LY 190388 is a penicillamine-containing enkephalin peptide analog that acts as a μ-opioid receptor agonist. This compound demonstrates significant analgesic effects, as evidenced by its ability to inhibit the writhing response in mice following intracerebroventricular administration. Notably, the analgesic properties of LY 190388 are primarily attributed to its μ receptor activity, while co-administration with the δ receptor antagonist ICI 174864 produces an additive analgesic effect, supporting its potential applications in pain research.
LY 190388 is a penicillamine-containing enkephalin peptide analog that acts as a μ-opioid receptor agonist. This compound demonstrates significant analgesic effects, as evidenced by its ability to inhibit the writhing response in mice following intracerebroventricular administration. Notably, the analgesic properties of LY 190388 are primarily attributed to its μ receptor activity, while co-administration with the δ receptor antagonist ICI 174864 produces an additive analgesic effect, supporting its potential applications in pain research.
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