Fig. 1 · Structure
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AMG-151
Cat. No.
A73367
CAS
1138669-65-4
Endogenous Metabolite
AMG-151 is a glucokinase agonist that enhances insulin secretion and lowers fasting plasma glucose (FPG) levels. In clinical evaluations, AMG-151 demonstrated a significant dose-response effect compared to placebo, indicating its potential in managing metabolic disorders. However, its use is associated with a higher incidence of hypoglycemia and hypertriglyceridemia. This compound holds promise for further research into the treatment of type 1 diabetes and related metabolic conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1138669-65-4 |
| Applications | Endogenous Metabolite |
| Formula | C20H18N6O3S2 |
| Molecular Weight | 454.53 |
| Synonyms | ARRY-403 |
| SMILES | O[C@H](CO)C1=NSC(NC2=NC=C(C=C2OC3=CC=CN=C3C)SC4=NC=CC=C4)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.