PF-4191834

Catalog No.: A18777

5-LOX inhibitor

PF-4191834

PF-4191834 Chemical Structure

CAS NO. 1029317-21-2

PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain with an IC50=229 nM. displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes.

Availability: In stock

Package Price Qty
1 mg
$220.00
5 mg
$620.00
10 mg
$1,100.00
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Biological Activity

PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain with an IC50=229 nM. displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.41 mL 127.06 mL 254.12 mL
0.5 mM 5.08 mL 25.41 mL 50.82 mL
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18777
Actions Inhibitor
M. Wt 393.51
Formula C22H23N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1029317-21-2
Synonyms PF-04191834; PF04191834; PF 04191834; PF-4191834; PF4191834; PF 4191834.
SMILES O=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N

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