhibiting chirality as the S-isomer of 2-Methylbutanol. This compound is primarily involved in various metabolic pathways and plays a role in the synthesis of flavor compounds. Its biological activities make it relevant for studies on metabolic regulation and flavor chemistry in both plant and animal models. -
Endogenous Metabolite
Dimethylmalonic acid is an endogenous dicarboxylic acid that serves as a key metabolite in human serum. It is involved in various metabolic pathways and has been identified as a volatile organic compound in alveolar breath, making it noteworthy for studies on respiratory health and metabolic disorders. This compound can be utilized in research applications focused on metabolic profiling and the investigation of organic acidemias. -
Endogenous Metabolite
DL-Asparagine is a racemic mixture of L-asparagine and D-asparagine enantiomers. It serves as an endogenous metabolite and plays a crucial role in cellular metabolism and protein synthesis. DL-Asparagine is commonly utilized in microbiological growth media for the cultivation of various bacterial strains, enabling research in fields such as microbial physiology and biochemistry. -
Endogenous Metabolite
Dimethylpropiothetin hydrochloride is a hydrochloride salt of dimethylpropiothetin, an endogenous metabolite primarily found in marine algae. It serves as a precursor to dimethylsulfide (DMS) and plays a crucial role in osmoregulation in the microalga Hymenomonas carterae. This compound is valuable for research on environmental stress responses and metabolic pathways in marine ecosystems. -
Endogenous Metabolite
L-Gulose is an L-hexose sugar and a key intermediate in the biosynthesis of L-Ascorbate (vitamin C). As an endogenous metabolite, it plays a crucial role in various biochemical pathways. L-Gulose is utilized in research applications focusing on carbohydrate metabolism and vitamin C synthesis, contributing to the understanding of cellular functions and nutritional biochemistry. -
Endogenous Metabolite
Octacosanoic acid is a very long-chain saturated fatty acid that serves as an endogenous metabolite. It is primarily known for its antiplatelet and cholesterol-lowering activities, demonstrated in various animal models. This compound is relevant for studies focused on lipid metabolism and cardiovascular health, making it a valuable reagent in related biochemical research. -
Endogenous Metabolite
L-Aspartic acid disodium is an endogenous metabolite and amino acid that serves as a precursor for various biochemical processes. It is frequently utilized in the formulation of prodrugs aimed at targeting colon and cecal tissues. Additionally, L-Aspartic acid disodium plays a role in research pertaining to inflammatory conditions, aiding in the investigation of therapeutic approaches for these ailments. -
Endogenous Metabolite
2-Hydroxy-4-methylbenzaldehyde is an endogenous metabolite known for its role in various biochemical pathways. It serves as a significant biological marker and is utilized in research focusing on metabolic processes. This compound can also be instrumental in studying the metabolic profiles in cellular models and its implications in disease states. -
Endogenous Metabolite
1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite that plays a crucial role in various biological processes, including lipid metabolism and cellular signaling. This compound is primarily involved in the modulation of membrane fluidity and composition, influencing cellular functions such as signal transduction and energy storage. Its applications extend to research in metabolic diseases, cell biology, and the study of lipid-related disorders. -
Endogenous Metabolite
L-Alanyl-L-leucine is an endogenous dipeptide that plays a crucial role in various metabolic processes. It is involved in cellular signaling and may influence protein synthesis and muscle metabolism. This compound is utilized in research applications focusing on metabolism, nutrition, and potential therapeutic strategies for metabolic disorders. -
Endogenous Metabolite
(Ethoxymethyl)benzene is an endogenous metabolite that serves as an important biomarker in various biological processes. This compound may play a role in metabolic regulation and cellular signaling pathways. It can be utilized in research applications focused on metabolic profiling and the exploration of biochemical pathways related to health and disease. -
Endogenous Metabolite
H-Ser-His-OH is a short peptide known for its hydrolysis cleavage activity, acting as an endogenous metabolite within biological systems. This compound plays a role in various metabolic pathways and can be utilized in research focused on peptide biology, signaling mechanisms, and metabolic regulation. Its study may provide insights into peptide interactions and their physiological effects in organisms. -
Endogenous Metabolite
Sphingomyelins, milk are endogenous metabolites that belong to the sphingolipid class of compounds. They are crucial for various biological processes, including cell membrane structure, signaling pathways, and cellular interactions. These sphingomyelins can be utilized in research to investigate their roles in cell biology, neurobiology, and disease mechanisms associated with sphingolipid metabolism. -
Endogenous Metabolite
3-Methoxyphenylacetic acid is an endogenous metabolite derived from m-hydroxyphenylacetic acid. This compound is recognized as a phytotoxin produced by Rhizoctonia solani and plays a crucial role in investigating resistance mechanisms to rhizoctonia root rot. It is utilized in the development of toxin-mediated bioassays, facilitating research in plant pathology and resistance studies.
