Timegadine

Catalog No.: A17108

COX and lipo-oxygenase inhibitor

Timegadine

Timegadine Chemical Structure

CAS NO. 71079-19-1

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

Availability: In stock

Package Price Qty
1 mg
$550.00
5 mg
$1,600.00
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Biological Activity

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.36 mL 136.8 mL 273.6 mL
0.5 mM 5.47 mL 27.36 mL 54.72 mL
1 mM 2.74 mL 13.68 mL 27.36 mL
5 mM 0.55 mL 2.74 mL 5.47 mL

*The above data is based on the productmolecular weight 365.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17108
Actions Inhibitor
CAS No. 71079-19-1
Formula C20H23N5S
M. Wt 365.5
Purity >98%
Synonyms SR 1368, SR-1368, SR1368
SMILES CC1=NC2=CC=CC=C2C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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