Anisperimus is an endogenous metabolite that acts as an immunosuppressant by enhancing activation-induced T cell death. It increases the sensitivity of T cells to anti-CD95 antibodies through the activation of caspase-8 and caspase-10 at the death-inducing signaling complex (DISC). Additionally, Anisperimus promotes the differentiation of Foxp3-expressing regulatory CD4 T cells, contributing to the prevention of autoimmunity within the central nervous system. This reagent is valuable for research focused on T cell regulation and autoimmune diseases.
Anisperimus is an endogenous metabolite that acts as an immunosuppressant by enhancing activation-induced T cell death. It increases the sensitivity of T cells to anti-CD95 antibodies through the activation of caspase-8 and caspase-10 at the death-inducing signaling complex (DISC). Additionally, Anisperimus promotes the differentiation of Foxp3-expressing regulatory CD4 T cells, contributing to the prevention of autoimmunity within the central nervous system. This reagent is valuable for research focused on T cell regulation and autoimmune diseases.
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