Target & Activity
| Target | Activity | Value |
|---|---|---|
| 5-LPO | IC50 | 0.6 μM |
| PLA2 | IC50 | 6.3 μM |
| FCO | IC50 | 4.2 μM |
| Cyclooxygenase |
Fig. 1 · Structure
Documents & Downloads
LY 178002
Cat. No.
A19333
CAS
107889-32-7
5-lipoxygenase inhibitor
LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 107889-32-7 |
| Applications | 5-lipoxygenase inhibitor |
| Formula | C18H25NO2S |
| Molecular Weight | 319.46 |
| SMILES | O=C1NCS/C1=C/C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.